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Description

Nesiritide is the recombinant form of the 32 amino acid human B-type natriuretic peptide (BNP), which is normally produced by the ventricular myocardium. Human BNP binds to the particulate guanylate cyclase receptor of vascular smooth muscle and endothelial cells, leading to increased intracellular concentrations of guanosine 3'5'-cyclic monophosphate (cGMP) and smooth muscle cell relaxation. Cyclic GMP serves as a second messenger to dilate veins and arteries. Nesiritid was sold under brand name Natrecor for the intravenous treatment of patients with acutely decompensated congestive heart failure who have dyspnea at rest or with minimal activity.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
NATRECOR
PubMed

PubMed

TitleDatePubMed
Renal subanalysis of the Acute Study of Clinical Effectiveness of Nesiritide in Decompensated Heart Failure (ASCEND-HF): the end of nesiritide as a cardiorenal therapeutic?
2014 Sep 16
Dobutamine Therapy is Associated with Worse Clinical Outcomes Compared with Nesiritide Therapy for Acute Decompensated Heart Failure: A Systematic Review and Meta-Analysis.
2015 Dec

Sample Use Guides

In Vivo Use Guide
The recommended dose of Natrecor (nesiritide) is an IV bolus of 2 µg/kg followed by a continuous infusion at a dose of 0.01 µg/kg/min. Natrecor should not be initiated at a dose that is above the recommended dose. Prime the IV tubing with an infusion of 25 mL prior to connecting to the patient's vascular access port and prior to administering the bolus or starting the infusion.
Route of Administration: Intravenous
Name Type Language
NESIRITIDE
INN   MI   USAN   VANDF   WHO-DD  
INN   USAN  
Official Name English
SER-PRO-LYS-MET-VAL-GLN-GLY-SER-GLY-CYS-PHE-GLY-ARG-LYS-MET-ASP-ARG-ILE-SER-SER-SER-SER-GLY-LEU-GLY-CYS-LYS-VAL-LEU-ARG-ARG-HIS
Common Name English
NESIRITIDE [MI]
Common Name English
NESIRITIDE [INN]
Common Name English
NESIRITIDE RECOMBINANT [VANDF]
Common Name English
NESIRITIDE RECOMBINANT [ORANGE BOOK]
Common Name English
BNP
Common Name English
NESIRITIDE [VANDF]
Common Name English
BNP-32
Common Name English
NESIRITIDE [USAN]
Common Name English
SER-PRO-LYS-MET-VAL-GLN-GLY-SER-GLY-CYS-PHE-GLY-ARG-LYS-MET-ASP-ARG-ILE-SER-SER-SER-SER-GLY-LEU-GLY-CYS-LYS-VAL-LEU-ARG-ARG-HIS CYCLIC (10->26)-DISULFIDE
Systematic Name English
NESIRITIDE RECOMBINANT
ORANGE BOOK   VANDF  
Common Name English
NESIRITIDE [WHO-DD]
Common Name English
C01DX19
Code English
BRAIN NATRIURETIC PEPTIDE 32
Common Name English
Classification Tree Code System Code
WHO-VATC QC01DX19
Created by admin on Mon Oct 21 22:12:42 UTC 2019 , Edited by admin on Mon Oct 21 22:12:42 UTC 2019
NDF-RT N0000011465
Created by admin on Mon Oct 21 22:12:42 UTC 2019 , Edited by admin on Mon Oct 21 22:12:42 UTC 2019
WHO-ATC C01DX19
Created by admin on Mon Oct 21 22:12:42 UTC 2019 , Edited by admin on Mon Oct 21 22:12:42 UTC 2019
NDF-RT N0000175593
Created by admin on Mon Oct 21 22:12:42 UTC 2019 , Edited by admin on Mon Oct 21 22:12:42 UTC 2019
NCI_THESAURUS C29707
Created by admin on Mon Oct 21 22:12:42 UTC 2019 , Edited by admin on Mon Oct 21 22:12:42 UTC 2019
Code System Code Type Description
ChEMBL
CHEMBL1201668
Created by admin on Mon Oct 21 22:12:42 UTC 2019 , Edited by admin on Mon Oct 21 22:12:42 UTC 2019
PRIMARY
NCI_THESAURUS
C47636
Created by admin on Mon Oct 21 22:12:42 UTC 2019 , Edited by admin on Mon Oct 21 22:12:42 UTC 2019
PRIMARY
LOINC
30934-4
Created by admin on Mon Oct 21 22:12:42 UTC 2019 , Edited by admin on Mon Oct 21 22:12:42 UTC 2019
PRIMARY
CAS
124584-08-3
Created by admin on Mon Oct 21 22:12:42 UTC 2019 , Edited by admin on Mon Oct 21 22:12:42 UTC 2019
PRIMARY
DRUG BANK
DB04899
Created by admin on Mon Oct 21 22:12:42 UTC 2019 , Edited by admin on Mon Oct 21 22:12:42 UTC 2019
PRIMARY
MERCK INDEX
M2635
Created by admin on Mon Oct 21 22:12:42 UTC 2019 , Edited by admin on Mon Oct 21 22:12:42 UTC 2019
PRIMARY Merck Index
EVMPD
SUB12539MIG
Created by admin on Mon Oct 21 22:12:42 UTC 2019 , Edited by admin on Mon Oct 21 22:12:42 UTC 2019
PRIMARY
INN
7790
Created by admin on Mon Oct 21 22:12:42 UTC 2019 , Edited by admin on Mon Oct 21 22:12:42 UTC 2019
PRIMARY
WIKIPEDIA
NESIRITIDE
Created by admin on Mon Oct 21 22:12:42 UTC 2019 , Edited by admin on Mon Oct 21 22:12:42 UTC 2019
PRIMARY
RXCUI
19666
Created by admin on Mon Oct 21 22:12:42 UTC 2019 , Edited by admin on Mon Oct 21 22:12:42 UTC 2019
PRIMARY RxNorm
IUPHAR
4890
Created by admin on Mon Oct 21 22:12:42 UTC 2019 , Edited by admin on Mon Oct 21 22:12:42 UTC 2019
PRIMARY