Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C14H16O3 |
Molecular Weight | 232.275 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 1 / 1 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
COC1=CC(=O)O[C@@H](CCC2=CC=CC=C2)C1
InChI
InChIKey=VOOYTQRREPYRIW-LBPRGKRZSA-N
InChI=1S/C14H16O3/c1-16-13-9-12(17-14(15)10-13)8-7-11-5-3-2-4-6-11/h2-6,10,12H,7-9H2,1H3/t12-/m0/s1
DescriptionSources: https://www.ncbi.nlm.nih.gov/pubmed/12494336
Sources: https://www.ncbi.nlm.nih.gov/pubmed/12494336
Dihydrokavain (or DIHYDROKAWAIN) is one of the six major kavalactones found in the kava plant. It was shown that dihydrokavain might play an important role in regulation of GABAergic neurotransmission, because this compound can modulate the brainstem GABAergic mechanism.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
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Target ID: GABAergic activity Sources: https://www.ncbi.nlm.nih.gov/pubmed/12494336 |
Conditions
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PubMed
Title | Date | PubMed |
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Interaction of various Piper methysticum cultivars with CNS receptors in vitro. | 2001 Jun |
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Kavalactones and dihydrokavain modulate GABAergic activity in a rat gastric-brainstem preparation. | 2002 Dec |
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Inhibition of cytochrome P450 3A4 by extracts and kavalactones of Piper methysticum (Kava-Kava). | 2002 Dec |
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Determination of six kavalactones in dietary supplements and selected functional foods containing Piper methysticum by isocratic liquid chromatography with internal standard. | 2005 Jan-Feb |
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Extracts and kavalactones of Piper methysticum G. Forst (kava-kava) inhibit P-glycoprotein in vitro. | 2005 Nov |
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Cyclodextrins as carriers for kavalactones in aqueous media: spectroscopic characterization of (S)-7,8-dihydrokavain and beta-cyclodextrin inclusion complex. | 2010 Aug 1 |
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Nutritional and herbal supplements for anxiety and anxiety-related disorders: systematic review. | 2010 Oct 7 |
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Methysticin and 7,8-dihydromethysticin are two major kavalactones in kava extract to induce CYP1A1. | 2011 Dec |
Sample Use Guides
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/12494336
Pretreatment with dihydrokavain (300 uM) significantly decreased the nucleus tractus solitarius (NTS) inhibitory effects induced by muscimol (30 uM), approximately from 51 % to 36 %. Dihydrokavain induced inhibitory effects was not reduced after co-application of saclofen or naloxone.
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DSLD |
2592 (Number of products:13)
Created by
admin on Sat Dec 16 08:51:37 GMT 2023 , Edited by admin on Sat Dec 16 08:51:37 GMT 2023
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DIHYDROKAVAIN
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112163
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587-63-3
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m6605
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NW8ZGW9XRZ
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10220256
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DTXSID8033433
Created by
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SUBSTANCE RECORD