Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C4H11NO2.ClH |
| Molecular Weight | 141.597 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.OCCNCCO
InChI
InChIKey=VJLOFJZWUDZJBX-UHFFFAOYSA-N
InChI=1S/C4H11NO2.ClH/c6-3-1-5-2-4-7;/h5-7H,1-4H2;1H
Diethanolamine (DEA) is an amino alcohol commonly used in the preparation of soaps and surfactants, agricultural chemicals and in textile processing. DEA and DEA-Derivatives are used in other products besides cosmetics and personal care products. For example, DEA and DEA-derivatives have been approved for several food-related applications, primarily food packaging.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| NTP Toxicology and Carcinogenesis Studies of Lauric Acid Diethanolamine Condensate (CAS NO. 120-40-1) in F344/N Rats and B6C3F1 Mice (Dermal Studies). | 1999 Jul |
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| Alkaline phosphatase activity: new assay for the Reflotron system. Results of the evaluation in eight clinical laboratories. | 2001 Jan |
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| [Effects of toxic substances on opportunistic microorganisms]. | 2002 Jan-Feb |
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| Evaluation of the impurity profile of alcuronium by means of capillary electrophoresis. | 2002 Jun 1 |
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| The unusually high proton affinity of aza-18-crown-6 ether: implications for the molecular recognition of lysine in peptides by lariat crown ethers. | 2002 May |
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| Diethanolamine induces hepatic choline deficiency in mice. | 2002 May |
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| The effect of ovary implants on juvenile hormone production by corpora allata of male Diploptera punctata. | 2003 |
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| Patch testing with components of water-based metalworking fluids. | 2003 Aug |
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| Design, synthesis, and biological evaluation of indenoisoquinoline topoisomerase I inhibitors featuring polyamine side chains on the lactam nitrogen. | 2003 Dec 18 |
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| Absorption and reaction kinetics of amines and ammonia solutions with carbon dioxide in flue gas. | 2003 Feb |
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| Percentage of the positive area of bone metastasis is an independent predictor of disease death in advanced prostate cancer. | 2003 Jan 27 |
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| Theoretical scales of hydrogen bond acidity and basicity for application in QSAR/QSPR studies and drug design. Partitioning of aliphatic compounds. | 2004 May-Jun |
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| Assembling novel heterotrimetallic Cu/Co/Ni and Cu/Co/Cd cores supported by diethanolamine ligand in one-pot reactions of zerovalent copper with metal salts. | 2004 Nov 29 |
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| In vitro human skin penetration of diethanolamine. | 2004 Oct |
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| A functional variant of Fcgamma receptor IIIA is associated with rheumatoid arthritis in individuals who are positive for anti-glucose-6-phosphate isomerase antibodies. | 2005 |
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| Chemical-induced atrial thrombosis in NTP rodent studies. | 2005 |
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| Characterization of spontaneous and chemically induced cardiac lesions in rodent model systems: the national toxicology program experience. | 2005 |
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| Anti-Sa antibodies and antibodies against cyclic citrullinated peptide are not equivalent as predictors of severe outcomes in patients with recent-onset polyarthritis. | 2005 |
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| Evaluation of alkaline phosphatase activity assay for the Reflotron system after substitution of the comparison method. | 2005 |
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| Review of the carcinogenic activity of diethanolamine and evidence of choline deficiency as a plausible mode of action. | 2005 Dec |
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| Simultaneous determination of inorganic anions and organic acids in amine solutions for sour gas treatment by capillary electrophoresis with indirect UV detection. | 2005 Dec 30 |
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| Brainstem levels of transcription factor AP-2 in rat are changed after treatment with phenelzine, but not with citalopram. | 2005 Jan 21 |
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| Prediction of genotoxicity of chemical compounds by statistical learning methods. | 2005 Jun |
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| Postnatal development of rat pups after maternal exposure to diethanolamine. | 2005 Jun |
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| The allergy adjuvant effect of particles - genetic factors influence antibody and cytokine responses. | 2005 Jun 21 |
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| Determination of diethanolamine in shampoo products containing fatty acid diethanolamides by liquid chromatography with a thermal energy analyzer. | 2005 Mar-Apr |
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| Determination of novel complexing agents in pulp and paper mill effluents and in lake water by liquid chromatography. | 2005 Nov 11 |
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| Ecotoxicological evaluation of diethanolamine using a battery of microbiotests. | 2005 Oct |
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| Species differences in the induction of hepatocellular DNA synthesis by diethanolamine. | 2005 Oct |
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| Mechanistic explanation to the catalysis by pyrazinamide and ethambutol of reaction between rifampicin and isoniazid in anti-TB FDCs. | 2005 Oct 4 |
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| Impairment of chondrocyte biosynthetic activity by exposure to 3-tesla high-field magnetic resonance imaging is temporary. | 2006 |
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| Diethanolamine and phenobarbital produce an altered pattern of methylation in GC-rich regions of DNA in B6C3F1 mouse hepatocytes similar to that resulting from choline deficiency. | 2006 Apr |
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| Diethanolamine alters neurogenesis and induces apoptosis in fetal mouse hippocampus. | 2006 Aug |
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| A heterotrimetallic Cu-Co-Zn complex with the 2,2'-iminodiethanol ligand. | 2006 Jun |
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| Cholesterol synthesis inhibitors protect against platelet-activating factor-induced neuronal damage. | 2007 Jan 18 |
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| Simultaneous monitoring of inorganic cations, amines and amino acids in human sweat by capillary electrophoresis. | 2007 Jan 2 |
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| Repeated dose toxicity and developmental toxicity of diisopropanolamine to rats. | 2007 Oct |
|
| Use of high-boiling point organic solvents for pulping oil palm empty fruit bunches. | 2008 Apr |
Patents
Sample Use Guides
MICE: Groups of 50 male and 50 female mice were administered 0, 40, 80, or 160 mg diethanolamine/kg body weight in ethanol dermally for 2 years. In male mice, the incidences of hepatocellular adenoma and of hepatocellular adenoma or carcinoma (combined) in all dosed groups and of hepatocellular carcinoma and hepatoblastoma in 80 and 160 mg/kg males were significantly increased compared to the vehicle controls.
Route of Administration:
Other
Sperm suspension was incubated with different concentrations (100–500 ug/mL) of diethanolamine to evaluate sperm parameters such as sperm motility, sperm viability and sperm morphology. diethanolamine caused significant decrease in sperm motility and sperm viability which was concentration and time–dependent.
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OI45OUW092
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14426-21-2
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26688
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238-396-4
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DTXSID10884752
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SUBSTANCE RECORD
