Details
Stereochemistry | RACEMIC |
Molecular Formula | C4H8O5 |
Molecular Weight | 136.1033 |
Optical Activity | ( + / - ) |
Defined Stereocenters | 2 / 2 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
OC[C@@H](O)[C@H](O)C(O)=O
InChI
InChIKey=JPIJQSOTBSSVTP-GBXIJSLDSA-N
InChI=1S/C4H8O5/c5-1-2(6)3(7)4(8)9/h2-3,5-7H,1H2,(H,8,9)/t2-,3+/m1/s1
DescriptionSources: https://www.ncbi.nlm.nih.gov/pubmed/28306698 | https://www.cancer.gov/publications/dictionaries/cancer-drug/def/magnesium-l-threonate | https://www.ncbi.nlm.nih.gov/pubmed/30829204https://www.ncbi.nlm.nih.gov/pubmed/6684626 | https://www.ncbi.nlm.nih.gov/pubmed/10420182 | http://www.hmdb.ca/metabolites/HMDB0000943
Sources: https://www.ncbi.nlm.nih.gov/pubmed/28306698 | https://www.cancer.gov/publications/dictionaries/cancer-drug/def/magnesium-l-threonate | https://www.ncbi.nlm.nih.gov/pubmed/30829204https://www.ncbi.nlm.nih.gov/pubmed/6684626 | https://www.ncbi.nlm.nih.gov/pubmed/10420182 | http://www.hmdb.ca/metabolites/HMDB0000943
Sodium threonate (threonic acid) is a major breakdown product of ascorbic acid used as a food additive. It is formed in insignificant amounts from ascorbic acid used as a technological aid in the food industry. When administered orally to guinea-pigs (100 mg/kg body weight) for periods of 4 or 28 days, it produced a significant fall in the ascorbic acid concentration of certain organs but was without effect on other physiological and biochemical characteristics. The lifespan of scorbutic guinea-pigs was significantly reduced by dietary threonic acid (100 mg/kg body weight). The results indicate that threonic acid may modify the metabolism of ascorbic acid in guinea-pigs. Threonic acid is a normal component is aqeous humour and blood. Threonic acid is a substrate of L-threonate 3-dehydrogenase in ascorbate and aldarate metabolism pathway.
Approval Year
PubMed
Title | Date | PubMed |
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Sugars including erythronic and threonic acids in human aqueous humour. | 1999 Aug |
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Evaluation of a sunscreen photoprotective effect by ascorbic acid assessment in human dermis using microdialysis and gas chromatography mass spectrometry. | 2005 Mar |
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Chronic dietary magnesium-L-threonate speeds extinction and reduces spontaneous recovery of a conditioned taste aversion. | 2013 May |
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Magnesium L-threonate prevents and restores memory deficits associated with neuropathic pain by inhibition of TNF-α. | 2013 Sep-Oct |
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Oral Application of Magnesium-L-Threonate Attenuates Vincristine-induced Allodynia and Hyperalgesia by Normalization of Tumor Necrosis Factor-α/Nuclear Factor-κB Signaling. | 2017 Jun |
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Distinct metabolomic signature in cerebrospinal fluid in early parkinson's disease. | 2017 Oct |
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Defective methionine metabolism in the brain after repeated blast exposures might contribute to increased oxidative stress. | 2018 Jan |
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Neurobehavioral and biochemical effects of magnesium chloride (MgCl2), magnesium sulphate (MgSO4) and magnesium-L-threonate (MgT) supplementation in rats: A dose dependent comparative study. | 2019 Jan |
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DSLD |
3535 (Number of products:6)
Created by
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100000137469
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NTD0MI8XRT
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26984
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THREONIC ACID
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1547557
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151152
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DTXSID40192337
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SUB75725
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NTD0MI8XRT
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3909-12-4
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DB14228
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ACTIVE MOIETY
SALT/SOLVATE (PARENT)