Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C25H32O2S |
| Molecular Weight | 396.585 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 1 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCS(=O)(=O)C1=CC=C(C=C1)\C=C(/C)C2=CC=C3C(=C2)C(C)(C)CCC3(C)C
InChI
InChIKey=UDAZCXVIYSIEFX-FBMGVBCBSA-N
InChI=1S/C25H32O2S/c1-7-28(26,27)21-11-8-19(9-12-21)16-18(2)20-10-13-22-23(17-20)25(5,6)15-14-24(22,3)4/h8-13,16-17H,7,14-15H2,1-6H3/b18-16+
Etarotene (Ro 15-1570) is an arotinoid sulfone. Etarotene inhibits RNase P, a ribonucleoprotein that endonucleolytically cleaves all tRNA precursors to produce the mature 5' end, thereby affecting tRNA biogenesis. Etarotene has antikeratinizing potential. It was undergoing phase III clinical trials with Roche in the US for the treatment of psoriasis and other skin.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Quantitative analysis of retinoids in biological fluids by high-performance liquid chromatography using column switching. III. Determination of the arotinoid sumarotene and its Z-isomer in human and animal plasma. | 1992 Apr 15 |
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| Regulation of the induction of ornithine decarboxylase in keratinocytes by retinoids. | 1995 Jul 1 |
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| Phorbol 12-myristate 13-acetate inhibits epidermal growth factor signalling in human keratinocytes, leading to decreased ornithine decarboxylase activity. | 1996 Oct 15 |
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| Inhibitory effects of arotinoids on tRNA biogenesis. | 2000 Nov-Dec |
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NCI_THESAURUS |
C804
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CC-39
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ACTIVE MOIETY
