Details
Stereochemistry | ACHIRAL |
Molecular Formula | C16H15ClN2 |
Molecular Weight | 270.757 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CN1CCN=C(C2=CC=CC=C2)C3=C1C=CC(Cl)=C3
InChI
InChIKey=YLCXGBZIZBEVPZ-UHFFFAOYSA-N
InChI=1S/C16H15ClN2/c1-19-10-9-18-16(12-5-3-2-4-6-12)14-11-13(17)7-8-15(14)19/h2-8,11H,9-10H2,1H3
Medazepam is a benzodiazepine drug with anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties. It is known by the following brand names: Azepamid, Nobrium, Tranquirax (mixed with bevonium), Rudotel, Raporan, Ansilan and Mezapam. Marketed in Russia. Indicated for the treatment of neurotic disorders and states, accompanied with sense of fear, anxiety, intension, raised irritability, insomnia, vegetative lability.
CNS Activity
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
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Target ID: 1.00520936E8 Gene Symbol: NOS1 Sources: https://www.ncbi.nlm.nih.gov/pubmed/11731013 |
170.0 µM [IC50] | ||
Target ID: CHEMBL2093872 |
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Target ID: CHEMBL1907607 Sources: https://www.ncbi.nlm.nih.gov/pubmed/2993620 |
528.0 nM [Ki] |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
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Primary | Nobrium Approved UseThis medication is used in the treatment of anxiety disorders, alcohol withdrawal, tremor, muscle spasms and to control seizures. It may also be used before surgery or procedures to reduce apprehension and anxiety. |
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Primary | Nobrium Approved UseThis medication is used in the treatment of anxiety disorders, alcohol withdrawal, tremor, muscle spasms and to control seizures. It may also be used before surgery or procedures to reduce apprehension and anxiety. |
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Primary | Nobrium Approved UseThis medication is used in the treatment of anxiety disorders, alcohol withdrawal, tremor, muscle spasms and to control seizures. It may also be used before surgery or procedures to reduce apprehension and anxiety. |
PubMed
Title | Date | PubMed |
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Bromazepam, medazepam, chlordiazepoxide in treatment of neurotic anxiety. | 1974 May |
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Structural requirements of benzodiazepines for the inhibition of pig brain nitric oxide synthase. | 2001 Nov 30 |
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Substrate specificity of human 3(20)alpha-hydroxysteroid dehydrogenase for neurosteroids and its inhibition by benzodiazepines. | 2002 Apr |
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Quantitation using GC-TOF-MS: example of bromazepam. | 2002 Aug 14 |
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Oesophageal motility disorders. | 2002 Jan 12 |
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A population-based case-control teratologic study of nitrazepam, medazepam, tofisopam, alprazolum and clonazepam treatment during pregnancy. | 2002 Mar 10 |
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[Comprehensive medical and ecological studies in Pryel'brussi]. | 2003 |
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A study into the rate of incorporation of eight benzodiazepines into rat hair. | 2003 Apr 23 |
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Selective and potent inhibitors of human 20alpha-hydroxysteroid dehydrogenase (AKR1C1) that metabolizes neurosteroids derived from progesterone. | 2003 Feb 1 |
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Determination of clofazimine in leprosy patients by high-performance liquid chromatography. | 2003 Sep |
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Determination of diazepam in cream biscuits by liquid chromatography. | 2004 May-Jun |
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Cytokinin-binding protein (70 kDa): localization in tissues and cells of etiolated maize seedlings and its putative function. | 2007 |
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Separation of 1,4-benzodiazepines by micellar elektrokinetic capillary chromatography. | 2007 Jan 10 |
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Human resource management in the Georgian National Immunization Program: a baseline assessment. | 2007 Jul 31 |
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[Efficacy and possible mechanisms of action of a new peptide anxiolytic selank in the therapy of generalized anxiety disorders and neurasthenia]. | 2008 |
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The educational background and qualifications of UK medical students from ethnic minorities. | 2008 Apr 16 |
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Adverse drug effects in hospitalized elderly: data from the healthcare cost and utilization project. | 2010 |
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Development and validation of an EI-GC-MS method for the determination of benzodiazepine drugs and their metabolites in blood: applications in clinical and forensic toxicology. | 2010 Aug 1 |
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Framing access to medicines in developing countries: an analysis of media coverage of Canada's Access to Medicines Regime. | 2010 Jan 4 |
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Barriers to treatment adherence in physiotherapy outpatient clinics: a systematic review. | 2010 Jun |
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[Oxygen consumption by resting humans at different Elbrus altitudes]. | 2010 May-Jun |
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Daily functioning and self-management in patients with chronic low back pain after an intensive cognitive behavioral programme for pain management. | 2010 Sep |
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1-(1-Phenyl-ethyl-idene)carbonohydrazide. | 2010 Sep 30 |
Patents
Sample Use Guides
In Vivo Use Guide
Sources: http://omedicine.info/en/medazepam.html
The average dose for adults: single - 10-20 mg, the average daily - 20-30 mg, the maximum - 60-70 mg / day. At the beginning of treatment - for 5 mg 2-3 times a day, then gradually increase the dose to 30-40 mg per day. In outpatient settings recommended by 5 mg in the morning and in the afternoon, and 10 mg in the evening. Elderly patients, teenagers, as well as kidney function - 5-10 mg 1-2 times a day, or 10 mg at night. Babies dose depends on the age and body weight. Treatment duration should be as short as possible (about 2 Sun) and should not exceed 2 Months (including the period of gradual reduction of the dose).
Route of Administration:
Oral
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2859216
Medazepam (10 (-5) M) inhibited the contractile response of circular muscle strips from the isolated guinea-pig gallbladder to sulfated cholecystokinin octapeptide (CCK8) in the presence of atropine.
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NCI_THESAURUS |
C1012
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WHO-VATC |
QN05BA03
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WHO-ATC |
N05BA03
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DEA NO. |
2836
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SUB08689MIG
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220-783-4
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P0J3387W3S
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MEDAZEPAM
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4041
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CHEMBL28333
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C66068
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DB13437
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1654
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ACTIVE MOIETY
SALT/SOLVATE (PARENT)