FENFLUMIZOLE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C23H18F2N2O2
Molecular Weight	392.398
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC1=CC=C(C=C1)C2=C(N=C(N2)C3=CC=C(F)C=C3F)C4=CC=C(OC)C=C4

InChI

InChIKey=ITFWPRPSIAYKMV-UHFFFAOYSA-N

InChI=1S/C23H18F2N2O2/c1-28-17-8-3-14(4-9-17)21-22(15-5-10-18(29-2)11-6-15)27-23(26-21)19-12-7-16(24)13-20(19)25/h3-13H,1-2H3,(H,26,27)

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6650179 | https://www.ncbi.nlm.nih.gov/pubmed/1764333

FENFLUMIZOLE, an imidazole derivative, is a nonsteroidal, anti-inflammatory agent. It is a potent cyclooxygenase inhibitor with anti-phlogistic potency equalling that of indomethacin.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
prostaglandin-endoperoxide synthase activity 2 Target ID: GO:0004666 Sources: https://www.ncbi.nlm.nih.gov/pubmed/6417973 \| https://www.ncbi.nlm.nih.gov/pubmed/3929239	Inhibitor 8504

PubMed

Title	Date	PubMed
Peroxide chemistry of triaryl-substituted imidazoles. Fenflumizole, a non-steroidal, anti-inflammatory agent.	1991-07	1764333
Antithrombotic and ulcerogenic effects of fenflumizole, a new anti-inflammatory imidazole derivative, in rats.	1987-05	3114525
Influence of fenflumizole on platelet aggregation in man.	1984	6437841
Pharmacodynamics and toxicology of fenflumizole, a new non-steroidal anti-inflammatory imidazole derivative.	1983-10	6650179

Patents

Name

Type

Language

FENFLUMIZOL

Preferred Name

English

FENFLUMIZOLE

Common Name

English

Fenflumizole [WHO-DD]

Common Name

English

2-(2,4-DIFLUOROPHENYL)-4,5-BIS(P-METHOXYPHENYL)IMIDAZOLE

Common Name

English

fenflumizol [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C1323