U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula 2C24H26N4O3S.3H2O.H2O4S
Molecular Weight 1053.231
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of MITAPIVAT SULFATE

SMILES

O.O.O.OS(O)(=O)=O.O=C(N1CCN(CC2CC2)CC1)C3=CC=C(NS(=O)(=O)C4=CC=CC5=C4N=CC=C5)C=C3.O=C(N6CCN(CC7CC7)CC6)C8=CC=C(NS(=O)(=O)C9=CC=CC%10=C9N=CC=C%10)C=C8

InChI

InChIKey=DMRIPASJCJRBMV-UHFFFAOYSA-N
InChI=1S/2C24H26N4O3S.H2O4S.3H2O/c2*29-24(28-15-13-27(14-16-28)17-18-6-7-18)20-8-10-21(11-9-20)26-32(30,31)22-5-1-3-19-4-2-12-25-23(19)22;1-5(2,3)4;;;/h2*1-5,8-12,18,26H,6-7,13-17H2;(H2,1,2,3,4);3*1H2

HIDE SMILES / InChI

Description
Curator's Comment: description was created based on several sources, including http://www.medkoo.com/products/12088

Mitapivat, also known as PKM2 activator 1020, is an activator of a pyruvate kinase PKM2, an enzyme involved in glycolysis. It was disclosed in a patent publication WO 2011002817 A1 as compound 78.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
Activity of PKM2 was measured as changes in absorbance at 350 nm. Reaction mix contained compound, PKM2, ADP, PEP, NADH and LDH prepared in reaction buffer.
Name Type Language
MITAPIVAT SULFATE
USAN  
Official Name English
MITAPIVAT HEMISULFATE SESQUIHYDRATE
Common Name English
PYRUKYND
Brand Name English
AG-348 SULFATE HYDRATE
Code English
8-QUINOLINESULFONAMIDE, N-(4-((4-(CYCLOPROPYLMETHYL)-1-PIPERAZINYL)CARBONYL)PHENYL)-, SULFATE, HYDRATE (2:1:3)
Systematic Name English
N-{4-[4-(Cyclopropylmethyl)piperazine-1-carbonyl]phenyl}quinoline-8-sulfonamide sulfate hydrate (2:1:3)
Systematic Name English
AG-348 HEMISULFATE SESQUIHYDRATE
Code English
MITAPIVAT SULFATE [USAN]
Common Name English
Mitapivat hemisulfate sesquihydrate [WHO-DD]
Common Name English
Classification Tree Code System Code
FDA ORPHAN DRUG 442814
Created by admin on Sat Dec 16 09:59:47 GMT 2023 , Edited by admin on Sat Dec 16 09:59:47 GMT 2023
Code System Code Type Description
SMS_ID
100000183179
Created by admin on Sat Dec 16 09:59:47 GMT 2023 , Edited by admin on Sat Dec 16 09:59:47 GMT 2023
PRIMARY
PUBCHEM
134693700
Created by admin on Sat Dec 16 09:59:47 GMT 2023 , Edited by admin on Sat Dec 16 09:59:47 GMT 2023
PRIMARY
FDA UNII
N4JTA67V3O
Created by admin on Sat Dec 16 09:59:47 GMT 2023 , Edited by admin on Sat Dec 16 09:59:47 GMT 2023
PRIMARY
NCI_THESAURUS
C174739
Created by admin on Sat Dec 16 09:59:47 GMT 2023 , Edited by admin on Sat Dec 16 09:59:47 GMT 2023
PRIMARY
CAS
2151847-10-6
Created by admin on Sat Dec 16 09:59:47 GMT 2023 , Edited by admin on Sat Dec 16 09:59:47 GMT 2023
PRIMARY
EVMPD
SUB197489
Created by admin on Sat Dec 16 09:59:47 GMT 2023 , Edited by admin on Sat Dec 16 09:59:47 GMT 2023
PRIMARY
USAN
FG-159
Created by admin on Sat Dec 16 09:59:47 GMT 2023 , Edited by admin on Sat Dec 16 09:59:47 GMT 2023
PRIMARY
RXCUI
2595574
Created by admin on Sat Dec 16 09:59:47 GMT 2023 , Edited by admin on Sat Dec 16 09:59:47 GMT 2023
PRIMARY