LENSIPRAZINE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C24H27FN4O2
Molecular Weight	422.4952
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

C[C@H]1OC2=C(NC1=O)C=CC=C2N3CCN(CCCC4=CNC5=C4C=C(F)C=C5)CC3

InChI

InChIKey=SDAMYSWGWHXMRT-MRXNPFEDSA-N

InChI=1S/C24H27FN4O2/c1-16-24(30)27-21-5-2-6-22(23(21)31-16)29-12-10-28(11-13-29)9-3-4-17-15-26-20-8-7-18(25)14-19(17)20/h2,5-8,14-16,26H,3-4,9-13H2,1H3,(H,27,30)/t16-/m1/s1

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Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/18621404 | https://www.medkoo.com/products/8123 | https://www.ncbi.nlm.nih.gov/pubmed/17880057

Lensiprazine (SLV314) is a potent D2 receptor antagonist in vitro and have a considerable in vitro affinity for serotonin reuptake sites. It capable of antagonizing apomorphine-induced climbing behavior, disrupting CAR activity and potentiating 5-hydroxytryptophan (5-HTP) behavior. SLV314 has also been found to antagonize amphetamine- and ketamine-stimulated locomotor activity and methylphenidate-induced gnawing and stimulated behaviors, furthermore, a significant dose discrepancy was seen between the antipsychotic and cataleptogenic effects of SLV314. Lensiprazine demonstrated putative antipsychotic and selective serotonin reuptake inhibitor potential.

CNS Activity

Approval Year

PubMed

Title	Date	PubMed
Principal component analysis differentiates the receptor binding profiles of three antipsychotic drug candidates from current antipsychotic drugs.	2007 Oct 18	17880057

Name

Type

Language

LENSIPRAZINE

Official Name

English

lensiprazine [INN]

Common Name

English

(2R)-8-(4-(3-(5-FLUORO-1H-INDOL-3-YL)PROPYL)PIPERIDIN-1-YL)-2-METHYL-2H-1,4-BENZOXAZIN-3(4H)-ONE

Systematic Name

English

Lensiprazine [WHO-DD]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C66883