DELORAZEPAM

Investigational

Details

Stereochemistry	ACHIRAL
Molecular Formula	C15H10Cl2N2O
Molecular Weight	305.159
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

ClC1=CC=C2NC(=O)CN=C(C3=CC=CC=C3Cl)C2=C1

InChI

InChIKey=CHIFCDOIPRCHCF-UHFFFAOYSA-N

InChI=1S/C15H10Cl2N2O/c16-9-5-6-13-11(7-9)15(18-8-14(20)19-13)10-3-1-2-4-12(10)17/h1-7H,8H2,(H,19,20)

HIDE SMILES / InChI

Description
Sources: https://www.nutrizioneesalute.it/farmaci/en-delorazepam | https://www.codifa.it/farmaci/e/en-compressa-gocce-delorazepam-ansiolitici-benzodiazepinici | https://www.caymanchem.com/product/15938

Delorazepam is a benzodiazepine with anxiolytic effects. It is a metabolite of the designer drug diclazepam that can be detected in either the serum or urine. Delorazepam can also be produced by enzymatic treatment of lorazepam with β-glucuronidase. It is indicated for the treatment of anxiety, tension and other somatic or psychiatric manifestations associated with anxiety syndrome, insomnia. The side effects and precautions for use of delorazepam are the same as for all benzodiazepines, in particular as regards the development of dependence (mental and physical) and tolerance. Prolonged use may lead to difficulties remembering recent names and events (anterograde amnesia). It has been approved for marketing in Italy.

Approval Year

PubMed

Title	Date	PubMed
Quantification of chlordesmethyldiazepam by liquid chromatography-tandem mass spectrometry: application to a cloxazolam bioequivalence study.	2009-12	19488979
Treatment with aripiprazole and topiramate in an obese subject with borderline personality disorder, obsessive-compulsive symptoms and bulimia nervosa: a case report.	2009-07-23	19829941
GABA(A) receptors in normal development and seizures: friends or foes?	2008-03	19305785
An observational study in psychiatric acute patients admitted to General Hospital Psychiatric Wards in Italy.	2007-01-27	17257438
SPME-LC with UV detection to study delorazepam-serum albumin interactions.	2002-07-31	12093523
Determination of delorazepam in urine by solid-phase microextraction coupled to high performance liquid chromatography.	2002-06-01	12039639
Psychotic affective disorder after nicotine withdrawal.	1994-03	8109663
Participation of GABAergic mechanisms in the hypotensive and bradycardic effects of clonidine: experimental study in conscious normotensive and hypertensive rats.	1987-10	3683766

Patents

Sample Use Guides

In Vivo Use Guide

Anxiety: 1 tablet of 0.5-1 mg 2-3 times a day Insomnia: 1 tablet of 0.5-1-2 mg in the evening before bedtime.

Route of Administration: Oral

Name

Type

Language

DADUMIR

Preferred Name

English

DELORAZEPAM

Official Name

English

CHLORDESMETHYLDIAZEPAM

Common Name

English

7-CHLORO-5-(O-CHLOROPHENYL)-1,3-DIHYDRO-2H-1,4-BENZODIAZEPIN-2-ONE

Common Name

English

DELORAZEPAM [MART.]

Common Name

English

delorazepam [INN]

Common Name

English

NSC-169895

Code

English

Delorazepam [WHO-DD]

Common Name

English

Classification Tree Code System Code

DEA NO.

2754