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Details

Stereochemistry ABSOLUTE
Molecular Formula 2C12H14NO5S.2Na.5H2O
Molecular Weight 704.672
Optical Activity ( + )
Defined Stereocenters 8 / 8
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of FAROPENEM SODIUM HEMIPENTAHYDRATE

SMILES

O.O.O.O.O.[Na+].[Na+].[H][C@]12SC(=C(N1C(=O)[C@]2([H])[C@@H](C)O)C([O-])=O)[C@@]3([H])CCCO3.[H][C@]45SC(=C(N4C(=O)[C@]5([H])[C@@H](C)O)C([O-])=O)[C@@]6([H])CCCO6

InChI

InChIKey=MOGICMVNWAUWMK-HIXRZVNASA-L
InChI=1S/2C12H15NO5S.2Na.5H2O/c2*1-5(14)7-10(15)13-8(12(16)17)9(19-11(7)13)6-3-2-4-18-6;;;;;;;/h2*5-7,11,14H,2-4H2,1H3,(H,16,17);;;5*1H2/q;;2*+1;;;;;/p-2/t2*5-,6-,7+,11-;;;;;;;/m11......./s1

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Description

Faropenem is a unique antimicrobial penem being developed for oral administration. It markets it in two forms: faropenem sodium and faropenem medoxomil. The high binding affinities of faropenem to penicillin-binding proteins from gram-negative and gram-positive bacteria are mirrored by its pronounced and concentration-dependent bactericidal effect. It is usually used to treat a wide range of infections such as skin, respiratory and otorhinologic infections. The most commonly reported adverse reactions include diarrhea, abdominal pain, loose stool, rash and nausea. The FDA refused to approve faropenem – the applicant have to conduct new studies and clinical trials to prove the drug treats community-acquired pneumonia, bacterial sinusitis, chronic bronchitis, and skin infections.

Originator

Approval Year

Targets

Primary TargetPharmacologyConditionPotency

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
Farom
Curative
Farom
Curative
Farom
Curative
Farom

PubMed

Sample Use Guides

In Vivo Use Guide
150 - 300 mg three times a day
Route of Administration: Oral
In Vitro Use Guide
Exposure of S. aureus to faropenem at minimum inhibitory concentrations (MICs) of 1/8 or 1/4 resulted in irregular septum formation. At 1x MIC or higher, a larger number of lysed cells were observed. Exposure of E. coli to 1/8x MIC or 1/4x MIC also induced changes in cellular shape; the normal rod-shaped form changed to a spherical form in a time-dependent manner. After exposure of E. coli to 1x MIC for 2 h, bulging-shaped E. coli cells were observed and after 4 h of exposure cell lysis was demonstrated. In the presence of 4x MIC, spheroplast-like forms and cell lysis were observed.