TESTOSTERONE 1,2,6,7-3H

Details

Stereochemistry	MIXED
Molecular Formula	C19H28O2
Molecular Weight	296.4569
Optical Activity	UNSPECIFIED
Defined Stereocenters	6 / 10
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@@]12CC[C@H](O)[C@@]1(C)CC[C@@]3([H])[C@@]2([H])C([3H])C([3H])C4=CC(=O)C([3H])C([3H])[C@]34C

InChI

InChIKey=MUMGGOZAMZWBJJ-JQSYSRDDSA-N

InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1/i3T,4T,7T,9T/t3?,4?,7?,9?,14-,15-,16-,17-,18-,19-

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/180014 | https://www.ncbi.nlm.nih.gov/pubmed/262766 | https://www.ncbi.nlm.nih.gov/pubmed/7435119 | http://www.perkinelmer.com/product/testosterone-1-2-6-7-3h-n-net370250uc

(1,2,6,7-3H)-Testosterone is a radiolabeled form of the corresponding steroid hormone. It can be used to study testosterone metabolism and androgen receptor binding in tissues.

CNS Activity

Approval Year

Targets

Primary Target	Pharmacology	Potency
Steroid 5-alpha-reductase 15 Target ID: CHEMBL2363075 Sources: https://www.ncbi.nlm.nih.gov/pubmed/262766 \| https://www.ncbi.nlm.nih.gov/pubmed/484635 \| https://www.ncbi.nlm.nih.gov/pubmed/7435119 \| https://www.ncbi.nlm.nih.gov/pubmed/262766	Substrate 661
Cytochrome P450 3A4 127 Target ID: CHEMBL340 Sources: https://www.ncbi.nlm.nih.gov/pubmed/9531515	Substrate 661
Androgen Receptor 167 Target ID: CHEMBL3072 Sources: https://www.ncbi.nlm.nih.gov/pubmed/180014 \| https://www.ncbi.nlm.nih.gov/pubmed/183742	Binding Agent 1064	2.0 nM [Kd]

Conditions

Condition	Modality	Targets	Highest Phase	Product
Unknown 2578

PubMed

Title	Date	PubMed
Sex-specific occurrence of androgen receptors in rat brain.	1976 Jul 10	180014
Relation of uptake and metabolism of (1,2,6,7-3H)testosterone to individual differences in sexual behavior in male guinea pigs.	1976 Mar 19	1252950
Testosterone metabolism of fibroblasts grown from prostatic carcinoma, benign prostatic hyperplasia and skin fibroblasts.	1982 Feb	6174738
Testosterone processing by pituitary cells in culture: an examination of the role of 5 alpha-reduction in androgen action on the gonadotroph.	1991 Jan	1903002

Sample Use Guides

In Vivo Use Guide

castrated male and female rats were given an intraperitoneal injection of 250 uCi of [1,2,6,7-3H]testosterone in 120 ul of acetone.

Route of Administration: Intraperitoneal

In Vitro Use Guide

After 24 h preincubation in serum-free Eagle's medium 199, 100-mm dishes of confluent dermal papilla cells from pubic and axillary hair follicles were incubated for 2 h with 5 nM [1,2,6,7-3H]testosterone.

Name

Type

Language

TESTOSTERONE 1,2,6,7-3H

Common Name

English

ANDROST-4-EN-3-ONE-1,2,6,7-T4, 17-HYDROXY-, (17.BETA.)-

Systematic Name

English

TESTOSTERONE, 1,2,6,7-H-3

Common Name

English

TESTOSTERONE, (1,2,6,7-3H)-

Common Name

English

(1,2,6,7-3H)-TESTOSTERONE

Common Name

English

Code System Code Type Description

PUBCHEM

91667979