Details
| Stereochemistry | RACEMIC |
| Molecular Formula | C21H25N2S |
| Molecular Weight | 337.502 |
| Optical Activity | ( + / - ) |
| Defined Stereocenters | 0 / 2 |
| E/Z Centers | 0 |
| Charge | 1 |
SHOW SMILES / InChI
SMILES
C[N+]12CCC(CC1)C(CN3C4=C(SC5=C3C=CC=C5)C=CC=C4)C2
InChI
InChIKey=LRHZGVSONLULIX-UHFFFAOYSA-N
InChI=1S/C21H25N2S/c1-23-12-10-16(11-13-23)17(15-23)14-22-18-6-2-4-8-20(18)24-21-9-5-3-7-19(21)22/h2-9,16-17H,10-15H2,1H3/q+1
Mequitamium iodide (LG 30435) is a quaternary ammonium phenothiazine. Mequitamium iodide was found to bind with high affinity only to histamine H1 receptors and to muscarinic acetylcholine receptors. The (+)-(S)-enantiomer is 10-fold more potent than (-)-(R)-enantiomer as a histamine antagonist, while the two enantiomers show the same antimuscarinic activity in vitro. In animal models, it exerts antiasthmatic and antiallergic properties. It was being clinically investigated as a treatment of asthma and rhinitis.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Antihistaminic and antiallergic properties of dextro-mequitamium iodide in upper and lower guinea pig airways: comparison with azelastine. | 1998-04 |
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| Absolute configuration and biological activity of mequitamium iodide enantiomers. | 1994 |
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| Effect of mequitamium iodide (LG 30435) on airway microvascular leakage in the guinea-pig. | 1992-06 |
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| High-affinity binding of mequitamium iodide (LG 30435) to muscarinic and histamine H1 receptors. | 1990-07-17 |
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NID67T2471
Created by
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72029
Created by
admin on Mon Mar 31 21:13:01 GMT 2025 , Edited by admin on Mon Mar 31 21:13:01 GMT 2025
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101396-46-7
Created by
admin on Mon Mar 31 21:13:01 GMT 2025 , Edited by admin on Mon Mar 31 21:13:01 GMT 2025
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ACTIVE MOIETY
SALT/SOLVATE (PARENT)
