LOSULAZINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C27H22F4N4O3S
Molecular Weight	558.547
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

FC1=CC=C(C=C1)S(=O)(=O)N2CCN(CC2)C(=O)C3=CC=C(NC4=C5C=CC(=CC5=NC=C4)C(F)(F)F)C=C3

InChI

InChIKey=SYJKIRZBDWNJSB-UHFFFAOYSA-N

InChI=1S/C27H22F4N4O3S/c28-20-4-8-22(9-5-20)39(37,38)35-15-13-34(14-16-35)26(36)18-1-6-21(7-2-18)33-24-11-12-32-25-17-19(27(29,30)31)3-10-23(24)25/h1-12,17H,13-16H2,(H,32,33)

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6822289 | https://www.ncbi.nlm.nih.gov/pubmed/3941407 | https://www.ncbi.nlm.nih.gov/pubmed/4017421

Losulazine (U-54,669F) is an antihypertensive agent acting by a sympatholytic mechanism. It appears to alter peripheral sympathetic neurogenic function but apparently does not enter the central nervous system. Losulazine effectively lowered the blood pressure in patients with hypertension.

Originator

Approval Year

PubMed

Title	Date	PubMed
Study on the activities of testes and accessory sex glands after losulazine treatment in rats.	1994-09	8091426
Comparison of the effects of losulazine and reserpine on central aminergic neurons.	1993-11	8236258
Mechanism of anestrus in rats treated with an antihypertensive agent, losulazine hydrochloride.	1987-01	3099429
7-(Trifluoromethyl)-4-aminoquinoline hypotensives: novel peripheral sympatholytics.	1986-01	3941407
Losulazine, a new antihypertensive.	1985-08	4017421

Patents

Name

Type

Language

1-((P-FLUOROPHENYL)SULFONYL)-4-(P-((7-(TRIFLUOROMETHYL)-4-QUINOLYL)AMINO)BENZOYL)PIPERAZINE

Preferred Name

English

LOSULAZINE

Official Name

English

losulazine [INN]

Common Name

English

Code System Code Type Description

CAS

72141-57-2