U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula H2O4S
Molecular Weight 98.078
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of Sulfuric acid

SMILES

OS(O)(=O)=O

InChI

InChIKey=QAOWNCQODCNURD-UHFFFAOYSA-N
InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)

HIDE SMILES / InChI

Description

SULFATE (as sodium sulfate, potassium sulfate, and magnesium sulfate) is a component of SUPREP Bowel Prep Kit. It is an osmotic laxative indicated for cleansing of the colon in preparation for colonoscopy in adults. Sulfate salts provide sulfate anions, which are poorly absorbed. The osmotic effect of unabsorbed sulfate anions and the associated cations causes water to be retained within the gastrointestinal tract. SUPREP Bowel Prep Kit, when ingested with a large volume of water, produces copious watery diarrhea.

Approval Year

1921
1467
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Palliative
Approved
8429
SUPREP Bowel Prep Kit

Approved Use

SUPREP Bowel Prep Kit is an osmotic laxative indicated for cleansing of the colon in preparation for colonoscopy in adults.

Launch Date

2010
PubMed

PubMed

TitleDatePubMed
Patterns of sulphation in heparan sulphate: polymorphism based on a common structural theme.
1992 Apr
Dextran sulphate induces a PKC and actin independent internalisation of CD4.
1994 Sep
Two selectins converge on sulphate. Leukocyte adhesion.
1996 Mar 1
Structure-activity relationship of heparan sulphate.
1997 Nov
Dopamine sulphate: an enigma resolved.
1999 Apr
Heparan sulphate. Regulation of growth factors in the mammary gland.
2000
Magnesium sulphate for eclampsia: putting the evidence into clinical practice.
2000 Jun
Magnesium sulphate versus lytic cocktail for eclampsia.
2001
[Magnesium sulphate in the treatment of ischemic-hypoxic neonatal encephalopathy].
2001 Mar-Apr
Chondroitin sulphate proteoglycans in the CNS injury response.
2002
Magnesium sulphate and other anticonvulsants for women with pre-eclampsia.
2003
Hepatocyte growth factor/scatter factor and its interaction with heparan sulphate and dermatan sulphate.
2003 Apr
Heparan sulphate N-sulphotransferase activity: reaction mechanism and substrate recognition.
2003 Apr
Heparan sulphate proteoglycans in Alzheimer's disease and amyloid-related disorders.
2003 Aug
Intravenous magnesium sulphate in acute myocardial infarction--is the answer "MAGIC"?
2003 Mar
Characterization of the Herpesvirus saimiri Orf51 protein.
2004 Aug 15
[The extracellular matrix of the central nervous system: chondroitin sulphate type proteoglycans and neural repair].
2004 May 1-15
Epidemiology of 377 patients with chemical burns in Guangdong province.
2004 Sep
A meta-analysis on intravenous magnesium sulphate for treating acute asthma.
2005 Jan
Heparan sulphate proteoglycans: the sweet side of development.
2005 Jul
Chondroitin sulphate: antioxidant properties and beneficial effects.
2006 Dec
[Magnesium sulphate for the management of preeclampsia].
2006 Jan
The role of heparan sulphate proteoglycans in angiogenesis.
2006 Jun
Insights into the role of heparan sulphate in fibroblast growth factor signalling.
2006 Jun
Dietary acidification enhances phosphorus digestibility but decreases H+/K+-ATPase expression in rainbow trout.
2006 Oct
[Therapy of osteoarthritis crystalline glucosamine sulphate/a review of the clinical effcacy].
2007
Cholesterol sulfate as a potential inhibitor of hepatitis C virus NS3 helicase.
2014 Apr
Patents

Patents

03931143
17
03931217
10
03931218
7
03931239
39
03931412
37
03932479
112
03932483
74
03932505
8
03932630
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03939185
7
03940407
8
03940411
9
03943151
7
03943154
9
03946008
8
03947582
12
03966830
12
03983253
7
03992189
8
04001300
7
04013695
7
04016182
7
04028419
7
04036979
10
04049659
8
04052511
8
04055602
7
04061771
12
04066543
7
04073798
8
04078006
9
04086278
7
04086338
8
04105776
10
04124601
7
04128653
7
04154840
19
04154937
7
04156670
8
04160657
7
04164543
14
04171447
7
04190433
7
04191830
8
04205178
7
04229207
7
04242265
8
04273704
7
04278808
7
04324729
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04337197
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04340415
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04340747
7
04342737
7
04350633
9
04351846
7
04355105
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04395414
8
04396772
7
04401808
8
04453013
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04454291
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04454292
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04461896
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04477369
7
04533660
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04536402
7
04549019
10
04565882
8
04611002
7
04613463
35
04621078
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04657700
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04690936
10
04692458
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04711895
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04734420
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04736057
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04745124
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04751018
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04760161
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04764512
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04778790
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04788010
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04831153
7
04889859
9
04894458
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04931568
7
04954278
7
04954328
8
05112863
7
05232624
7
05401621
7
06071927
10
06110491
7
06528526
7
07932007
7
07932354
7

Sample Use Guides

In Vivo Use Guide
Split-Dose (2-Day) Regimen: The evening before colonoscopy: dilute one bottle with water to a total volume of 16 oz. (up to the fill line) and drink the entire amount. Drink 32 ounces of water over the next hour. Next morning: repeat both steps using the second bottle. Complete preparation at least 2 hours before colonoscopy or as directed by a physician.
Route of Administration: Oral
Name Type Language
Sulfuric acid
EP   FCC   HSDB   II   INCI   MART.   MI   VANDF   WHO-DD  
INCI  
Official Name English
INS-513
Code English
SULFURIC ACID [II]
Common Name English
ANHYDROUS SULFURIC ACID
Common Name English
SULFURIC ACID [FCC]
Common Name English
SULFURIC ACID [EP MONOGRAPH]
Common Name English
SULFURIC ACID [MI]
Common Name English
SULPHURICUM ACIDUM
HPUS  
Common Name English
E-513
Code English
DIHYDROGEN SULPHATE
Systematic Name English
SULFURIC ACID [MART.]
Common Name English
DIHYDROGEN SULFATE
Systematic Name English
NSC-248648
Code English
SULFURIC ACID [INCI]
Common Name English
SULFURIC ACID [VANDF]
Common Name English
NSC-38965
Code English
SULFURIC ACID [EP IMPURITY]
Common Name English
INS NO.513
Code English
SULPHURIC ACID
Systematic Name English
TETRAOXOSULFURIC ACID
Common Name English
SULPHURICUM ACIDUM [HPUS]
Common Name English
BRIMSTONE ACID
Common Name English
Sulfuric acid [WHO-DD]
Common Name English
Classification Tree Code System Code
CODEX ALIMENTARIUS (GSFA) INS-513
Created by admin on Fri Dec 15 15:58:25 GMT 2023 , Edited by admin on Fri Dec 15 15:58:25 GMT 2023
Food Contact Sustance Notif, (FCN No.) FCN NO. 908
Created by admin on Fri Dec 15 15:58:25 GMT 2023 , Edited by admin on Fri Dec 15 15:58:25 GMT 2023
Food Contact Sustance Notif, (FCN No.) FCN NO. 887
Created by admin on Fri Dec 15 15:58:25 GMT 2023 , Edited by admin on Fri Dec 15 15:58:25 GMT 2023
EPA PESTICIDE CODE 78001
Created by admin on Fri Dec 15 15:58:25 GMT 2023 , Edited by admin on Fri Dec 15 15:58:25 GMT 2023
DEA NO. 6552
Created by admin on Fri Dec 15 15:58:25 GMT 2023 , Edited by admin on Fri Dec 15 15:58:25 GMT 2023
Food Contact Sustance Notif, (FCN No.) FCN NO. 879
Created by admin on Fri Dec 15 15:58:25 GMT 2023 , Edited by admin on Fri Dec 15 15:58:25 GMT 2023
Food Contact Sustance Notif, (FCN No.) FCN NO. 951
Created by admin on Fri Dec 15 15:58:25 GMT 2023 , Edited by admin on Fri Dec 15 15:58:25 GMT 2023
JECFA EVALUATION INS-513
Created by admin on Fri Dec 15 15:58:25 GMT 2023 , Edited by admin on Fri Dec 15 15:58:25 GMT 2023
Food Contact Sustance Notif, (FCN No.) FCN NO. 1093
Created by admin on Fri Dec 15 15:58:25 GMT 2023 , Edited by admin on Fri Dec 15 15:58:25 GMT 2023
Food Contact Sustance Notif, (FCN No.) FCN NO. 1094
Created by admin on Fri Dec 15 15:58:25 GMT 2023 , Edited by admin on Fri Dec 15 15:58:25 GMT 2023
CFR 21 CFR 184.1095
Created by admin on Fri Dec 15 15:58:25 GMT 2023 , Edited by admin on Fri Dec 15 15:58:25 GMT 2023
Food Contact Sustance Notif, (FCN No.) FCN NO. 447
Created by admin on Fri Dec 15 15:58:25 GMT 2023 , Edited by admin on Fri Dec 15 15:58:25 GMT 2023
Food Contact Sustance Notif, (FCN No.) FCN NO. 1132
Created by admin on Fri Dec 15 15:58:25 GMT 2023 , Edited by admin on Fri Dec 15 15:58:25 GMT 2023
Code System Code Type Description
CAS
7664-93-9
Created by admin on Fri Dec 15 15:58:24 GMT 2023 , Edited by admin on Fri Dec 15 15:58:24 GMT 2023
PRIMARY
ALANWOOD
sulfuric acid
Created by admin on Fri Dec 15 15:58:25 GMT 2023 , Edited by admin on Fri Dec 15 15:58:25 GMT 2023
PRIMARY
CHEBI
26836
Created by admin on Fri Dec 15 15:58:25 GMT 2023 , Edited by admin on Fri Dec 15 15:58:25 GMT 2023
PRIMARY
EVMPD
SUB179543
Created by admin on Fri Dec 15 15:58:25 GMT 2023 , Edited by admin on Fri Dec 15 15:58:25 GMT 2023
PRIMARY
PUBCHEM
1118
Created by admin on Fri Dec 15 15:58:25 GMT 2023 , Edited by admin on Fri Dec 15 15:58:25 GMT 2023
PRIMARY
NSC
38965
Created by admin on Fri Dec 15 15:58:25 GMT 2023 , Edited by admin on Fri Dec 15 15:58:25 GMT 2023
PRIMARY
NCI_THESAURUS
C28191
Created by admin on Fri Dec 15 15:58:25 GMT 2023 , Edited by admin on Fri Dec 15 15:58:25 GMT 2023
PRIMARY
EPA CompTox
DTXSID5029683
Created by admin on Fri Dec 15 15:58:25 GMT 2023 , Edited by admin on Fri Dec 15 15:58:25 GMT 2023
PRIMARY
ECHA (EC/EINECS)
231-639-5
Created by admin on Fri Dec 15 15:58:25 GMT 2023 , Edited by admin on Fri Dec 15 15:58:25 GMT 2023
PRIMARY
WIKIPEDIA
SULFURIC ACID
Created by admin on Fri Dec 15 15:58:25 GMT 2023 , Edited by admin on Fri Dec 15 15:58:25 GMT 2023
PRIMARY
EVMPD
SUB45925
Created by admin on Fri Dec 15 15:58:24 GMT 2023 , Edited by admin on Fri Dec 15 15:58:24 GMT 2023
PRIMARY
NSC
248648
Created by admin on Fri Dec 15 15:58:25 GMT 2023 , Edited by admin on Fri Dec 15 15:58:25 GMT 2023
PRIMARY
NCI_THESAURUS
C45678
Created by admin on Fri Dec 15 15:58:25 GMT 2023 , Edited by admin on Fri Dec 15 15:58:25 GMT 2023
CONCEPT Industrial Aid
FDA UNII
O40UQP6WCF
Created by admin on Fri Dec 15 15:58:25 GMT 2023 , Edited by admin on Fri Dec 15 15:58:25 GMT 2023
PRIMARY
DAILYMED
O40UQP6WCF
Created by admin on Fri Dec 15 15:58:25 GMT 2023 , Edited by admin on Fri Dec 15 15:58:25 GMT 2023
PRIMARY
SMS_ID
100000131607
Created by admin on Fri Dec 15 15:58:25 GMT 2023 , Edited by admin on Fri Dec 15 15:58:25 GMT 2023
PRIMARY
HSDB
1811
Created by admin on Fri Dec 15 15:58:25 GMT 2023 , Edited by admin on Fri Dec 15 15:58:25 GMT 2023
PRIMARY
DRUG BANK
DB11309
Created by admin on Fri Dec 15 15:58:25 GMT 2023 , Edited by admin on Fri Dec 15 15:58:25 GMT 2023
PRIMARY
MERCK INDEX
m10374
Created by admin on Fri Dec 15 15:58:25 GMT 2023 , Edited by admin on Fri Dec 15 15:58:25 GMT 2023
PRIMARY Merck Index
RXCUI
10231
Created by admin on Fri Dec 15 15:58:25 GMT 2023 , Edited by admin on Fri Dec 15 15:58:25 GMT 2023
PRIMARY RxNorm
ChEMBL
CHEMBL572964
Created by admin on Fri Dec 15 15:58:25 GMT 2023 , Edited by admin on Fri Dec 15 15:58:25 GMT 2023
PRIMARY
MESH
C033158
Created by admin on Fri Dec 15 15:58:25 GMT 2023 , Edited by admin on Fri Dec 15 15:58:25 GMT 2023
PRIMARY
ACTIVE MOIETY
Structure of Sulfuric acid
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