U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C13H14N6O2
Molecular Weight 286.2893
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of METAZIDE

SMILES

O=C(NNCNNC(=O)C1=CC=NC=C1)C2=CC=NC=C2

InChI

InChIKey=WWCIFIOLOMCRET-UHFFFAOYSA-N
InChI=1S/C13H14N6O2/c20-12(10-1-5-14-6-2-10)18-16-9-17-19-13(21)11-3-7-15-8-4-11/h1-8,16-17H,9H2,(H,18,20)(H,19,21)

HIDE SMILES / InChI
Metazide (RO 2-4969), a isonicotinic acid hydrazide derivative, is a tuberculostatic agent. Metazid causes damage to the membrane of Mycobacterium tuberculosis, inhibits metabolic and oxidative processes, inhibits the synthesis of nucleic acids, inhibiting the proliferation of bacteria inside and outside the cell. It has been used in the treatment of all forms and localizations of active tuberculosis in adults and children

Approval Year

PubMed

PubMed

TitleDatePubMed
Preliminary observations on a new derivative of isoniazid (Ro 2-4969).
1953 Nov
Medical treatment of tuberculosis: a study of RO 2-4969 in the treatment of tuberculosis.
1954
[Metazid tablets].
1960

Sample Use Guides

Adults - 500 mg 2 times / day. The maximum single dose - 1 g daily - 2 g. Children - at a dose of 20-30 mg / kg / day. The maximum daily dose is 1 g. The daily dose should be divided into 2-3 doses.
Route of Administration: Oral
Name Type Language
METAZIDE
INN  
INN  
Official Name English
Metazide [WHO-DD]
Common Name English
ISONICOTINIC ACID 2,2'-METHYLENEDIHYDRAZIDE
Common Name English
NSC-39302
Code English
metazide [INN]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C47795
Created by admin on Fri Dec 15 15:31:38 GMT 2023 , Edited by admin on Fri Dec 15 15:31:38 GMT 2023
Code System Code Type Description
NCI_THESAURUS
C66108
Created by admin on Fri Dec 15 15:31:38 GMT 2023 , Edited by admin on Fri Dec 15 15:31:38 GMT 2023
PRIMARY
NSC
39302
Created by admin on Fri Dec 15 15:31:38 GMT 2023 , Edited by admin on Fri Dec 15 15:31:38 GMT 2023
PRIMARY
ChEMBL
CHEMBL1526558
Created by admin on Fri Dec 15 15:31:38 GMT 2023 , Edited by admin on Fri Dec 15 15:31:38 GMT 2023
PRIMARY
PUBCHEM
15568
Created by admin on Fri Dec 15 15:31:38 GMT 2023 , Edited by admin on Fri Dec 15 15:31:38 GMT 2023
PRIMARY
FDA UNII
NSL1M7IFYP
Created by admin on Fri Dec 15 15:31:38 GMT 2023 , Edited by admin on Fri Dec 15 15:31:38 GMT 2023
PRIMARY
CAS
1707-15-9
Created by admin on Fri Dec 15 15:31:38 GMT 2023 , Edited by admin on Fri Dec 15 15:31:38 GMT 2023
PRIMARY
INN
3085
Created by admin on Fri Dec 15 15:31:38 GMT 2023 , Edited by admin on Fri Dec 15 15:31:38 GMT 2023
PRIMARY
EVMPD
SUB08819MIG
Created by admin on Fri Dec 15 15:31:38 GMT 2023 , Edited by admin on Fri Dec 15 15:31:38 GMT 2023
PRIMARY
SMS_ID
100000081200
Created by admin on Fri Dec 15 15:31:38 GMT 2023 , Edited by admin on Fri Dec 15 15:31:38 GMT 2023
PRIMARY
EPA CompTox
DTXSID9046239
Created by admin on Fri Dec 15 15:31:38 GMT 2023 , Edited by admin on Fri Dec 15 15:31:38 GMT 2023
PRIMARY