Details
Stereochemistry | ACHIRAL |
Molecular Formula | C19H21N3O5 |
Molecular Weight | 371.3871 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CCOC(=O)C1=C(C)NC(C)=C(C1C2=CC=CC3=NON=C23)C(=O)OCC
InChI
InChIKey=QERUYFVNIOLCHV-UHFFFAOYSA-N
InChI=1S/C19H21N3O5/c1-5-25-18(23)14-10(3)20-11(4)15(19(24)26-6-2)16(14)12-8-7-9-13-17(12)22-27-21-13/h7-9,16,20H,5-6H2,1-4H3
Darodipine is a calcium channel blocking drug, developed by Sandoz in the early 1980s. It potently and selectively antagonizes calcium-induced contraction, decreases the rate of spontaneously beating guinea-pig and rabbit atria. In open-chest dogs, darodipine increased coronary flow and cardiac output, lowered blood pressure, and tended to decrease heart rate while the myocardial contractile force was unchanged. Administration of darodipine led to a significant reduction in mortality and in the severity of neurological symptoms in various types of experimental brain ischemia. Clinical trials demonstrated efficacy for the treatment of stable angina pectoris. In the pilot trial, darodipine was found to be safe but not effective in patients with acute ischemic cerebral infarction.
Approval Year
PubMed
Title | Date | PubMed |
---|---|---|
A comparison of nine calcium ion antagonists and propranolol: exercise tolerance, heart rate and ST-segment changes in patients with chronic stable angina pectoris. | 1987 |
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Aging is associated with increased collagen type IV accumulation in the basal lamina of human cerebral microvessels. | 2004 Sep 24 |
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Exercise as an intervention for the age-related decline in neural metabolic support. | 2010 |
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Brain aging in the oldest-old. | 2010 |
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Angiogenesis in old-aged subjects after ischemic stroke: a cautionary note for investigators. | 2010 Nov 26 |
Patents
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Code System | Code | Type | Description | ||
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C174738
Created by
admin on Sat Dec 16 16:31:29 GMT 2023 , Edited by admin on Sat Dec 16 16:31:29 GMT 2023
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CHEMBL2104154
Created by
admin on Sat Dec 16 16:31:29 GMT 2023 , Edited by admin on Sat Dec 16 16:31:29 GMT 2023
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N4AL7X96GL
Created by
admin on Sat Dec 16 16:31:29 GMT 2023 , Edited by admin on Sat Dec 16 16:31:29 GMT 2023
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SUB06914MIG
Created by
admin on Sat Dec 16 16:31:29 GMT 2023 , Edited by admin on Sat Dec 16 16:31:29 GMT 2023
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X-29
Created by
admin on Sat Dec 16 16:31:29 GMT 2023 , Edited by admin on Sat Dec 16 16:31:29 GMT 2023
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DARODIPINE
Created by
admin on Sat Dec 16 16:31:29 GMT 2023 , Edited by admin on Sat Dec 16 16:31:29 GMT 2023
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DTXSID90223125
Created by
admin on Sat Dec 16 16:31:29 GMT 2023 , Edited by admin on Sat Dec 16 16:31:29 GMT 2023
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C034600
Created by
admin on Sat Dec 16 16:31:29 GMT 2023 , Edited by admin on Sat Dec 16 16:31:29 GMT 2023
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51701
Created by
admin on Sat Dec 16 16:31:29 GMT 2023 , Edited by admin on Sat Dec 16 16:31:29 GMT 2023
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5307
Created by
admin on Sat Dec 16 16:31:29 GMT 2023 , Edited by admin on Sat Dec 16 16:31:29 GMT 2023
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DB09234
Created by
admin on Sat Dec 16 16:31:29 GMT 2023 , Edited by admin on Sat Dec 16 16:31:29 GMT 2023
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100000083443
Created by
admin on Sat Dec 16 16:31:29 GMT 2023 , Edited by admin on Sat Dec 16 16:31:29 GMT 2023
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72803-02-2
Created by
admin on Sat Dec 16 16:31:29 GMT 2023 , Edited by admin on Sat Dec 16 16:31:29 GMT 2023
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PRIMARY |
ACTIVE MOIETY