APAXIFYLLINE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C16H22N4O3
Molecular Weight	318.3709
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCCN1C2=C(NC(=N2)[C@H]3CCC(=O)C3)C(=O)N(CCC)C1=O

InChI

InChIKey=RUHGOZFOVBMWOO-JTQLQIEISA-N

InChI=1S/C16H22N4O3/c1-3-7-19-14-12(15(22)20(8-4-2)16(19)23)17-13(18-14)10-5-6-11(21)9-10/h10H,3-9H2,1-2H3,(H,17,18)/t10-/m0/s1

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Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/9203562 | https://adisinsight.springer.com/drugs/800004779 | https://www.yourdictionary.com/apaxifylline

Apaxifylline is an adenosine A1 receptor antagonist that was under investigation with Boehringer Ingelheim as a potential neuroprotective drug for the treatment of dementia. Apaxifylline was able to antagonize scopolamine-induced deficits in the rat in a memory task. A single oral application of apaxifylline 90 min before the rats received the noxious stimulus significantly attenuated the scopolamine-induced deficits observed during the retention trial of the rat in the passive avoidance paradigm. Apaxifylline treatment does not influence motility.

Approval Year

Sample Use Guides

In Vivo Use Guide

Single dose 1 mg/kg and 3 mg/kg

Route of Administration: Oral

Name

Type

Language

APAXIFYLLINE

Official Name

English

apaxifylline [INN]

Common Name

English

BIIP20XX

Code

English

(-)-(S)-8-(3-OXOCYCLOPENTYL)-1,3-DIPROPYLXANTHINE

Systematic Name

English

APAXIFYLLINE [USAN]

Common Name

English

BLIP-20-XX

Code

English

BIIP-20XX

Code

English

1H-PURINE-2,6-DIONE, 3,7-DIHYDRO-8-(3-OXOCYCLOPENTYL)-1,3-DIPROPYL-, (S)-

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C1509