ISONIAZID GLUCURONATE SODIUM ANHYDROUS

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C12H14N3O7.Na
Molecular Weight	335.2452
Optical Activity	UNSPECIFIED
Defined Stereocenters	4 / 4
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure of ISONIAZID GLUCURONATE SODIUM ANHYDROUS

Structure Search

SMILES

[Na+].O[C@@H](\C=N\NC(=O)C1=CC=NC=C1)[C@@H](O)[C@H](O)[C@H](O)C([O-])=O

InChI

InChIKey=DOIZJGJXNCMGLO-NOOPLZLZSA-M

InChI=1S/C12H15N3O7.Na/c16-7(8(17)9(18)10(19)12(21)22)5-14-15-11(20)6-1-3-13-4-2-6;/h1-5,7-10,16-19H,(H,15,20)(H,21,22);/q;+1/p-1/b14-5+;/t7-,8+,9-,10-;/m0./s1

HIDE SMILES / InChI

Description
Sources: http://www.drugbank.ca/drugs/DB00951 | https://www.jstage.jst.go.jp/article/joh1959/2/1/2_1_6/_article | https://www.ncbi.nlm.nih.gov/pubmed/2584297

Isoniazid glucuronate is a less toxic derivative the antibacterial drug isoniazid. Isoniazid is recommended for all forms of tuberculosis in which organisms are susceptible. Isoniazid itself is a prodrug and must be activated by bacterial catalase. Isoniazid inhibits InhA, the enoyl reductase from Mycobacterium tuberculosis, by forming a covalent adduct with the NAD cofactor.

Approval Year

Name

Type

Language

ISONIAZID GLUCURONATE SODIUM ANHYDROUS

Common Name

English

D-GLUCURONIC ACID, 1-((4-PYRIDINYLCARBONYL)HYDRAZONE), MONOSODIUM SALT

Common Name

English

GLYCONIAZIDE SODIUM

Common Name

English

GLUCURONIC ACID, 1-((4-PYRIDYLCARBONYL)HYDRAZONE), MONOSODIUM SALT, D-

Common Name

English

Glyconiazide sodium [WHO-DD]

Common Name

English

SODIUM GLUCURONATE ISONICOTINYL HYDRAZONE

Common Name

English

ISONICOTINIC ACID HYDRAZIDE, HYDRAZONE WITH D-GLUCURONIC ACID MONOSODIUM SALT

Common Name

English

ISONIAZID SODIUM GLUCURONATE

Common Name

English

ISONICOTINIC ACID HYDRAZIDE SODIUM GLUCURONATE

Common Name

English

SODIUM GLUCURONATE ISONICOTINOYLHYDRAZONE

Common Name

English

NSC-54041

Code

English

GLUCURONIC ACID, 1-(ISONICOTINOYLHYDRAZONE), MONOSODIUM SALT, D-

Common Name

English

Isoniazid sodium glucuronate [WHO-DD]

Common Name

English

Code System Code Type Description

PUBCHEM

70683039