APREMILAST, (±)-

Details

Stereochemistry	RACEMIC
Molecular Formula	C22H24N2O7S
Molecular Weight	460.5
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCOC1=C(OC)C=CC(=C1)C(CS(C)(=O)=O)N2C(=O)C3=C(C2=O)C(NC(C)=O)=CC=C3

InChI

InChIKey=IMOZEMNVLZVGJZ-UHFFFAOYSA-N

InChI=1S/C22H24N2O7S/c1-5-31-19-11-14(9-10-18(19)30-3)17(12-32(4,28)29)24-21(26)15-7-6-8-16(23-13(2)25)20(15)22(24)27/h6-11,17H,5,12H2,1-4H3,(H,23,25)

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/28213862

APREMILAST, (±)- is a mixture of isomers, one of them is therapeutic active S form (apremilast), an inhibitor of phosphodiesterase 4. This active form is sold under the brand name OTEZLA for the treatment of adult patients with active psoriatic arthritis.

Approval Year

PubMed

Title	Date	PubMed
Apremilast: A Review in Psoriasis and Psoriatic Arthritis.	2017 Mar	28213862

Name

Type

Language

APREMILAST, (±)-

Common Name

English

ACETAMIDE, N-(2-(1-(3-ETHOXY-4-METHOXYPHENYL)-2-(METHYLSULFONYL)ETHYL)-2,3-DIHYDRO-1,3-DIOXO-1H-ISOINDOL-4-YL)-

Systematic Name

English

APREMILAST (±)-FORM [MI]

Common Name

English

Classification Tree Code System Code

FDA ORPHAN DRUG

384812