TIOXIDAZOLE

Possibly Marketed Outside US

Details

Stereochemistry	ACHIRAL
Molecular Formula	C12H14N2O3S
Molecular Weight	266.316
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCCOC1=CC2=C(C=C1)N=C(NC(=O)OC)S2

InChI

InChIKey=HLLICFJUWSZHRJ-UHFFFAOYSA-N

InChI=1S/C12H14N2O3S/c1-3-6-17-8-4-5-9-10(7-8)18-11(13-9)14-12(15)16-2/h4-5,7H,3,6H2,1-2H3,(H,13,14,15)

HIDE SMILES / InChI

Description
Sources: https://www.drugs.com/international/tioxidazole.html | https://www.ncbi.nlm.nih.gov/pubmed/658283

Ttioxidazole has broad spectrum activity against gastrointestinal nematodes. Tiox (tioxidazole) Paste is indicated for removal of mature large strongyles (Strongylus edentatus, S.equinus , and S.vulgaris ), mature ascarids (Parascaris equorum and immature (4th larval stage) pinworms (Oxyuris equi), and mature small strongyles (Triodontophorus spp). Ttioxidazole is a tubulin polymerization inhibitor.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Strongylus vulgaris 1 Target ID: Strongylus vulgaris Sources: https://www.ncbi.nlm.nih.gov/pubmed/7283235 \| https://www.fda.gov/downloads/AnimalVeterinary/Products/ApprovedAnimalDrugProducts/FOIADrugSummaries/UCM472692.pdf	Inhibitor 8504
Parascaris equorum 1 Target ID: Parascaris equorum Sources: https://www.ncbi.nlm.nih.gov/pubmed/7283235 \| https://www.fda.gov/downloads/AnimalVeterinary/Products/ApprovedAnimalDrugProducts/FOIADrugSummaries/UCM472692.pdf	Inhibitor 8504
microtubule polymerization 21 Target ID: GO:0046785 Sources: http://en.chembase.cn/substance-449448.html \| https://www.ncbi.nlm.nih.gov/pubmed/25267663	Inhibitor 8504

Conditions

Condition	Modality	Targets	Highest Phase	Product
Helminthiasis 39 Sources: https://www.ncbi.nlm.nih.gov/pubmed/7283235 https://www.ncbi.nlm.nih.gov/pubmed/7447131 https://www.ncbi.nlm.nih.gov/pubmed/658283	Curative		Approved 8583	Tiox Approved Use Tiox (tioxidazole) Paste is indicated for removal of mature large strongyles (Strongylus edentatus, S.equinus , and S.vulgaris ), mature ascarids (Parascaris equorum and immature (4th larval stage) pinworms (Oxyuris equi), and mature small strongyles (Triodontophorus spp). Launch Date 1987

PubMed

Title	Date	PubMed
Discovery of novel antigiardiasis drug candidates.	2014-12	25267663
Structure-activity relationships of benzothiazole and benzimidazole anthelmintics: a molecular modeling approach to in vivo drug efficacy.	1990-12	2254820

Patents

Sample Use Guides

In Vivo Use Guide

Horses: 5 mg of tioxidazole per pound of body weight as a single dose.

Route of Administration: Oral

In Vitro Use Guide

Tioxidazole inhibited G. lamblia WT strain with IC50= 0.97 uM.

Name

Type

Language

SCH-21480

Preferred Name

English

TIOXIDAZOLE

Official Name

English

Methyl 6-propoxy-2-benzothiazolecarbamate

Common Name

English

SCH 21480

Code

English

TIOXIDAZOLE [MI]

Common Name

English

tioxidazole [INN]

Common Name

English

CARBAMIC ACID, (6-PROPOXY-2-BENZOTHIAZOLYL)-, METHYL ESTER

Common Name

English

TIOXIDAZOLE [USAN]

Common Name

English

TIOXIDAZOLE [GREEN BOOK]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C250