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Details

Stereochemistry ACHIRAL
Molecular Formula C22H25NO4.ClH
Molecular Weight 403.899
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DIMOXYLINE HYDROCHLORIDE

SMILES

Cl.CCOC1=CC=C(CC2=C3C=C(OC)C(OC)=CC3=CC(C)=N2)C=C1OC

InChI

InChIKey=MJBCABRMQNZIRC-UHFFFAOYSA-N
InChI=1S/C22H25NO4.ClH/c1-6-27-19-8-7-15(11-20(19)24-3)10-18-17-13-22(26-5)21(25-4)12-16(17)9-14(2)23-18;/h7-9,11-13H,6,10H2,1-5H3;1H

HIDE SMILES / InChI

Description
Curator's Comment: description was created based on several sources, including: https://www.ncbi.nlm.nih.gov/pubmed/14936209 | https://www.ncbi.nlm.nih.gov/pubmed/13240796 | https://www.ncbi.nlm.nih.gov/pubmed/13092557

Dimoxyline is the synthetic analogue of papaverine, Acute toxicity studies show it to be less toxic than papaverine. No analgesic action and no tolerance development in experimental animals by repeated administration. But Dimoxyline does not appear to be as potent as papaverine in comparable dosage. Dimoxyline is indicated for the treatment of patients with angina pectoris. Also, significant amount of benefit was claimed in patients with acute or chronic phlebitis, arterial thrombosis or embolism, Raynaud’s phenomena and early thromboangiitis obliterans or arteriosclerosis obliterans. Detected adverse events are: nausea or abdominal cramps.

Originator

Curator's Comment: # Eli Lilly

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Palliative
PAVERIL PHOSPHATE

Approved Use

Unknown

Launch Date

1953
Palliative
PAVERIL PHOSPHATE

Approved Use

Unknown

Launch Date

1953
Palliative
PAVERIL PHOSPHATE

Approved Use

Unknown

Launch Date

1953
PubMed

PubMed

TitleDatePubMed
Effects of dioxyline phosphate and enteric-coated khellin on coronary artery insufficiency.
1951 Jul
Studies on the use of dioxyline phosphate in the treatment of angina pectoris.
1952 Jul
Anginal relief with paveril phosphate.
1952 May
Papaverine analogs. 8. Comparative actions of papaverine, ethaverine and dioxyline on the cardiovascular system.
1960 Jul 1
Patents

Patents

Sample Use Guides

200 mg four times daily
Route of Administration: Oral
When the phosphate of the Dimoxyline was added to the Tyrode’s solution in which a strip of rabbit small intestine was suspended, a concentration of 1 :100,000 and 1200,000 caused a slight reduction in tone and a depression in the number of contractions per unit of time.
Name Type Language
DIMOXYLINE HYDROCHLORIDE
MI  
Common Name English
DIOXYLINE HYDROCHLORIDE
Common Name English
DIMOXYLINE HYDROCHLORIDE [MI]
Common Name English
ISOQUINOLINE, 1-((4-ETHOXY-3-METHOXYPHENYL)METHYL)-6,7-DIMETHOXY-3-METHYL-, HYDROCHLORIDE (1:1)
Systematic Name English
Code System Code Type Description
FDA UNII
OU67TQZ8RC
Created by admin on Sat Dec 16 06:08:18 GMT 2023 , Edited by admin on Sat Dec 16 06:08:18 GMT 2023
PRIMARY
MERCK INDEX
m147
Created by admin on Sat Dec 16 06:08:18 GMT 2023 , Edited by admin on Sat Dec 16 06:08:18 GMT 2023
PRIMARY Merck Index
CAS
5807-56-7
Created by admin on Sat Dec 16 06:08:18 GMT 2023 , Edited by admin on Sat Dec 16 06:08:18 GMT 2023
PRIMARY
PUBCHEM
22056
Created by admin on Sat Dec 16 06:08:18 GMT 2023 , Edited by admin on Sat Dec 16 06:08:18 GMT 2023
PRIMARY
EPA CompTox
DTXSID40973648
Created by admin on Sat Dec 16 06:08:18 GMT 2023 , Edited by admin on Sat Dec 16 06:08:18 GMT 2023
PRIMARY