U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C24H36ClN3O2
Molecular Weight 434.015
Optical Activity UNSPECIFIED
Defined Stereocenters 2 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of LIREXAPRIDE

SMILES

CC1CCN(C[C@H]2CCCC[C@H]2NC(=O)C3=CC(Cl)=C(N)C=C3OCC4CC4)CC1

InChI

InChIKey=PPVTTWPBNHFCAJ-XMSQKQJNSA-N
InChI=1S/C24H36ClN3O2/c1-16-8-10-28(11-9-16)14-18-4-2-3-5-22(18)27-24(29)19-12-20(25)21(26)13-23(19)30-15-17-6-7-17/h12-13,16-18,22H,2-11,14-15,26H2,1H3,(H,27,29)/t18-,22-/m1/s1

HIDE SMILES / InChI
Lirexapride serotonin 5-HT4 receptor and dopamine D2 receptor agonists. It had been in phase II clinical trials for the treatment of irritable bowel syndrome. However, this research has been discontinued.

Approval Year

PubMed

PubMed

TitleDatePubMed
Emerging drugs for functional dyspepsia.
2011 Jun
Systematic review: cardiovascular safety profile of 5-HT(4) agonists developed for gastrointestinal disorders.
2012 Apr
Name Type Language
LIREXAPRIDE
INN  
INN  
Official Name English
4-AMINO-5-CHLORO-.ALPHA.-CYCLOPROPYL-N-((1R,2R)-2-((4-METHYLPIPERIDINO)METHYL)CYCLOHEXYL)-O-ANISAMIDE
Common Name English
lirexapride [INN]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C47794
Created by admin on Fri Dec 15 16:15:15 GMT 2023 , Edited by admin on Fri Dec 15 16:15:15 GMT 2023
Code System Code Type Description
NCI_THESAURUS
C80762
Created by admin on Fri Dec 15 16:15:15 GMT 2023 , Edited by admin on Fri Dec 15 16:15:15 GMT 2023
PRIMARY
PUBCHEM
3045376
Created by admin on Fri Dec 15 16:15:15 GMT 2023 , Edited by admin on Fri Dec 15 16:15:15 GMT 2023
PRIMARY
EVMPD
SUB08530MIG
Created by admin on Fri Dec 15 16:15:15 GMT 2023 , Edited by admin on Fri Dec 15 16:15:15 GMT 2023
PRIMARY
SMS_ID
100000082523
Created by admin on Fri Dec 15 16:15:15 GMT 2023 , Edited by admin on Fri Dec 15 16:15:15 GMT 2023
PRIMARY
FDA UNII
N33SZ2N85M
Created by admin on Fri Dec 15 16:15:15 GMT 2023 , Edited by admin on Fri Dec 15 16:15:15 GMT 2023
PRIMARY
ChEMBL
CHEMBL2107144
Created by admin on Fri Dec 15 16:15:15 GMT 2023 , Edited by admin on Fri Dec 15 16:15:15 GMT 2023
PRIMARY
CAS
145414-12-6
Created by admin on Fri Dec 15 16:15:15 GMT 2023 , Edited by admin on Fri Dec 15 16:15:15 GMT 2023
PRIMARY
INN
7418
Created by admin on Fri Dec 15 16:15:15 GMT 2023 , Edited by admin on Fri Dec 15 16:15:15 GMT 2023
PRIMARY
EPA CompTox
DTXSID20163005
Created by admin on Fri Dec 15 16:15:15 GMT 2023 , Edited by admin on Fri Dec 15 16:15:15 GMT 2023
PRIMARY