Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C4H4N2O2 |
| Molecular Weight | 113.0794 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
O=C1N[13C](=O)NC=C1
InChI
InChIKey=ISAKRJDGNUQOIC-AZXPZELESA-N
InChI=1S/C4H4N2O2/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8)/i4+1
Otsuka Pharmaceutical was developing URACIL C-13, 2- ([2-13C]uracil) breath test for diagnosis of cancer and gastric emptying disorders. Dihydropyrimidine dehydrogenase (DPD) deficiency is critical in the predisposition to 5-fluorouracil dose-related toxicity. The phenotypic [2-(13)C]uracil breath test (UraBT) demonstrated 96% specificity and 100% sensitivity for identification of DPD deficiency. Phase II development of the breath test was ongoing. As phase II clinical study didn't exploit performance as diagnostic medicines, the development of [2-13C]uracil was discontinued.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| The uracil breath test in the assessment of dihydropyrimidine dehydrogenase activity: pharmacokinetic relationship between expired 13CO2 and plasma [2-13C]dihydrouracil. | 2006-01-15 |
|
| Pharmacokinetic modelling of [2-13C]uracil metabolism in normal and DPD-deficient dogs. | 2006 |
|
| Rapid identification of dihydropyrimidine dehydrogenase deficiency by using a novel 2-13C-uracil breath test. | 2004-04-15 |
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35803-45-3
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DTXSID70189336
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10171240
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OZF8J4VAIK
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SUBSTANCE RECORD
