Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C49H76N6O11 |
Molecular Weight | 925.1613 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 9 / 9 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@]1(CCCN1C(=O)C[C@@H](OC)[C@H]([C@@H](C)CC)N(C)C(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)C(=O)CCCCCN2C(=O)C=CC2=O)C(C)C)[C@H](OC)[C@@H](C)C(=O)N[C@@H](CC3=CC=CC=C3)C(O)=O
InChI
InChIKey=ORFNVPGICPYLJV-YTVPMEHESA-N
InChI=1S/C49H76N6O11/c1-12-32(6)44(37(65-10)29-41(59)54-27-19-22-36(54)45(66-11)33(7)46(60)50-35(49(63)64)28-34-20-15-13-16-21-34)53(9)48(62)42(30(2)3)51-47(61)43(31(4)5)52(8)38(56)23-17-14-18-26-55-39(57)24-25-40(55)58/h13,15-16,20-21,24-25,30-33,35-37,42-45H,12,14,17-19,22-23,26-29H2,1-11H3,(H,50,60)(H,51,61)(H,63,64)/t32-,33+,35-,36-,37+,42-,43-,44-,45+/m0/s1
Mafodotin (mc-MMAF) is a hydrophilic non-cleavable antimicrotubule and antimitotic agent, monomethyl auristatin F (MMAF) derivative, having a maleimidocaproyl linker (mc linker), which is ready to conjugate to an antibody or other proteins or biopolymers. Antibody-drug conjugates having mafodotin such as Depatuxizumab mafodotin and Belantamab mafodotin have undergone clinical trials for the treatment of neoplasms.
Approval Year
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O19V2N6W9T
Created by
admin on Sat Dec 16 01:30:33 GMT 2023 , Edited by admin on Sat Dec 16 01:30:33 GMT 2023
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DTXSID90235521
Created by
admin on Sat Dec 16 01:30:33 GMT 2023 , Edited by admin on Sat Dec 16 01:30:33 GMT 2023
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863971-19-1
Created by
admin on Sat Dec 16 01:30:33 GMT 2023 , Edited by admin on Sat Dec 16 01:30:33 GMT 2023
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YY-55
Created by
admin on Sat Dec 16 01:30:33 GMT 2023 , Edited by admin on Sat Dec 16 01:30:33 GMT 2023
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300000011361
Created by
admin on Sat Dec 16 01:30:33 GMT 2023 , Edited by admin on Sat Dec 16 01:30:33 GMT 2023
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56949327
Created by
admin on Sat Dec 16 01:30:33 GMT 2023 , Edited by admin on Sat Dec 16 01:30:33 GMT 2023
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CHEMBL2107813
Created by
admin on Sat Dec 16 01:30:33 GMT 2023 , Edited by admin on Sat Dec 16 01:30:33 GMT 2023
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C174776
Created by
admin on Sat Dec 16 01:30:33 GMT 2023 , Edited by admin on Sat Dec 16 01:30:33 GMT 2023
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SUBSTANCE RECORD