Details
Stereochemistry | ACHIRAL |
Molecular Formula | CH4 |
Molecular Weight | 16.0425 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
C
InChI
InChIKey=VNWKTOKETHGBQD-UHFFFAOYSA-N
InChI=1S/CH4/h1H4
Biologically, methanogens in the colon can use carbon dioxide and hydrogen to produce methane as a by-product. It was previously considered that humans do not utilize methane. However, in a recent study on rodents, results demonstrated that methane could exert anti-inflammatory, anti-oxidant and anti-apoptotic effects. Furthermore, it has bee suggested, that methane-rich saline could be a promising therapeutic agent for clinical treatment of pancreatitis. Methane gas may also be a promising option for the clinical treatment of Acute Lung Injury and Spinal Cord Injury. The exact mechanism underlying the antioxidative, anti-inflammatory, and antiapoptotic activities of methane is not obvious. Different researchers have proposed different hypotheses. Some have hypothesized that methane might accumulate transiently at the interfaces of cell membranes, thereby changing the physicochemical properties or the in-situ functionality of proteins embedded within this environment. Other investigators have suggested that methane could exert effects on membrane channels affecting G-proteins, membrane or receptor-mediated signaling, or acetylcholine-activated ion channel kinetics. It is unknown if mammalian cells contain an oxygenase that is capable of using methane as a substrate, or if the biological effects of methane are caused by the formation of small amounts of the reactive alcohol, methanol, and/or changes in the redox milieu of the cell due to changes in NAD(P)+/NAD(P)H ratio, and whether or not there is a cellular “receptor” for methane. There are also questions remaining around the difference between intraperitoneal vs inhaled administration of methane.
Approval Year
PubMed
Title | Date | PubMed |
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Crystal structure of a bacterial non-haem iron hydroxylase that catalyses the biological oxidation of methane. | 1993 Dec 9 |
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Inhibition of methanogenesis by human bile. | 1995 Sep |
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Crystal structure of methyl-coenzyme M reductase: the key enzyme of biological methane formation. | 1997 Nov 21 |
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Fructans of chicory: intestinal transport and fermentation of different chain lengths and relation to fructose and sorbitol malabsorption. | 1998 Aug |
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Decompression sickness risk in rats by microbial removal of dissolved gas. | 1998 Sep |
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Interactions of D2O with methane and fluoromethane surfaces. | 2004 Mar 22 |
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Calcium structural transition of human cardiac troponin C in reconstituted muscle fibres as studied by site-directed spin labelling. | 2005 Apr 22 |
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Infrared spectra of CH3-CrH, CH3-WH, CH2=WH2, and CH[triple bond]WH3 formed by activation of CH4 with Cr and W atoms. | 2005 Oct 17 |
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Infrared spectrum and bonding in uranium methylidene dihydride, CH2=UH2. | 2007 Jun 11 |
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Diesel and biodiesels induce hepatic palmitoyl-CoA oxidase enzymatic activity through different molecular mechanisms in rats. | 2012 Jun |
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/28740568
in rats: methane-rich saline (MS) was injected intraperitoneally in rats after spinal cord injury (SCI). Hematoxylin-eosin (HE) staining, oxidative stress, inflammatory parameters, and cell apoptosis were detected 72 h after SCI to determine the optimal dose. According to calculation, the concentration of MS was 0.99 mmol/l.
Route of Administration:
Intraperitoneal
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METHANE
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SUBSTANCE RECORD