U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C8H5N3O3S2
Molecular Weight 255.274
Optical Activity UNSPECIFIED
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of TENONITROZOLE

SMILES

[O-][N+](=O)C1=CN=C(NC(=O)C2=CC=CS2)S1

InChI

InChIKey=ZLOXYEZYWCTXHU-UHFFFAOYSA-N
InChI=1S/C8H5N3O3S2/c12-7(5-2-1-3-15-5)10-8-9-4-6(16-8)11(13)14/h1-4H,(H,9,10,12)

HIDE SMILES / InChI

Description

Tenonitrozole is an antiprotozoal given in the treatment of trichomoniasis. It is given orally in a dose of 250 mg twice daily with meals, for 4 days.

Originator

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
ATRICAN
PubMed

PubMed

TitleDatePubMed
[UROGENITAL SYNDROMES CAUSED BY "TRICHOMONAS VAGINALIS" AND "CANDIDA ALBICANS". RESULTS OF TREATMENT BY 2-(ALPHA-THENOYLAMINO)-5-NITROTHIAZOLE].
1963 Dec 28
[THE INFLUENCE OF ATRICAN (ALPHA-THENOYL-AMINO-2-NITRO-5-THIAZOLE) ON THE PREGNANCY AND FETAL DEVELOPMENT OF THE RAT, MOUSE AND RABBIT].
1964 May 20
Development of 5-nitrothiazole derivatives: identification of leads against both replicative and latent Mycobacterium tuberculosis.
2012 Dec 15
Patents

Sample Use Guides

In Vivo Use Guide
Urogenital trichomoniasis treatment: The usual dose is 1 capsule in the morning and 1 capsule (250 mg) in the evening during meals, for 4 days. Both partners should be treated simultaneously.
Route of Administration: Oral
In Vitro Use Guide
Tenonitrozole inhibited Giardia with IC50 value of 0.19 uM
Name Type Language
TENONITROZOLE
INN   MART.   MI   WHO-DD  
INN  
Official Name English
N-(5-NITRO-2-THIAZOLYL)-2-THIOPHENECARBOXAMIDE
Systematic Name English
TENONITROZOLE [INN]
Common Name English
TENONITROZOLE [WHO-DD]
Common Name English
TENONITROZOLE [MI]
Common Name English
TENONITROZOLE [MART.]
Common Name English
ATRICAN
Brand Name English
Classification Tree Code System Code
NCI_THESAURUS C277
Created by admin on Tue Oct 22 00:21:20 UTC 2019 , Edited by admin on Tue Oct 22 00:21:20 UTC 2019
WHO-ATC P01AX08
Created by admin on Tue Oct 22 00:21:20 UTC 2019 , Edited by admin on Tue Oct 22 00:21:20 UTC 2019
Code System Code Type Description
CAS
3810-35-3
Created by admin on Tue Oct 22 00:21:20 UTC 2019 , Edited by admin on Tue Oct 22 00:21:20 UTC 2019
PRIMARY
NCI_THESAURUS
C152561
Created by admin on Tue Oct 22 00:21:20 UTC 2019 , Edited by admin on Tue Oct 22 00:21:20 UTC 2019
PRIMARY
INN
5150
Created by admin on Tue Oct 22 00:21:20 UTC 2019 , Edited by admin on Tue Oct 22 00:21:20 UTC 2019
PRIMARY
ECHA (EC/EINECS)
223-282-9
Created by admin on Tue Oct 22 00:21:20 UTC 2019 , Edited by admin on Tue Oct 22 00:21:20 UTC 2019
PRIMARY
MERCK INDEX
M10560
Created by admin on Tue Oct 22 00:21:20 UTC 2019 , Edited by admin on Tue Oct 22 00:21:20 UTC 2019
PRIMARY Merck Index
WIKIPEDIA
TENONITROZOLE
Created by admin on Tue Oct 22 00:21:20 UTC 2019 , Edited by admin on Tue Oct 22 00:21:20 UTC 2019
PRIMARY
RXCUI
236186
Created by admin on Tue Oct 22 00:21:20 UTC 2019 , Edited by admin on Tue Oct 22 00:21:20 UTC 2019
PRIMARY RxNorm
EVMPD
SUB10897MIG
Created by admin on Tue Oct 22 00:21:20 UTC 2019 , Edited by admin on Tue Oct 22 00:21:20 UTC 2019
PRIMARY
ChEMBL
CHEMBL1082354
Created by admin on Tue Oct 22 00:21:20 UTC 2019 , Edited by admin on Tue Oct 22 00:21:20 UTC 2019
PRIMARY
PUBCHEM
19646
Created by admin on Tue Oct 22 00:21:20 UTC 2019 , Edited by admin on Tue Oct 22 00:21:20 UTC 2019
PRIMARY
EPA CompTox
3810-35-3
Created by admin on Tue Oct 22 00:21:20 UTC 2019 , Edited by admin on Tue Oct 22 00:21:20 UTC 2019
PRIMARY