Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C65H88N14O19S2.Cu |
Molecular Weight | 1497.536 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 10 / 10 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[64Cu++].[H][C@](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](CC2=CC=CC=C2)NC(=O)CN3CCN(CC([O-])=O)CCN(CC(O)=O)CCN(CC([O-])=O)CC3)C(=O)N[C@@H](CC4=CC=C(O)C=C4)C(=O)N[C@H](CC5=CNC6=C5C=CC=C6)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1)([C@@H](C)O)C(O)=O
InChI
InChIKey=IJRLLVFQGCCPPI-NVGRTJHCSA-L
InChI=1S/C65H90N14O19S2.Cu/c1-38(80)56-64(96)73-51(63(95)75-57(39(2)81)65(97)98)37-100-99-36-50(72-59(91)47(28-40-10-4-3-5-11-40)68-52(83)32-76-20-22-77(33-53(84)85)24-26-79(35-55(88)89)27-25-78(23-21-76)34-54(86)87)62(94)70-48(29-41-15-17-43(82)18-16-41)60(92)71-49(30-42-31-67-45-13-7-6-12-44(42)45)61(93)69-46(58(90)74-56)14-8-9-19-66;/h3-7,10-13,15-18,31,38-39,46-51,56-57,67,80-82H,8-9,14,19-30,32-37,66H2,1-2H3,(H,68,83)(H,69,93)(H,70,94)(H,71,92)(H,72,91)(H,73,96)(H,74,90)(H,75,95)(H,84,85)(H,86,87)(H,88,89)(H,97,98);/q;+2/p-2/t38-,39-,46+,47-,48+,49-,50+,51+,56+,57+;/m1./s1/i;1+0
Dotatate, also known as DOTA-0-Tyr3-Octreotate, is a cyclic 8 amino acid peptide with a covalently bound chelator (dota). The peptide has the amino acid sequence: H-D-Phe-Cys-Tyr-D-Trp-Lys-ThrCys-Thr-OH, and contains one disulfide bond. After radiolabeling with Ga 68 (NETSPOT®) or with Lu 177 (LUTATHERA®), it is indicated for use with positron emission tomography (PET) for localization of somatostatin receptor positive neuroendocrine tumors (NETs) in adult and pediatric patients.
Approval Year
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Inactive ingredient | NETSPOT Approved UseNetspot, after radiolabeling with Ga 68, is indicated for use with positron emission tomography (PET) for localization of somatostatin receptor positive neuroendocrine tumors (NETs) in adult and pediatric patients. Launch Date2016 |
Name | Type | Language | ||
---|---|---|---|---|
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Brand Name | English | ||
|
Systematic Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English |
Classification Tree | Code System | Code | ||
---|---|---|---|---|
|
FDA ORPHAN DRUG |
520716
Created by
admin on Sat Dec 16 12:33:16 GMT 2023 , Edited by admin on Sat Dec 16 12:33:16 GMT 2023
|
Code System | Code | Type | Description | ||
---|---|---|---|---|---|
|
C173524
Created by
admin on Sat Dec 16 12:33:16 GMT 2023 , Edited by admin on Sat Dec 16 12:33:16 GMT 2023
|
PRIMARY | |||
|
300000039570
Created by
admin on Sat Dec 16 12:33:16 GMT 2023 , Edited by admin on Sat Dec 16 12:33:16 GMT 2023
|
PRIMARY | |||
|
HI-25
Created by
admin on Sat Dec 16 12:33:16 GMT 2023 , Edited by admin on Sat Dec 16 12:33:16 GMT 2023
|
PRIMARY | |||
|
Copper (64Cu) oxodotreotide
Created by
admin on Sat Dec 16 12:33:16 GMT 2023 , Edited by admin on Sat Dec 16 12:33:16 GMT 2023
|
PRIMARY | |||
|
2396442
Created by
admin on Sat Dec 16 12:33:16 GMT 2023 , Edited by admin on Sat Dec 16 12:33:16 GMT 2023
|
PRIMARY | |||
|
DTXSID901336538
Created by
admin on Sat Dec 16 12:33:16 GMT 2023 , Edited by admin on Sat Dec 16 12:33:16 GMT 2023
|
PRIMARY | |||
|
N3858377KC
Created by
admin on Sat Dec 16 12:33:16 GMT 2023 , Edited by admin on Sat Dec 16 12:33:16 GMT 2023
|
PRIMARY | |||
|
1426155-87-4
Created by
admin on Sat Dec 16 12:33:16 GMT 2023 , Edited by admin on Sat Dec 16 12:33:16 GMT 2023
|
NON-SPECIFIC STEREOCHEMISTRY | |||
|
124220636
Created by
admin on Sat Dec 16 12:33:16 GMT 2023 , Edited by admin on Sat Dec 16 12:33:16 GMT 2023
|
PRIMARY | |||
|
N3858377KC
Created by
admin on Sat Dec 16 12:33:16 GMT 2023 , Edited by admin on Sat Dec 16 12:33:16 GMT 2023
|
PRIMARY |
ACTIVE MOIETY
SUBSTANCE RECORD