KINETIN

Possibly Marketed Outside US

Details

Stereochemistry	ACHIRAL
Molecular Formula	C10H9N5O
Molecular Weight	215.2114
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

C(NC1=C2N=CNC2=NC=N1)C3=CC=CO3

InChI

InChIKey=QANMHLXAZMSUEX-UHFFFAOYSA-N

InChI=1S/C10H9N5O/c1-2-7(16-3-1)4-11-9-8-10(13-5-12-8)15-6-14-9/h1-3,5-6H,4H2,(H2,11,12,13,14,15)

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/26502637 | https://pubs.acs.org/doi/abs/10.1021/ja01610a105 | https://www.drugs.com/npp/kinetin.html

Kinetin (6-furfuryladenine) is a biologically active natural phytochemical. It belongs to the category of cytokinins, the natural plant growth hormones that promote cell division and play role in cell differentiation. Kinetin functions as an essential growth hormone, which can influence cell growth and differentiation. It can delay and offset aging characteristics such as cell growth rate and size. It is claimed to reduce wrinkles and improve skin texture, telangiectasia, and mottled hyperpigmentation, although there is limited information to support this.

CNS Activity

Originator

Approval Year

Conditions

Condition	Modality	Highest Phase	Product
Alzheimer’s disease 272 Sources: https://www.ncbi.nlm.nih.gov/pubmed/28867383	Primary	Preclinical	Unknown Approved Use Unknown
Cutaneous photoaging 1 Sources: https://www.ncbi.nlm.nih.gov/pubmed/25994881 https://www.ncbi.nlm.nih.gov/pubmed/26502637 https://www.drugs.com/npp/kinetin.html	Primary	Phase IV 63	Unknown Approved Use Unknown
Cancer 592 Sources: https://www.ncbi.nlm.nih.gov/pubmed/15374684	Primary	Basic research	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
"Action-at-a distance" of a new DNA oxidative damage product 6-furfuryl-adenine (kinetin) on template properties of modified DNA.	2003 Feb 20	12591610
Kinetin-induced differentiation of normal human keratinocytes undergoing aging in vitro.	2006 May	16804007
Topical kinetin 0.1% lotion for improving the signs and symptoms of rosacea.	2007 Nov	17868391
Chloroplast transformation of rapeseed (Brassica napus) by particle bombardment of cotyledons.	2010 Apr	20179937
Acetazolamide-based fungal chitinase inhibitors.	2010 Dec 1	21044846
Olfactory stem cells, a new cellular model for studying molecular mechanisms underlying familial dysautonomia.	2010 Dec 20	21187979
Neuropharmacology of vestibular system disorders.	2010 Mar	20808544

Patents

Sample Use Guides

In Vivo Use Guide

0.1% kinetin cream twice daily for 12 weeks

Route of Administration: Transdermal

In Vitro Use Guide

addition of 40-200 uM kinetin in the culture medium of human diploid fibroblasts can both delay the onset and decrease the extent of many of the aging characteristics that appear during serial passaging of normal cells in culture.

Name

Type

Language

KINETIN

Official Name

English

6-(FURFURYLAMINO)PURINE

Systematic Name

English

FURFURYL(PURIN-6-YL)AMINE

Systematic Name

English

KINETIN [HSDB]

Common Name

English

N(SUP 6)-FURFURYLADENINE

Systematic Name

English

KINETIN [MI]

Common Name

English

KINETIN [INCI]

Common Name

English

Kinetin [WHO-DD]

Common Name

English

N6-FURFURYLADENINE

Systematic Name

English

KINETIN [MART.]

Common Name

English

N-(2-FURANYLMETHYL)-1H-PURIN-6-AMINE

Systematic Name

English

NSC-23119

Code

English

1H-PURIN-6-AMINE, N-(2-FURANYLMETHYL)-

Systematic Name

English

6-FURFURYLADENINE

Systematic Name

English

6-FURFURYLAMINOPURINE

Systematic Name

English

ADENINE, N-FURFURYL-

Systematic Name

English

Classification Tree Code System Code

EPA PESTICIDE CODE

116802