Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C16H13ClN2O.ClH |
Molecular Weight | 321.201 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 1 / 1 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.O[C@]1(N2CCN=C2C3=CC=CC=C13)C4=CC=C(Cl)C=C4
InChI
InChIKey=NIUFFPYONFMTAH-PKLMIRHRSA-N
InChI=1S/C16H13ClN2O.ClH/c17-12-7-5-11(6-8-12)16(20)14-4-2-1-3-13(14)15-18-9-10-19(15)16;/h1-8,20H,9-10H2;1H/t16-;/m1./s1
DescriptionSources: https://www.ncbi.nlm.nih.gov/pubmed/24214825
Sources: https://www.ncbi.nlm.nih.gov/pubmed/24214825
Mazindol was developed as an appetite suppressant. It exists in a dynamic equilibrium between three isomers (the keto and the R and S–ol forms, respectively) with the R or S–ol being the only relevant forms at physiologic pH. Both S- and R-mazindol supposed to target human serotonin and dopamine transporters. R-mazindol is the biologically relevant enantiomer.
CNS Activity
Originator
Sources: https://www.ncbi.nlm.nih.gov/pubmed/804553
Curator's Comment: Originator of R-enantiomer of mazindol is unknown. Mazindol was developed at Sandoz.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL228 Sources: https://www.ncbi.nlm.nih.gov/pubmed/24214825 |
|||
Target ID: CHEMBL238 Sources: https://www.ncbi.nlm.nih.gov/pubmed/24214825 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Name | Type | Language | ||
---|---|---|---|---|
|
Common Name | English | ||
|
Systematic Name | English |
Code System | Code | Type | Description | ||
---|---|---|---|---|---|
|
NLX9ZI72X1
Created by
admin on Sat Dec 16 10:14:01 GMT 2023 , Edited by admin on Sat Dec 16 10:14:01 GMT 2023
|
PRIMARY | |||
|
92135809
Created by
admin on Sat Dec 16 10:14:01 GMT 2023 , Edited by admin on Sat Dec 16 10:14:01 GMT 2023
|
PRIMARY |
SUBSTANCE RECORD