Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C44H80N2O15.2K.2H2O4P |
| Molecular Weight | 1149.2815 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 22 / 22 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[K+].[K+].OP(O)([O-])=O.OP(O)([O-])=O.CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(O)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@@H]([C@H]3O)N(C)C)[C@@](C)(C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O)O[C@H]4C[C@H]([C@@H](O)[C@H](C)O4)N(C)C
InChI
InChIKey=YVWJEFDUJZGAQS-CTMPRURZSA-L
InChI=1S/C44H80N2O15.2K.2H3O4P/c1-16-30-44(11,54)37(50)23(4)33(47)21(2)19-43(10,61-31-18-29(46(14)15)34(48)26(7)56-31)39(60-41-35(49)28(45(12)13)17-22(3)55-41)24(5)36(25(6)40(52)58-30)59-32-20-42(9,53)38(51)27(8)57-32;;;2*1-5(2,3)4/h21-32,34-39,41,48-51,53-54H,16-20H2,1-15H3;;;2*(H3,1,2,3,4)/q;2*+1;;/p-2/t21-,22-,23+,24+,25-,26+,27+,28+,29-,30-,31+,32+,34+,35-,36+,37-,38+,39-,41+,42-,43-,44-;;;;/m1..../s1
Megalomicin is a Micromonospora-produced macrolide antibiotic complex. Megalomicin A component was studied most extensively. It inhibited the ATP-dependent acidification of lysosomes and intra-Golgi transport in vitro. Megalomicin induces a powerful inhibitory effect on HIV-1 replication at nontoxic concentrations by preventing the processing of HIV-1 gp160 envelope protein and the subsequent formation of infectious viral particles.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Megalomicin inhibits HIV-1 replication and interferes with gp160 processing. | 1997-12-22 |
|
| Megalomicin disrupts lysosomal functions. | 1997-08 |
|
| Intra-Golgi transport inhibition by megalomicin. | 1996-02-16 |
|
| Biological activity of megalomicin A phosphate, a water-soluble salt of megalomicin A. | 1971-05 |
|
| Biological activity of megalomicin, a new Micromonospora-produced macrolide antibiotic complex. | 1969-06 |
| Name | Type | Language | ||
|---|---|---|---|---|
|
Preferred Name | English | ||
|
Official Name | English | ||
|
Common Name | English | ||
|
Code | English | ||
|
Common Name | English | ||
|
Code | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
31863
Created by
admin on Mon Mar 31 17:45:52 GMT 2025 , Edited by admin on Mon Mar 31 17:45:52 GMT 2025
|
PRIMARY | |||
|
CHEMBL2110742
Created by
admin on Mon Mar 31 17:45:52 GMT 2025 , Edited by admin on Mon Mar 31 17:45:52 GMT 2025
|
PRIMARY | |||
|
51481-68-6
Created by
admin on Mon Mar 31 17:45:52 GMT 2025 , Edited by admin on Mon Mar 31 17:45:52 GMT 2025
|
SUPERSEDED | |||
|
P368DJZ2JM
Created by
admin on Mon Mar 31 17:45:52 GMT 2025 , Edited by admin on Mon Mar 31 17:45:52 GMT 2025
|
PRIMARY | |||
|
300000055254
Created by
admin on Mon Mar 31 17:45:52 GMT 2025 , Edited by admin on Mon Mar 31 17:45:52 GMT 2025
|
PRIMARY | |||
|
C174829
Created by
admin on Mon Mar 31 17:45:52 GMT 2025 , Edited by admin on Mon Mar 31 17:45:52 GMT 2025
|
PRIMARY | |||
|
23319-48-4
Created by
admin on Mon Mar 31 17:45:52 GMT 2025 , Edited by admin on Mon Mar 31 17:45:52 GMT 2025
|
PRIMARY |
ACTIVE MOIETY
SUBSTANCE RECORD
