ROLAFAGREL

Details

Stereochemistry	ACHIRAL
Molecular Formula	C14H12N2O2
Molecular Weight	240.2573
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC(=O)C1=CC2=C(CCC(=C2)N3C=CN=C3)C=C1

InChI

InChIKey=DQEDSIVMYUUZCK-UHFFFAOYSA-N

InChI=1S/C14H12N2O2/c17-14(18)11-2-1-10-3-4-13(8-12(10)7-11)16-6-5-15-9-16/h1-2,5-9H,3-4H2,(H,17,18)

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/7867681 | https://www.ncbi.nlm.nih.gov/pubmed/8473553 | https://www.ncbi.nlm.nih.gov/pubmed/1825400 | https://adisinsight.springer.com/drugs/800001438

Rolafagrel (FCE 22178) is a selective thromboxane synthase inhibitor that has been evaluated for use in the treatment of diabetic nephropathy and thrombosis. Rolafagrel inhibits platelet and glomerular thromoxane synthase in animal and human kidney disease. A phase I clinical trial did not report drug-related adverse events. No information is available on current use of rolafagrel.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Thromboxane-A synthase 21 Target ID: P24557\|\|\|Q8IUN1\|\|\|Q9HD82 Gene ID: 6916.0 Gene Symbol: TBXAS1 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/8473553	Inhibitor 8504

PubMed

Title	Date	PubMed
Regulatory role of eicosanoids in extracellular matrix overproduction induced by long-term exposure to high glucose in cultured rat mesangial cells.	1996-09	8877289

Patents

Name

Type

Language

ROLAFAGREL

Official Name

English

Rolafagrel [WHO-DD]

Preferred Name

English

rolafagrel [INN]

Common Name

English

5,6-DIHYDRO-7-IMIDAZOL-1-YL-2-NAPHTHOIC ACID

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C471