THYMOQUINONE

Investigational

CC(C)C1=CC(=O)C(C)=CC1=O

InChIKey=KEQHJBNSCLWCAE-UHFFFAOYSA-N

InChI=1S/C10H12O2/c1-6(2)8-5-9(11)7(3)4-10(8)12/h4-6H,1-3H3

Targets

Primary Target	Pharmacology	Potency
Serine/threonine-protein kinase PLK1 14 Target ID: CHEMBL3024 Sources: https://www.ncbi.nlm.nih.gov/pubmed/25556101	Inhibitor 8297	2.18 µM [IC50]
DNA (cytosine-5)-methyltransferase 1 10 Target ID: CHEMBL1993 Sources: https://www.ncbi.nlm.nih.gov/pubmed/28415607	Inhibitor 8297	30.0 nM [IC50]
Neuronal acetylcholine receptor protein alpha-7 subunit 77 Target ID: CHEMBL2492 Sources: https://www.ncbi.nlm.nih.gov/pubmed/26849939	Antagonist 2778	4.4 µM [IC50]
Cytochrome P450 2C9 50 Target ID: CHEMBL3397 Sources: https://www.ncbi.nlm.nih.gov/pubmed/29989011	Inhibitor 8297	0.5 µM [IC50]
Tubulin 69 Target ID: CHEMBL2095182 Sources: https://www.ncbi.nlm.nih.gov/pubmed/24113316	Inhibitor 8297	1.19 µM [Kd]

PubMed

Title	Date	PubMed
Thymoquinone from Nigella sativa Seeds Promotes the Antitumor Activity of Noncytotoxic Doses of Topotecan in Human Colorectal Cancer Cells in Vitro.	2016 Mar	26848703

Name

Type

Language

THYMOQUINONE

Common Name

English

2,5-CYCLOHEXADIENE-1,4-DIONE, 2-METHYL-5-(1-METHYLETHYL)-

Systematic Name

English

Thymoquinone [WHO-DD]

Common Name

English

P-MENTHA-3,6-DIENE-2,5-DIONE

Common Name

English

P-CYMENE-2,5-DIONE

Common Name

English

THYMOQUINON

Common Name

English

NSC-2228

Code

English

Code System Code Type Description

CAS

490-91-5