MEPHENESIN CARBAMATE

US Previously Marketed

First approved in 1954

CC1=C(OCC(O)COC(N)=O)C=CC=C1

InChIKey=KRPAJLYSLFNDOA-UHFFFAOYSA-N

InChI=1S/C11H15NO4/c1-8-4-2-3-5-10(8)15-6-9(13)7-16-11(12)14/h2-5,9,13H,6-7H2,1H3,(H2,12,14)

MEPHENESIN CARBAMATE, a mephenesin derivative, is a centrally acting muscle relaxant.

Conditions

Condition	Modality	Targets	Highest Phase	Product
Muscle Spasms 1 Sources: https://books.google.ru/books?id=_J2ti4EkYpkC&pg=PA2109-IA53&lpg=PA2109-IA53&dq=Tolseram retrieved from Pharmaceutical Manufacturing Encyclopedia, 3rd Edition: William Andrew Publishing, p.2109	Primary		Approved 8429	Tolseram Approved Use Mephenesin is a centrally acting muscle relaxant. Launch Date 1954

Doses

Dose	Population	Adverse events
4 mg 1 times / day multiple, oral Dose: 4 mg, 1 times / day Route: oral Route: multiple Dose: 4 mg, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/13521594	unhealthy, 77 years n = 1 Health Status: unhealthy Condition: pain \| spasms Age Group: 77 years Sex: M Population Size: 1 Sources: https://pubmed.ncbi.nlm.nih.gov/13521594	Disc. AE: Fever, Pulmonary infiltration... AEs leading to discontinuation/dose reduction: Fever (1 patient) Pulmonary infiltration (1 patient) Eosinophilia (1 patient) Sources: https://pubmed.ncbi.nlm.nih.gov/13521594

AEs

AE	Significance	Dose	Population
Eosinophilia	1 patient Disc. AE	4 mg 1 times / day multiple, oral Dose: 4 mg, 1 times / day Route: oral Route: multiple Dose: 4 mg, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/13521594	unhealthy, 77 years n = 1 Health Status: unhealthy Condition: pain \| spasms Age Group: 77 years Sex: M Population Size: 1 Sources: https://pubmed.ncbi.nlm.nih.gov/13521594
Fever	1 patient Disc. AE	4 mg 1 times / day multiple, oral Dose: 4 mg, 1 times / day Route: oral Route: multiple Dose: 4 mg, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/13521594	unhealthy, 77 years n = 1 Health Status: unhealthy Condition: pain \| spasms Age Group: 77 years Sex: M Population Size: 1 Sources: https://pubmed.ncbi.nlm.nih.gov/13521594
Pulmonary infiltration	1 patient Disc. AE	4 mg 1 times / day multiple, oral Dose: 4 mg, 1 times / day Route: oral Route: multiple Dose: 4 mg, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/13521594	unhealthy, 77 years n = 1 Health Status: unhealthy Condition: pain \| spasms Age Group: 77 years Sex: M Population Size: 1 Sources: https://pubmed.ncbi.nlm.nih.gov/13521594

Sourcing

Vendor/Aggregator	ID	URL
ABI Chem	AC1L1VX2
Alfa Chemistry	533-06-2	https://www.alfa-chemistry.com/cas_533-06-2.htm
ChemTik	CTK4J7529
Chemhere	Achem469220
Chemieliva Pharmaceutical Co., Ltd	PBCM0623107
Chemspace	CSC010776805
Enamine	BBV-78230698
LGC Standards	LGCFOR3135.00	https://www.lgcstandards.com/US/en/p/LGCFOR3135.00
LGC Standards	MM3135.00	https://www.lgcstandards.com/US/en/p/MM3135.00
NCI Plated 2007	169508
NovoSeek	10775
THE BioTek	bt-425811	https://www.thebiotek.com/product/others/bt-425811
ZINC	ZINC000000000451	http://zinc15.docking.org/substances/ZINC000000000451
ZINC	ZINC000001678403	http://zinc15.docking.org/substances/ZINC000001678403

PubMed

Title	Date	PubMed
Mephenesin (tolserol) and mephenesin carbamate in spastic conditions.	1955 Apr	13243056
Mephenesin carbamate in the treatment of spastic paralysis.	1956 Sep 8	13371342
Clinical use of mephensin carbamate (Tolseram) in trigeminal neuralgia.	1965 Dec	5866991

Patents

Name

Type

Language

MEPHENESIN CARBAMATE

Common Name

English

MEPHENESIN CARBAMATE [MI]

Common Name

English

NSC-169508

Code

English

3-(2-METHYLPHENOXY)-1,2-PROPANEDIOL 1-CARBAMATE

Common Name

English

Code System Code Type Description

PUBCHEM

10775