U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C27H44O2.H2O
Molecular Weight 418.6523
Optical Activity UNSPECIFIED
Defined Stereocenters 5 / 5
E/Z Centers 2
Charge 0

SHOW SMILES / InChI
Structure of CALCIFEDIOL

SMILES

O.[H][C@@]1(CC[C@@]2([H])\C(CCC[C@]12C)=C\C=C3\C[C@@H](O)CCC3=C)[C@H](C)CCCC(C)(C)O

InChI

InChIKey=WRLFSJXJGJBFJQ-WPUCQFJDSA-N
InChI=1S/C27H44O2.H2O/c1-19-10-13-23(28)18-22(19)12-11-21-9-7-17-27(5)24(14-15-25(21)27)20(2)8-6-16-26(3,4)29;/h11-12,20,23-25,28-29H,1,6-10,13-18H2,2-5H3;1H2/b21-11+,22-12-;/t20-,23+,24-,25+,27-;/m1./s1

HIDE SMILES / InChI

Description

Calcifediol (25-Hydroxyvitamin D3 or 25-hydroxycholecalciferol) is a biologically active vitamin D3 metabolite. It is concluded that the liver is the major if not the only physiologic site of hydroxylation of vitamin D3 into calcifediol. Calcifediol is a prohormone of the active form of vitamin D3, calcitriol (1,25-dihydroxyvitamin D3). Calcifediol is converted to calcitriol by cytochrome P450 27B1 (CYP27B1), also called 1-alpha hydroxylase, primarily in the kidney. Calcitriol binds to the vitamin D receptor in target tissues and activates vitamin D responsive pathways that result in increased intestinal absorption of calcium and phosphorus and reduced parathyroid hormone synthesis. RAYALDEE (calcifediol) extended-release capsules is indicated for the treatment of secondary hyperparathyroidism in adult patients with stage 3 or 4 chronic kidney disease.

CNS Activity

Originator

Approval Year

1980
57
Targets

Targets

Primary TargetPharmacologyConditionPotency
Agonist
2678
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Approved
8429
RAYALDEE

Approved Use

Calcifediol indicated for the treatment of secondary hyperparathyroidism in adults with stage 3 or 4 chronic kidney disease and serum total 25-hydroxyvitamin D levels less than 30 ng/mL

Launch Date

2016
Primary
Approved
8429
CALDEROL

Approved Use

Unknown

Launch Date

1980
Primary
Approved
8429
CALDEROL

Approved Use

Unknown

Launch Date

1980
Primary
Approved
8429
CALDEROL

Approved Use

Unknown

Launch Date

1980
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
73.2 ng/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/24516879/
20 mg 1 times / day steady-state, oral
dose: 20 mg
route of administration: Oral
experiment type: STEADY-STATE
co-administered:
CALCIFEDIOL plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE
food status: FED
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
1704.4 ng × h/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/24516879/
20 mg 1 times / day steady-state, oral
dose: 20 mg
route of administration: Oral
experiment type: STEADY-STATE
co-administered:
CALCIFEDIOL plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE
food status: FED
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
11 day
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/24516879/
20 mg 1 times / day steady-state, oral
dose: 20 mg
route of administration: Oral
experiment type: STEADY-STATE
co-administered:
CALCIFEDIOL plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE
food status: FED
Funbound

Funbound

ValueDoseCo-administeredAnalytePopulation
2%
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/24516879/
20 mg 1 times / day steady-state, oral
dose: 20 mg
route of administration: Oral
experiment type: STEADY-STATE
co-administered:
CALCIFEDIOL plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE
food status: FED
Doses

Doses

DosePopulationAdverse events​
30 ug 1 times / day multiple, oral (starting)
Dose: 30 ug, 1 times / day
Route: oral
Route: multiple
Dose: 30 ug, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/208010s000lbl.pdf
unhealthy, 66 years (range: 25-85 years)
n = 285
Health Status: unhealthy
Condition: secondary hyperparathyroidism
Age Group: 66 years (range: 25-85 years)
Sex: M+F
Population Size: 285
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/208010s000lbl.pdf
Other AEs: Anemia, Nasopharyngitis...
Other AEs:
Anemia (4.9%)
Nasopharyngitis (4.9%)
Blood creatinine increased (4.9%)
Dyspnea (4.2%)
Cough (3.5%)
Cardiac failure congestive (3.5%)
Constipation (3.2%)
Bronchitis (2.8%)
Hyperkalemia (2.5%)
Osteoarthritis (2.1%)
Hyperuricemia (1.8%)
Contusion (1.8%)
Pneumonia (1.4%)
Chronic obstructive pulmonary disease (1.4%)
Calcium increased serum (4.2%)
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/208010s000lbl.pdf
AEs

AEs

AESignificanceDosePopulation
Chronic obstructive pulmonary disease 1.4%
30 ug 1 times / day multiple, oral (starting)
Dose: 30 ug, 1 times / day
Route: oral
Route: multiple
Dose: 30 ug, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/208010s000lbl.pdf
unhealthy, 66 years (range: 25-85 years)
n = 285
Health Status: unhealthy
Condition: secondary hyperparathyroidism
Age Group: 66 years (range: 25-85 years)
Sex: M+F
Population Size: 285
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/208010s000lbl.pdf
Pneumonia 1.4%
30 ug 1 times / day multiple, oral (starting)
Dose: 30 ug, 1 times / day
Route: oral
Route: multiple
Dose: 30 ug, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/208010s000lbl.pdf
unhealthy, 66 years (range: 25-85 years)
n = 285
Health Status: unhealthy
Condition: secondary hyperparathyroidism
Age Group: 66 years (range: 25-85 years)
Sex: M+F
Population Size: 285
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/208010s000lbl.pdf
Contusion 1.8%
30 ug 1 times / day multiple, oral (starting)
Dose: 30 ug, 1 times / day
Route: oral
Route: multiple
Dose: 30 ug, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/208010s000lbl.pdf
unhealthy, 66 years (range: 25-85 years)
n = 285
Health Status: unhealthy
Condition: secondary hyperparathyroidism
Age Group: 66 years (range: 25-85 years)
Sex: M+F
Population Size: 285
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/208010s000lbl.pdf
Hyperuricemia 1.8%
30 ug 1 times / day multiple, oral (starting)
Dose: 30 ug, 1 times / day
Route: oral
Route: multiple
Dose: 30 ug, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/208010s000lbl.pdf
unhealthy, 66 years (range: 25-85 years)
n = 285
Health Status: unhealthy
Condition: secondary hyperparathyroidism
Age Group: 66 years (range: 25-85 years)
Sex: M+F
Population Size: 285
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/208010s000lbl.pdf
Osteoarthritis 2.1%
30 ug 1 times / day multiple, oral (starting)
Dose: 30 ug, 1 times / day
Route: oral
Route: multiple
Dose: 30 ug, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/208010s000lbl.pdf
unhealthy, 66 years (range: 25-85 years)
n = 285
Health Status: unhealthy
Condition: secondary hyperparathyroidism
Age Group: 66 years (range: 25-85 years)
Sex: M+F
Population Size: 285
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/208010s000lbl.pdf
Hyperkalemia 2.5%
30 ug 1 times / day multiple, oral (starting)
Dose: 30 ug, 1 times / day
Route: oral
Route: multiple
Dose: 30 ug, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/208010s000lbl.pdf
unhealthy, 66 years (range: 25-85 years)
n = 285
Health Status: unhealthy
Condition: secondary hyperparathyroidism
Age Group: 66 years (range: 25-85 years)
Sex: M+F
Population Size: 285
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/208010s000lbl.pdf
Bronchitis 2.8%
30 ug 1 times / day multiple, oral (starting)
Dose: 30 ug, 1 times / day
Route: oral
Route: multiple
Dose: 30 ug, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/208010s000lbl.pdf
unhealthy, 66 years (range: 25-85 years)
n = 285
Health Status: unhealthy
Condition: secondary hyperparathyroidism
Age Group: 66 years (range: 25-85 years)
Sex: M+F
Population Size: 285
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/208010s000lbl.pdf
Constipation 3.2%
30 ug 1 times / day multiple, oral (starting)
Dose: 30 ug, 1 times / day
Route: oral
Route: multiple
Dose: 30 ug, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/208010s000lbl.pdf
unhealthy, 66 years (range: 25-85 years)
n = 285
Health Status: unhealthy
Condition: secondary hyperparathyroidism
Age Group: 66 years (range: 25-85 years)
Sex: M+F
Population Size: 285
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/208010s000lbl.pdf
Cardiac failure congestive 3.5%
30 ug 1 times / day multiple, oral (starting)
Dose: 30 ug, 1 times / day
Route: oral
Route: multiple
Dose: 30 ug, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/208010s000lbl.pdf
unhealthy, 66 years (range: 25-85 years)
n = 285
Health Status: unhealthy
Condition: secondary hyperparathyroidism
Age Group: 66 years (range: 25-85 years)
Sex: M+F
Population Size: 285
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/208010s000lbl.pdf
Cough 3.5%
30 ug 1 times / day multiple, oral (starting)
Dose: 30 ug, 1 times / day
Route: oral
Route: multiple
Dose: 30 ug, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/208010s000lbl.pdf
unhealthy, 66 years (range: 25-85 years)
n = 285
Health Status: unhealthy
Condition: secondary hyperparathyroidism
Age Group: 66 years (range: 25-85 years)
Sex: M+F
Population Size: 285
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/208010s000lbl.pdf
Calcium increased serum 4.2%
30 ug 1 times / day multiple, oral (starting)
Dose: 30 ug, 1 times / day
Route: oral
Route: multiple
Dose: 30 ug, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/208010s000lbl.pdf
unhealthy, 66 years (range: 25-85 years)
n = 285
Health Status: unhealthy
Condition: secondary hyperparathyroidism
Age Group: 66 years (range: 25-85 years)
Sex: M+F
Population Size: 285
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/208010s000lbl.pdf
Dyspnea 4.2%
30 ug 1 times / day multiple, oral (starting)
Dose: 30 ug, 1 times / day
Route: oral
Route: multiple
Dose: 30 ug, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/208010s000lbl.pdf
unhealthy, 66 years (range: 25-85 years)
n = 285
Health Status: unhealthy
Condition: secondary hyperparathyroidism
Age Group: 66 years (range: 25-85 years)
Sex: M+F
Population Size: 285
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/208010s000lbl.pdf
Anemia 4.9%
30 ug 1 times / day multiple, oral (starting)
Dose: 30 ug, 1 times / day
Route: oral
Route: multiple
Dose: 30 ug, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/208010s000lbl.pdf
unhealthy, 66 years (range: 25-85 years)
n = 285
Health Status: unhealthy
Condition: secondary hyperparathyroidism
Age Group: 66 years (range: 25-85 years)
Sex: M+F
Population Size: 285
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/208010s000lbl.pdf
Blood creatinine increased 4.9%
30 ug 1 times / day multiple, oral (starting)
Dose: 30 ug, 1 times / day
Route: oral
Route: multiple
Dose: 30 ug, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/208010s000lbl.pdf
unhealthy, 66 years (range: 25-85 years)
n = 285
Health Status: unhealthy
Condition: secondary hyperparathyroidism
Age Group: 66 years (range: 25-85 years)
Sex: M+F
Population Size: 285
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/208010s000lbl.pdf
Nasopharyngitis 4.9%
30 ug 1 times / day multiple, oral (starting)
Dose: 30 ug, 1 times / day
Route: oral
Route: multiple
Dose: 30 ug, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/208010s000lbl.pdf
unhealthy, 66 years (range: 25-85 years)
n = 285
Health Status: unhealthy
Condition: secondary hyperparathyroidism
Age Group: 66 years (range: 25-85 years)
Sex: M+F
Population Size: 285
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/208010s000lbl.pdf
Overview

Overview

CYP3A4CYP2C9CYP2D6hERG

OverviewOther

Other InhibitorOther SubstrateOther Inducer
CYP27B1
3

UGT enzymes
27
Drug as victim

Drug as victim

TargetModalityActivityMetaboliteClinical evidence
UGT enzymes
27
 likely
CYP27B1
3
 yes
Sourcing

Sourcing

Vendor/AggregatorIDURL
AHH Chemical co.,ltd
MT-48884
http://www.ahhchemical.com/product/MT-48884.html
Achemtek
0102-017034
http://www.achemtek.com/19356-17-3
ApexBio Technology
B2140
http://www.apexbt.com/calcifediol-26843.html
ApexBio Technology
B1056
http://www.apexbt.com/calcifediol-d6.html
Aurora Fine Chemicals LLC
A17.876.862
http://online.aurorafinechemicals.com/info?ID=A17.876.862
Aurum Pharmatech LLC
W-5159
http://www.Aurumpharmatech.com/Product/ProductDetails/W_5159
AvaChem Scientific
2558
http://www.avachem.com/productSearch.asp?2558
BioCrick
BCC4949
http://www.biocrick.com/Calcifediol-BCC4949.html
BioSynth
W-201718
https://www.biosynth.com/en/products/life-science/other-biochemicals/products/W-201718.html
Boerchem
BC219279
http://www.boerchem.com/?product_36973.html
Capot Chemical
18824
http://www.capotchem.com/en/18824.htm
Capot Chemical
PubChem18824
http://www.capotchem.com/en/18824.htm
Chem Scene
CS-0800
http://www.chemscene.com/19356-17-3.html
ChemFaces
CFN94017
http://www.chemfaces.com/natural/25-Hydroxycholecalciferol-monohydrate-CFN94017.html
ChemMol
44005951
http://www.chemmol.com/chemmol/44005951.html
Chemspace
CSSB00032005042
https://chem-space.com/CSSB00032005042
Chiralblock Biosciences
CB11410
http://www.chiralblock.com/products/63283-36-3.html
EMD Biosciences
679102
http://www.emdbiosciences.com/product/679102
EMD Millipore
679102
http://www.emdbiosciences.com/product/679102
Glentham Life Sciences
GV7732
http://www.glentham.com/products/product/GV7732/
Lab Network
LN00197433
https://labnetwork.com/frontend-app/p/#!/moleculedetails/LN00197433
MedChem Express
HY-32351
https://www.medchemexpress.com/Calcifediol.html
MuseChem
R028208
https://www.musechem.com/product/R028208.html
OChem
8414
http://www.ocheminc.com/index.php?act=psearch&pid=356C173
Parchem
28428
http://www.parchem.com/chemical-supplier-distributor/Calcifediol-018428.aspx
Selleck Chemicals
S1469
http://www.selleckchem.com/products/Calcifediol.html
Sigma-Aldrich
739642_ALDRICH
https://www.sigmaaldrich.com/catalog/product/aldrich/739642?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich
739650_ALDRICH
https://www.sigmaaldrich.com/catalog/product/aldrich/739650?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich
739669_ALDRICH
https://www.sigmaaldrich.com/catalog/product/aldrich/739669?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich
17938_SIGMA
https://www.sigmaaldrich.com/catalog/product/sigma/17938?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich
1086108_USP
https://www.sigmaaldrich.com/catalog/product/usp/1086108?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Tocris
4036
https://www.tocris.com/products/calcifediol_4036
VladaChem
VL273145-10MG
https://www.vladachem.com/product.php?products=19356-17-3
Yuhao Chemical
XJ4467
http://www.chemyuhao.com/19356-17-3.html
abcr GmbH
AB503647
http://www.abcr.com/shop/en/AB503647
abcr GmbH
AB443287
http://www.abcr.de/shop/en/AB443287
eNovation Chemicals
D699759
https://www.enovationchem.com/ProductDetails.asp?ProductID=D699759
eNovation Chemicals
D763693
https://www.enovationchem.com/ProductDetails.asp?ProductID=D763693
eNovation Chemicals
Y0974281
https://www.enovationchem.com/ProductDetails.asp?ProductID=Y0974281
iChemical
EBD2201904
http://www.ichemical.com/products/19356-17-3.html?utm_source=PubChem&utm_medium=website&utm_campaign=product%20catalogs
PubMed

PubMed

TitleDatePubMed
Determination of vitamin D and its metabolites in plasma from normal and anephric man.
1979 Jul 15
Interrelationship of serum 25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D in juvenile renal osteodystrophy after therapy with 25-hydroxyvitamin D3.
1982
Tubular aggregates in a case of osteomalacic myopathy due to anticonvulsant drugs.
1984 Jan-Feb
Hypercalcemia in 25 OH D3 treated patients receiving a calcium exchange resin.
1985 Jun
The effect of vitamin D status on cutaneous sterologenesis in vivo and in vitro.
1987 Sep 14
Inhibition of tubercle bacilli in cultured human macrophages by chloroquine used alone and in combination with streptomycin, isoniazid, pyrazinamide, and two metabolites of vitamin D3.
1990 Nov
Vitamin D3 compounds regulate human immunodeficiency virus type 1 replication in U937 monoblastoid cells and in monocyte-derived macrophages.
1993 Feb
Proteins in the heat shock-70 family specifically bind 25-hydroxyvitamin D3 and 17beta-estradiol.
1998 Apr
Calcidiol and PTH levels in women attending an osteoporosis program.
1999 Apr
A pilot study to assess the safety and efficacy of topical calcipotriol treatment in childhood psoriasis.
1999 Jul-Aug
Kidney microsomal 25- and 1alpha-hydroxylase in vitamin D metabolism: catalytic properties, molecular cloning, cellular localization and expression during development.
2002 Feb 28
Overview of general physiologic features and functions of vitamin D.
2004 Dec
Vitamin D(3) metabolism in human glioblastoma multiforme: functionality of CYP27B1 splice variants, metabolism of calcidiol, and effect of calcitriol.
2005 Aug 1
Retinoic acid via RARalpha inhibits the expression of 24-hydroxylase in human prostate stromal cells.
2005 Dec 30
Vitamin D metabolism in human prostate cells: implications for prostate cancer chemoprevention by vitamin D.
2006 Jul-Aug
Functional evolution of the vitamin D and pregnane X receptors.
2007 Nov 12
Enhanced steatosis by nuclear receptor ligands: a study in cultured human hepatocytes and hepatoma cells with a characterized nuclear receptor expression profile.
2010 Mar 30
The evolution of farnesoid X, vitamin D, and pregnane X receptors: insights from the green-spotted pufferfish (Tetraodon nigriviridis) and other non-mammalian species.
2011 Feb 3
Patents

Patents

JP4806519B2
14
JPH0586021A
3
JPS62263110A
3

Sample Use Guides

In Vivo Use Guide
The initial dose of RAYALDEE (calcifediol) extended-release capsules is 30 mcg administered orally once daily at bedtime. Serum calcium should be below 9.8 mg/dL before initiating treatment. Monitor serum calcium, phosphorus, 25-hydroxyvitamin D and intact parathyroid hormone (PTH) 3 months after starting therapy or changing dose. Increase the dose to 60 mcg once daily after 3 months if intact PTH is above the treatment goal. Ensure serum calcium is below 9.8 mg/dL, phosphorus is below 5.5 mg/dL and 25-hydroxyvitamin D is below 100 ng/mL before increasing the dose. Suspend dosing if intact PTH is persistently abnormally low, serum calcium is consistently above the normal range or serum 25­ hydroxyvitamin D is consistently above 100 ng/mL
Route of Administration: Oral
In Vitro Use Guide
Vitamin D metabolites down-regulated stimulated IL-8 only in those hyperinflammatory monocyte-derived macrophages, and only when used at high doses (>100 nM for Calcifediol).
Name Type Language
CALCIFEDIOL
EP   ORANGE BOOK   USAN   USP   USP-RS   VANDF   WHO-DD  
USAN  
Official Name English
CALCIFEDIOL [VANDF]
Common Name English
U-32070E
Code English
HIDROFEROL
Brand Name English
DIDROGYL
Brand Name English
CALCIFEDIOL [EP IMPURITY]
Common Name English
CALCIFEDIOL [ORANGE BOOK]
Common Name English
CALCIFEDIOL HYDRATE
Common Name English
CALCIFEDIOL [USAN]
Common Name English
U-32,070E
Code English
9,10-Secocholesta-5,7,10(19)-triene-3,25-diol, monohydrate, (3β,5Z,7E)-
Systematic Name English
25-Hydroxycholecalciferol monohydrate
Common Name English
1H-Indene-1-pentanol, 4-[(2Z)-2-[(5S)-5-hydroxy-2-methylenecyclohexylidene]ethylidene]octahydro-α,α,ε,7a-tetramethyl-, hydrate (1:1), (εR,1R,3aS,4E,7aR)-
Systematic Name English
CALCIFEDIOL [USP-RS]
Common Name English
Calcifediol monohydrate [WHO-DD]
Common Name English
CALDEROL
Brand Name English
CALCIFEDIOL [USP MONOGRAPH]
Common Name English
Calcifediol [WHO-DD]
Common Name English
Classification Tree Code System Code
LIVERTOX 138
Created by admin on Fri Dec 15 16:03:43 GMT 2023 , Edited by admin on Fri Dec 15 16:03:43 GMT 2023
NCI_THESAURUS C39713
Created by admin on Fri Dec 15 16:03:43 GMT 2023 , Edited by admin on Fri Dec 15 16:03:43 GMT 2023
WHO-ATC A11CC06
Created by admin on Fri Dec 15 16:03:43 GMT 2023 , Edited by admin on Fri Dec 15 16:03:43 GMT 2023
WHO-VATC QA11CC06
Created by admin on Fri Dec 15 16:03:43 GMT 2023 , Edited by admin on Fri Dec 15 16:03:43 GMT 2023
Code System Code Type Description
FDA UNII
P6YZ13C99Q
Created by admin on Fri Dec 15 16:03:43 GMT 2023 , Edited by admin on Fri Dec 15 16:03:43 GMT 2023
PRIMARY
DRUG BANK
DBSALT002443
Created by admin on Fri Dec 15 16:03:43 GMT 2023 , Edited by admin on Fri Dec 15 16:03:43 GMT 2023
PRIMARY
DAILYMED
P6YZ13C99Q
Created by admin on Fri Dec 15 16:03:43 GMT 2023 , Edited by admin on Fri Dec 15 16:03:43 GMT 2023
PRIMARY
PUBCHEM
6441383
Created by admin on Fri Dec 15 16:03:43 GMT 2023 , Edited by admin on Fri Dec 15 16:03:43 GMT 2023
PRIMARY
SMS_ID
300000038170
Created by admin on Fri Dec 15 16:03:43 GMT 2023 , Edited by admin on Fri Dec 15 16:03:43 GMT 2023
PRIMARY
RXCUI
1889
Created by admin on Fri Dec 15 16:03:43 GMT 2023 , Edited by admin on Fri Dec 15 16:03:43 GMT 2023
PRIMARY RxNorm
ChEMBL
CHEMBL1040
Created by admin on Fri Dec 15 16:03:43 GMT 2023 , Edited by admin on Fri Dec 15 16:03:43 GMT 2023
PRIMARY
DRUG CENTRAL
464
Created by admin on Fri Dec 15 16:03:43 GMT 2023 , Edited by admin on Fri Dec 15 16:03:43 GMT 2023
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WIKIPEDIA
CALCIFEDIOL
Created by admin on Fri Dec 15 16:03:43 GMT 2023 , Edited by admin on Fri Dec 15 16:03:43 GMT 2023
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CAS
63283-36-3
Created by admin on Fri Dec 15 16:03:43 GMT 2023 , Edited by admin on Fri Dec 15 16:03:43 GMT 2023
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NCI_THESAURUS
C65278
Created by admin on Fri Dec 15 16:03:43 GMT 2023 , Edited by admin on Fri Dec 15 16:03:43 GMT 2023
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CHEBI
17933
Created by admin on Fri Dec 15 16:03:43 GMT 2023 , Edited by admin on Fri Dec 15 16:03:43 GMT 2023
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MESH
D002112
Created by admin on Fri Dec 15 16:03:43 GMT 2023 , Edited by admin on Fri Dec 15 16:03:43 GMT 2023
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RS_ITEM_NUM
1086108
Created by admin on Fri Dec 15 16:03:43 GMT 2023 , Edited by admin on Fri Dec 15 16:03:43 GMT 2023
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SUBSTANCE RECORD
Structure of CALCIFEDIOL
NIH
NCATS
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ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
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