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Details

Stereochemistry ACHIRAL
Molecular Formula C22H24ClN3OS2.ClH
Molecular Weight 482.4923
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CLOSPIRAZINE HYDROCHLORIDE

SMILES

c1ccc2c(c1)N(CCCN3CCC4(CC3)N=C(CS4)O)c5cc(ccc5S2)Cl.Cl

InChI

InChIKey=JRSBQVOEILNXGS-UHFFFAOYSA-N
InChI=1S/C22H24ClN3OS2.ClH/c23-16-6-7-20-18(14-16)26(17-4-1-2-5-19(17)29-20)11-3-10-25-12-8-22(9-13-25)24-21(27)15-28-22;/h1-2,4-7,14H,3,8-13,15H2,(H,24,27);1H

HIDE SMILES / InChI
PubMed

PubMed

TitleDatePubMed
[Studies on psychotropic drugs. V. Pharmacological effects of 8-(3-(2-chloro-10-phenothiazinyl)propyl)-1-thia-4,8-diazaspiro(4,5) decan-3-one hydrochloride (APY-606)].
1970 Jul
Correlation between antiavoidance activities of antipsychotic drugs in rats and daily clinical doses.
1981 Feb
High performance liquid chromatography/electrospray tandem mass spectrometry for phenothiazines with heavy side chains in whole blood.
1999
Spiclomazine induces apoptosis associated with the suppression of cell viability, migration and invasion in pancreatic carcinoma cells.
2013
Patents

Sample Use Guides

At the concentration of 50 mg/mL, spiclomazine inhibited cell growth to approximately 69.9 % of the control in HEK-293cells and 46.2 % in HL-7702 cells after treatment for 48h, respectively. The 50% inhibiting concentration (IC50) for 48 h treatment was 31.5 uM for CFPAC-1, 26.8 uM for MIA PaCa-2, 86.9 uM for HEK-293, and 47 uM for HL-7702, respectively.
Name Type Language
CLOSPIRAZINE HYDROCHLORIDE
MI  
Common Name English
8-(3-(2-CHLORO-10-PHENOTHIAZINYL)PROPYL)-3-OXO-1-THIA-4,8-DIAZASPIRO(4,5)DECANE MONOHYDROCHLORIDE
Systematic Name English
APY 606
Code English
CLOSPIRAZINE HYDROCHLORIDE [MI]
Common Name English
DISPERON
Brand Name English
SPICLOMAZINE HYDROCHLORIDE
JAN   WHO-DD  
Common Name English
SPICLOMAZINE HYDROCHLORIDE [JAN]
Common Name English
SPICLOMAZINE HYDROCHLORIDE [WHO-DD]
Common Name English
1-THIA-4,8-DIAZASPIRO(4.5)DECAN-3-ONE, 8-(3-(2-CHLORO-10H-PHENOTHIAZIN-10-YL)PROPYL)-, MONOHYDROCHLORIDE
Common Name English
APY-606
Code English
1-THIA-4,8-DIAZASPIRO(4.5)DECAN-3-ONE, 8-(3-(2-CHLOROPHENOTHIAZIN-10-YL)PROPYL)-, MONOHYDROCHLORIDE
Common Name English
NSC-290956
Code English
DICEPLON
Brand Name English
Code System Code Type Description
PUBCHEM
122820
Created by admin on Sat Jun 26 10:11:38 UTC 2021 , Edited by admin on Sat Jun 26 10:11:38 UTC 2021
PRIMARY
RXCUI
1648692
Created by admin on Sat Jun 26 10:11:38 UTC 2021 , Edited by admin on Sat Jun 26 10:11:38 UTC 2021
PRIMARY RxNorm
MERCK INDEX
M1088
Created by admin on Sat Jun 26 10:11:38 UTC 2021 , Edited by admin on Sat Jun 26 10:11:38 UTC 2021
PRIMARY Merck Index
EPA CompTox
27007-85-8
Created by admin on Sat Jun 26 10:11:38 UTC 2021 , Edited by admin on Sat Jun 26 10:11:38 UTC 2021
PRIMARY
CAS
27007-85-8
Created by admin on Sat Jun 26 10:11:38 UTC 2021 , Edited by admin on Sat Jun 26 10:11:38 UTC 2021
PRIMARY
FDA UNII
N6B142V0U0
Created by admin on Sat Jun 26 10:11:38 UTC 2021 , Edited by admin on Sat Jun 26 10:11:38 UTC 2021
PRIMARY