Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C27H32N2O6S2 |
| Molecular Weight | 544.683 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCN(CC)C1=CC=C(C=C1)C(=C2C=CC(C=C2)=[N+](CC)CC)C3=C(C=CC(=C3)S(O)(=O)=O)S([O-])(=O)=O
InChI
InChIKey=YFKDCGWIINMRQY-UHFFFAOYSA-N
InChI=1S/C27H32N2O6S2/c1-5-28(6-2)22-13-9-20(10-14-22)27(21-11-15-23(16-12-21)29(7-3)8-4)25-19-24(36(30,31)32)17-18-26(25)37(33,34)35/h9-19H,5-8H2,1-4H3,(H-,30,31,32,33,34,35)
Isosulfan Blue is a synthetic visual lymphatic imaging agent. Injected into the periphery of the tumor site, isosulfan blue localizes to the lymphatic system and aids in the surgical identification of tumor sentinel nodes which stain blue. The chemical name of isosulfan blue is N-[4-[[4-(diethylamino)phenyl] (2,5-disulfophenyl) methylene]-2,5-cyclohexadien-1-ylidene]-N-ethylethanaminium hydroxide, inner salt, sodium salt. Isosulfan blue is a greenish blue color hygroscopic powder. Isosulfan blue injection 1% is a contrast agent for the delineation of lymphatic vessels. Isosulfan blue injection 1% upon subcutaneous administration, delineates lymphatic vessels draining the region of injection. It is an adjunct to lymphography in: primary and secondary lymphedema of the extremities; chyluria, chylous ascites or chylothorax; lymph node involvement by primary or secondary neoplasm; and lymph node response to therapeutic modalities.
Approval Year
Cmax
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
11.03 mg/kg EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/29141490/ |
938 mmol/kg single, subcutaneous dose: 938 mmol/kg route of administration: Subcutaneous experiment type: SINGLE co-administered: |
ISOSULFAN BLUE plasma | Mus musculus population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED |
AUC
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
2.9 mg × h/kg EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/29141490/ |
938 mmol/kg single, subcutaneous dose: 938 mmol/kg route of administration: Subcutaneous experiment type: SINGLE co-administered: |
ISOSULFAN BLUE plasma | Mus musculus population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED |
T1/2
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
0.14 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/29141490/ |
938 mmol/kg single, subcutaneous dose: 938 mmol/kg route of administration: Subcutaneous experiment type: SINGLE co-administered: |
ISOSULFAN BLUE plasma | Mus musculus population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED |
Funbound
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
99% |
unknown, subcutaneous |
ISOSULFAN BLUE plasma | Homo sapiens population: UNKNOWN age: UNKNOWN sex: UNKNOWN food status: UNKNOWN |
Doses
| Dose | Population | Adverse events |
|---|---|---|
3 mL single, subcutaneous (max) Studied dose Dose: 3 mL Route: subcutaneous Route: single Dose: 3 mL Sources: |
unhealthy Health Status: unhealthy Condition: lymphedema of the extremities Sources: |
Other AEs: Hypersensitivity, Respiratory distress... Other AEs: Hypersensitivity (2%) Sources: Respiratory distress (grade 4) Shock (grade 4) Angioedema (grade 4) Urticaria (grade 4) Pruritus (grade 4) |
AEs
| AE | Significance | Dose | Population |
|---|---|---|---|
| Hypersensitivity | 2% | 3 mL single, subcutaneous (max) Studied dose Dose: 3 mL Route: subcutaneous Route: single Dose: 3 mL Sources: |
unhealthy Health Status: unhealthy Condition: lymphedema of the extremities Sources: |
| Angioedema | grade 4 | 3 mL single, subcutaneous (max) Studied dose Dose: 3 mL Route: subcutaneous Route: single Dose: 3 mL Sources: |
unhealthy Health Status: unhealthy Condition: lymphedema of the extremities Sources: |
| Pruritus | grade 4 | 3 mL single, subcutaneous (max) Studied dose Dose: 3 mL Route: subcutaneous Route: single Dose: 3 mL Sources: |
unhealthy Health Status: unhealthy Condition: lymphedema of the extremities Sources: |
| Respiratory distress | grade 4 | 3 mL single, subcutaneous (max) Studied dose Dose: 3 mL Route: subcutaneous Route: single Dose: 3 mL Sources: |
unhealthy Health Status: unhealthy Condition: lymphedema of the extremities Sources: |
| Shock | grade 4 | 3 mL single, subcutaneous (max) Studied dose Dose: 3 mL Route: subcutaneous Route: single Dose: 3 mL Sources: |
unhealthy Health Status: unhealthy Condition: lymphedema of the extremities Sources: |
| Urticaria | grade 4 | 3 mL single, subcutaneous (max) Studied dose Dose: 3 mL Route: subcutaneous Route: single Dose: 3 mL Sources: |
unhealthy Health Status: unhealthy Condition: lymphedema of the extremities Sources: |
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748080-29-7
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DTXSID70225783
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1546453
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NS6Q291771
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NS6Q291771
Created by
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52946590
Created by
admin on Fri Dec 15 21:31:10 GMT 2023 , Edited by admin on Fri Dec 15 21:31:10 GMT 2023
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SUBSTANCE RECORD
