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Details

Stereochemistry ABSOLUTE
Molecular Formula C18H23FINO2
Molecular Weight 430.2861
Optical Activity UNSPECIFIED
Defined Stereocenters 4 / 4
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of IOFLUPANE F-18

SMILES

[H][C@]12CC[C@]([H])([C@H]([C@H](C1)C3=CC=C(I)C=C3)C(=O)OC)N2CCC[18F]

InChI

InChIKey=HXWLAJVUJSVENX-LNYNZGDVSA-N
InChI=1S/C18H23FINO2/c1-23-18(22)17-15(12-3-5-13(20)6-4-12)11-14-7-8-16(17)21(14)10-2-9-19/h3-6,14-17H,2,7-11H2,1H3/t14-,15+,16+,17-/m0/s1/i19-1

HIDE SMILES / InChI

Description

18F-beta-CIT-FP is a cocaine analog with high affinity for the dopamine transporter. The compound is used as an imaging agent for PET studies and was approved in Korea to diagnose Parkinson's disease.

CNS Activity

Approval Year

Unknown
139594
Targets

Targets

Primary TargetPharmacologyConditionPotency
Binding Agent
1064
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Diagnostic
Approved
8429
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Radiosynthesis of [18F] N-3-fluoropropyl-2-beta-carbomethoxy-3-beta-(4-iodophenyl) nortropane and the first human study with positron emission tomography.
1996 Nov
[18F] beta-CIT-FP is superior to [11C] beta-CIT-FP for quantitation of the dopamine transporter.
1997 Oct

Sample Use Guides

In Vivo Use Guide
18F-beta-CIT-FP is administered instravenously at 5mCi 90 min before PET procedure
Route of Administration: Intravenous
Name Type Language
IOFLUPANE F-18
Common Name English
18FLUORINE-N-3-FLUOROPROPYL-2BETA-CARBOMETHOXY-3BETA-(4-IODOPHENYL) NORTROPANE
Common Name English
8-AZABICYCLO(3.2.1)OCTANE-2-CARBOXYLIC ACID, 8-(3-(FLUORO-18F)PROPYL)-3-(4-IODOPHENYL)-, METHYL ESTER, (1R,2S,3S,5S)-
Systematic Name English
18F-FP-.BETA.-CIT
Common Name English
(18F)FP-CIT
Common Name English
METHYL (1S,3S,4S,5R)-8-(3-FLUORANYLPROPYL)-3-(4-IODOPHENYL)-8-AZABICYCLO(3.2.1)OCTANE-4-CARBOXYLATE
Systematic Name English
18F-FPCIT
Common Name English
F-18-FPCIT
Common Name English
18F-IOFLUPANE
Common Name English
18F-BETA-CIT-FP
Common Name English
FP-CIT F-18
Common Name English
18F-CIT-FP
Common Name English
Classification Tree Code System Code
FDA ORPHAN DRUG 451114
Created by admin on Sat Dec 16 11:34:57 GMT 2023 , Edited by admin on Sat Dec 16 11:34:57 GMT 2023
Code System Code Type Description
FDA UNII
NT4P0L3OCX
Created by admin on Sat Dec 16 11:34:57 GMT 2023 , Edited by admin on Sat Dec 16 11:34:57 GMT 2023
PRIMARY
CAS
186381-69-1
Created by admin on Sat Dec 16 11:34:57 GMT 2023 , Edited by admin on Sat Dec 16 11:34:57 GMT 2023
PRIMARY
PUBCHEM
11626128
Created by admin on Sat Dec 16 11:34:57 GMT 2023 , Edited by admin on Sat Dec 16 11:34:57 GMT 2023
PRIMARY
ACTIVE MOIETY
Structure of IOFLUPANE F-18
NIH
NCATS
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