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Details

Stereochemistry ACHIRAL
Molecular Formula C14H18N2O
Molecular Weight 230.3055
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PROPYPHENAZONE

SMILES

CC(C)C1=C(C)N(C)N(C1=O)C2=CC=CC=C2

InChI

InChIKey=PXWLVJLKJGVOKE-UHFFFAOYSA-N
InChI=1S/C14H18N2O/c1-10(2)13-11(3)15(4)16(14(13)17)12-8-6-5-7-9-12/h5-10H,1-4H3

HIDE SMILES / InChI

Description

Propyphenazone is a pyrazolone derivative with anti-inflammatory, analgesic and antipyretic activity. The coupling of propyphenazone with other widely used acidic NSAIDs such as ketoprofen, ibuprofen, and diclofenac produced mutual prodrugs with synergistic analgesic effects. It was introduced for the treatment of different types of pain and fever and rheumatic disorders. Propyphenazone structurally relates to aminophenazone it has been associated with severe blood dyscrasias.

Originator

Approval Year

Targets

Primary TargetPharmacologyConditionPotency

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
saridon
Primary
saridon
Primary
saridon
Primary
saridon
Primary
saridon

PubMed

Sample Use Guides

In Vivo Use Guide
single oral doses of 150 and 300 mg
Route of Administration: Oral
In Vitro Use Guide
Unknown