NEMIRALISIB

Details

Stereochemistry	ACHIRAL
Molecular Formula	C26H28N6O
Molecular Weight	440.5401
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)N1CCN(CC2=CN=C(O2)C3=CC(=CC4=C3C=NN4)C5=CC=CC6=C5C=CN6)CC1

InChI

InChIKey=MCIDWGZGWVSZMK-UHFFFAOYSA-N

InChI=1S/C26H28N6O/c1-17(2)32-10-8-31(9-11-32)16-19-14-28-26(33-19)22-12-18(13-25-23(22)15-29-30-25)20-4-3-5-24-21(20)6-7-27-24/h3-7,12-15,17,27H,8-11,16H2,1-2H3,(H,29,30)

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/28823947 | https://clinicaltrials.gov/ct2/show/NCT02593539 | https://clinicaltrials.gov/ct2/show/NCT03345407

GSK-2269557 (nemiralisib), a PI3Kδ inhibitor, is in development as an anti-inflammatory drug for the treatment of inflammatory airways disease. Studies in moderate or severe stable COPD patients have shown an acceptable safety and tolerability profile when GSK-2269557 was administered via inhalation. Cough was the most commonly reported adverse event.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
PI3-kinase p110-delta subunit 43 Target ID: CHEMBL3130 Sources: https://www.ncbi.nlm.nih.gov/pubmed/22924688\|https://www.ncbi.nlm.nih.gov/pubmed/26301626	Inhibitor 8297		9.9 null [pKi]

Patents

Name

Type

Language

NEMIRALISIB

Official Name

English

nemiralisib [INN]

Common Name

English

GSK-2269557A

Code

English

6-(1H-INDOL-4-YL)-4-(5-((4-(1-METHYLETHYL)-1-PIPERAZINYL)METHYL)-2-OXAZOLYL)-1H-INDAZOLE

Systematic Name

English

6-(1H-INDOL-4-YL)-4-(5-((4-(1-METHYLETHYL)-1-PIPERAZINYL)METHYL)-1,3-OXAZOL-2-YL)-1H-INDAZOLE

Systematic Name

English

NEMIRALISIB [USAN]

Common Name

English

GSK2269557A

Code

English

Nemiralisib [WHO-DD]

Common Name

English

1H-INDAZOLE, 6-(1H-INDOL-4-YL)-4-(5-((4-(1-METHYLETHYL)-1-PIPERAZINYL)METHYL)-2-OXAZOLYL)-

Systematic Name

English

GSK-2269557 FREE BASE

Code

English

Code System Code Type Description

SMS_ID

100000175715