TIOXIDAZOLE

Possibly Marketed Outside US

Details

Stereochemistry	ACHIRAL
Molecular Formula	C12H14N2O3S
Molecular Weight	266.316
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCCOC1=CC=C2N=C(NC(=O)OC)SC2=C1

InChI

InChIKey=HLLICFJUWSZHRJ-UHFFFAOYSA-N

InChI=1S/C12H14N2O3S/c1-3-6-17-8-4-5-9-10(7-8)18-11(13-9)14-12(15)16-2/h4-5,7H,3,6H2,1-2H3,(H,13,14,15)

HIDE SMILES / InChI

Description
Sources: https://www.drugs.com/international/tioxidazole.html | https://www.ncbi.nlm.nih.gov/pubmed/658283

Ttioxidazole has broad spectrum activity against gastrointestinal nematodes. Tiox (tioxidazole) Paste is indicated for removal of mature large strongyles (Strongylus edentatus, S.equinus , and S.vulgaris ), mature ascarids (Parascaris equorum and immature (4th larval stage) pinworms (Oxyuris equi), and mature small strongyles (Triodontophorus spp). Ttioxidazole is a tubulin polymerization inhibitor.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Strongylus vulgaris 1 Target ID: Strongylus vulgaris Sources: https://www.ncbi.nlm.nih.gov/pubmed/7283235 \| https://www.fda.gov/downloads/AnimalVeterinary/Products/ApprovedAnimalDrugProducts/FOIADrugSummaries/UCM472692.pdf	Inhibitor 8297
Parascaris equorum 1 Target ID: Parascaris equorum Sources: https://www.ncbi.nlm.nih.gov/pubmed/7283235 \| https://www.fda.gov/downloads/AnimalVeterinary/Products/ApprovedAnimalDrugProducts/FOIADrugSummaries/UCM472692.pdf	Inhibitor 8297
microtubule polymerization 20 Target ID: GO:0046785 Sources: http://en.chembase.cn/substance-449448.html \| https://www.ncbi.nlm.nih.gov/pubmed/25267663	Inhibitor 8297

Conditions

Condition	Modality	Targets	Highest Phase	Product
Helminthiasis 39 Sources: https://www.ncbi.nlm.nih.gov/pubmed/7283235 https://www.ncbi.nlm.nih.gov/pubmed/7447131 https://www.ncbi.nlm.nih.gov/pubmed/658283	Curative		Approved 8429	Tiox Approved Use Tiox (tioxidazole) Paste is indicated for removal of mature large strongyles (Strongylus edentatus, S.equinus , and S.vulgaris ), mature ascarids (Parascaris equorum and immature (4th larval stage) pinworms (Oxyuris equi), and mature small strongyles (Triodontophorus spp). Launch Date 1987

PubMed

Title	Date	PubMed
Structure-activity relationships of benzothiazole and benzimidazole anthelmintics: a molecular modeling approach to in vivo drug efficacy.	1990 Dec	2254820
Discovery of novel antigiardiasis drug candidates.	2014 Dec	25267663

Patents

Sample Use Guides

In Vivo Use Guide

Horses: 5 mg of tioxidazole per pound of body weight as a single dose.

Route of Administration: Oral

In Vitro Use Guide

Tioxidazole inhibited G. lamblia WT strain with IC50= 0.97 uM.

Name

Type

Language

TIOXIDAZOLE

Official Name

English

Methyl 6-propoxy-2-benzothiazolecarbamate

Common Name

English

SCH 21480

Code

English

TIOXIDAZOLE [MI]

Common Name

English

tioxidazole [INN]

Common Name

English

SCH-21480

Code

English

CARBAMIC ACID, (6-PROPOXY-2-BENZOTHIAZOLYL)-, METHYL ESTER

Common Name

English

TIOXIDAZOLE [USAN]

Common Name

English

TIOXIDAZOLE [GREEN BOOK]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C250