Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | Cl.Rb |
| Molecular Weight | 120.921 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[Cl-].[Rb+]
InChI
InChIKey=FGDZQCVHDSGLHJ-UHFFFAOYSA-M
InChI=1S/ClH.Rb/h1H;/q;+1/p-1
DescriptionCurator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/3311597 | https://www.ncbi.nlm.nih.gov/pubmed/26442267
Curator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/3311597 | https://www.ncbi.nlm.nih.gov/pubmed/26442267
Rubidium chloride is an inorganic compound with the formula RbCl. It appears to be nontoxic and therapeutically effective in several types of depressive disorders. This drug develops his action on dopaminergic stimulation reducing the depressive pattern. Also radioactive rubidium-82 chloride is used as diagnostic agent in positron emission tomography (PET).
CNS Activity
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Brain norepinephrine: enhanced turnover after rubidium treatment. | 1970 Apr 24 |
|
| Rubidium chloride ingestion by volunteer subjects: initial experience. | 1971 |
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| Effects of rubidium chloride on the course of manic-depressive illness. | 1978 May |
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| Nerve fibre refractory period in patients treated with rubidium and lithium. | 1978 Sep |
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| Exploration of the clinical profile of rubidium chloride in depression: a systematic open trial. | 1988 Jun |
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| Effects of trace metal compounds on HIV-1 reverse transcriptase: an in vitro study. | 1999 May |
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| Inhibition of HIV-1 infection by zinc group metal compounds. | 1999 Sep |
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| Gating properties of inward-rectifier potassium channels: effects of permeant ions. | 2001 Nov 1 |
|
| Protein kinase C-epsilon modulates mitochondrial function and active Na+ transport after oxidant injury in renal cells. | 2004 Feb |
Patents
Sample Use Guides
Rubidium chloride accelerated cAMP synthesis in rat brain cortex membranes. The effect was dose-dependent and yielded above 2-fold activation of adenylate cyclase. It has been shown that Rb+ influenced directly the catalytic subunit of the enzyme and did not substitute Mg2+ in formation of the metal-ATP complex in this reaction. The stimulatory effect of Rb+ was additive to the activation of adenylate cyclase by the half-maximal (0.3 microM) as well as by the saturating (10 microM) forskolin concentrations, pointing to the fact that these effectors activate different isoforms of the enzyme in rat brain cortex.
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DSLD |
1946 (Number of products:63)
Created by
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232-240-9
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100000078861
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m9687
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C032710
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N3SHC5273S
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84273
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78672
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RUBIDIUM CHLORIDE
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1367087
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7791-11-9
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62683
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SUB15161MIG
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DTXSID5064881
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SUBSTANCE RECORD
