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Details

Stereochemistry ACHIRAL
Molecular Formula C7H6NO2.Na
Molecular Weight 159.1178
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SALICYLAMIDE SODIUM

SMILES

[Na+].NC(=O)C1=C([O-])C=CC=C1

InChI

InChIKey=QPBKUJIATWTGHV-UHFFFAOYSA-M
InChI=1S/C7H7NO2.Na/c8-7(10)5-3-1-2-4-6(5)9;/h1-4,9H,(H2,8,10);/q;+1/p-1

HIDE SMILES / InChI

Description

Salicylamide is a non-prescription drug with analgesic and antipyretic properties (NSAID). It is used in combination with aspirin and caffeine in the over-the-counter pain remedies (such as EXAPRIN). Salicylamide can produce sedation and sleep in humans and animals. Has been used as model drug in pharmacokinetic and metabolic studies as a dophamine 2 receptor ligand. Salicylamide is a white or light pink crystals or powder. Organic compound it is a carboxamide derivative of salicylic acid.

CNS Activity

Approval Year

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
EXAPRIN
Primary
EXAPRIN

Cmax

ValueDoseCo-administeredAnalytePopulation
30.9 μg/mL
500 mg single, oral
SALICYLAMIDE plasma
Homo sapiens

AUC

ValueDoseCo-administeredAnalytePopulation
76 μg × min/mL
500 mg single, oral
SALICYLAMIDE plasma
Homo sapiens

T1/2

ValueDoseCo-administeredAnalytePopulation
12 min
500 mg single, oral
SALICYLAMIDE plasma
Homo sapiens

Overview

CYP3A4CYP2C9CYP2D6hERG


OverviewOther

Other InhibitorOther SubstrateOther Inducer





Drug as perpetrator​

PubMed

Sample Use Guides

In Vivo Use Guide
152 mg salicylamide/tablet: 1 - 2 tablets every 4 hours while sympotms persist (adults and children 12 years of age and over); no more than 8 tablets in 24 hours unless directed by a doctor. Not for use by children under 12 years.
Route of Administration: Oral
In Vitro Use Guide
Unknown