Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C38H41N5O9 |
Molecular Weight | 711.7602 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 3 / 3 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CCC1=C(C)C2=CC3=C(C=C)C(C)=C(N3)C=C4N=C([C@@H](CCC(O)=O)[C@@H]4C)C(CC(=O)N[C@@H](CC(O)=O)C(O)=O)=C5NC(=CC1=N2)C(C)=C5C(O)=O
InChI
InChIKey=VSEIDZLLWQQJGK-WSUYNKMOSA-N
InChI=1S/C38H41N5O9/c1-7-20-16(3)24-12-26-18(5)22(9-10-32(45)46)35(42-26)23(11-31(44)41-30(37(49)50)15-33(47)48)36-34(38(51)52)19(6)27(43-36)14-29-21(8-2)17(4)25(40-29)13-28(20)39-24/h7,12-14,18,22,30,39,43H,1,8-11,15H2,2-6H3,(H,41,44)(H,45,46)(H,47,48)(H,49,50)(H,51,52)/b24-12-,25-13-,26-12-,27-14-,28-13-,29-14-,35-23-,36-23-/t18-,22-,30-/m0/s1
DescriptionSources: http://www.ncbi.nlm.nih.gov/pubmed/20001435Curator's Comment: description was created based on several sources, including
http://meeting.ascopubs.org/cgi/content/abstract/24/18_suppl/7229
Sources: http://www.ncbi.nlm.nih.gov/pubmed/20001435
Curator's Comment: description was created based on several sources, including
http://meeting.ascopubs.org/cgi/content/abstract/24/18_suppl/7229
Talaporfin (INN, also known as aspartyl chlorin, mono-L-aspartyl chlorin e6, NPe6, or LS11) is a photosensitizer used in photodynamic therapy (PDT). Talaporfin is injected into tumors and other regret tissues where it accumulates. It’s activated with light emitting diodes (LED). It absorbs red light at 664-667 nm normally provided by a laser tuned to this wavelength. It was approved in Japan (in 2004) for PDT of lung cancer and glioma and marketed as Laserphyrin. Clinical and preclinical studies indicate that talaporfin sodium treatment may offer a powerful option to synergize current therapies, as well as an alternative monotherapy in treating cancer.
Originator
Approval Year
Sample Use Guides
In Vivo Use Guide
Sources: http://www.ncbi.nlm.nih.gov/pubmed/23952800
single intravenous injection of talaporfin sodium (40 mg/m(2)) was administered 1 day before resection of the neoplasm
Route of Administration:
Intravenous
In Vitro Use Guide
Sources: http://www.ncbi.nlm.nih.gov/pubmed/25374373
combination of 30 µg/mL NPe6 (talaporfin sodium) with 5 J/cm(2) laser is the best treatment condition for inducing an increase in apoptotic cells while keeping rate of necrotic cell death low
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NCI_THESAURUS |
C1420
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300000037004
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P4ROX5ELT2
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m10436
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CHEMBL2111186
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110230-98-3
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TALAPORFIN
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DTXSID101318471
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5486799
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DB11812
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C053434
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7974
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C90923
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2555
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ACTIVE MOIETY