HEXOBENDINE DIHYDROCHLORIDE

Possibly Marketed Outside US

Details

Stereochemistry	ACHIRAL
Molecular Formula	C30H44N2O10.2ClH
Molecular Weight	665.6
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of HEXOBENDINE DIHYDROCHLORIDE

Structure Search

SMILES

Cl.Cl.COC1=CC(=CC(OC)=C1OC)C(=O)OCCCN(C)CCN(C)CCCOC(=O)C2=CC(OC)=C(OC)C(OC)=C2

InChI

InChIKey=GIOKUMNZQFCEPI-UHFFFAOYSA-N

InChI=1S/C30H44N2O10.2ClH/c1-31(11-9-15-41-29(33)21-17-23(35-3)27(39-7)24(18-21)36-4)13-14-32(2)12-10-16-42-30(34)22-19-25(37-5)28(40-8)26(20-22)38-6;;/h17-20H,9-16H2,1-8H3;2*1H

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/20501198 | https://www.ncbi.nlm.nih.gov/pubmed/1168469 | https://www.ncbi.nlm.nih.gov/pubmed/5331101 | https://www.ncbi.nlm.nih.gov/pubmed/4885101 | https://www.ncbi.nlm.nih.gov/pubmed/6056177

Hexobendine (Ustimon or ST7090) is a vasodilator. It inhibits uptake of adenosine and cAMP. Hexobendine was investigated in clinical trials for the treatment of cerebrovascular and coronary artery diseases.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Sodium channel alpha subunits; brain (Types I, II, III) 28 Target ID: CHEMBL2096682 Sources: https://www.ncbi.nlm.nih.gov/pubmed/2579237	Inhibitor 8504		1.4 µM [IC50]
adenosine metabolic process 2 Target ID: GO:0046085 Sources: https://www.ncbi.nlm.nih.gov/pubmed/1168469 \| https://www.ncbi.nlm.nih.gov/pubmed/744550	Modulator 846		0.7 µM [IC50]

PubMed

Title	Date	PubMed
Release of adenosine and ATP during ischemia and epilepsy.	2009-09	20190959
Short-term and long-term cognitive function and cerebral perfusion in off-pump and on-pump coronary artery bypass patients.	2006-01	16337804
[Use of instenon in complex treatment of patients with optic nerve atrophy caused by craniocerebral trauma].	2004-01-08	14708165
[Pharmacological prevention of cerebrovascular complications in cardiac patients after coronary artery bypass surgery].	2003	12830521
[The use of instenon in children with minimal brain dysfunction].	2002	12087730

Name

Type

Language

HEXOBENDINE DIHYDROCHLORIDE

Common Name

English

HEXOBENDINE HYDROCHLORIDE

Preferred Name

English

ANDIAMINE

Brand Name

English

Hexobendine hydrochloride [WHO-DD]

Common Name

English

USTIMON

Brand Name

English

ST-7090

Code

English

REOXYL

Brand Name

English

HEXOBENDINE DIHYDROCHLORIDE [MI]

Common Name

English

Code System Code Type Description

EVMPD

SUB35797