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Details

Stereochemistry ACHIRAL
Molecular Formula C26H35N3O2
Molecular Weight 421.575
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of MAZAPERTINE

SMILES

CC(C)OC1=C(C=CC=C1)N2CCN(CC3=CC=CC(=C3)C(=O)N4CCCCC4)CC2

InChI

InChIKey=ZKZFPRUSWCYSGT-UHFFFAOYSA-N
InChI=1S/C26H35N3O2/c1-21(2)31-25-12-5-4-11-24(25)28-17-15-27(16-18-28)20-22-9-8-10-23(19-22)26(30)29-13-6-3-7-14-29/h4-5,8-12,19,21H,3,6-7,13-18,20H2,1-2H3

HIDE SMILES / InChI
Mazapertine (RWJ-37796) is an arylpiperazine antipsychotic with high affinity to dopamine D2 and D3, serotonin 5-HT1A and alpha 1A-adrenergic receptors. It was being studied in the treatment of schizophrenia.

Approval Year

PubMed

PubMed

TitleDatePubMed

Sample Use Guides

healthy male subjects received incremental oral doses of mazapertine (from 5 to 50 mg over 7 days; n = 10) or placebo (n = 3) in part I and single doses in parts II (20 or 30 mg or placebo) and III (40 mg or placebo) in a double-blind fashion.
Route of Administration: Oral
Name Type Language
MAZAPERTINE
INN   WHO-DD  
INN  
Official Name English
Mazapertine [WHO-DD]
Common Name English
PIPERIDINE, 1-(3-((4-(2-(1-METHYLETHOXY)PHENYL)-1-PIPERAZINYL)METHYL)BENZOYL)-
Systematic Name English
1-(.ALPHA.-(4-(O-ISOPROPOXYPHENYL)-1-PIPERAZINYL)-M-TOLUOYL)PIPERIDINE
Common Name English
mazapertine [INN]
Common Name English
Code System Code Type Description
INN
7300
Created by admin on Fri Dec 15 17:19:13 GMT 2023 , Edited by admin on Fri Dec 15 17:19:13 GMT 2023
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FDA UNII
N0X1XW704P
Created by admin on Fri Dec 15 17:19:13 GMT 2023 , Edited by admin on Fri Dec 15 17:19:13 GMT 2023
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EVMPD
SUB08654MIG
Created by admin on Fri Dec 15 17:19:13 GMT 2023 , Edited by admin on Fri Dec 15 17:19:13 GMT 2023
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CAS
134208-17-6
Created by admin on Fri Dec 15 17:19:13 GMT 2023 , Edited by admin on Fri Dec 15 17:19:13 GMT 2023
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SMS_ID
100000081746
Created by admin on Fri Dec 15 17:19:13 GMT 2023 , Edited by admin on Fri Dec 15 17:19:13 GMT 2023
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WIKIPEDIA
MAZAPERTINE
Created by admin on Fri Dec 15 17:19:13 GMT 2023 , Edited by admin on Fri Dec 15 17:19:13 GMT 2023
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NCI_THESAURUS
C174731
Created by admin on Fri Dec 15 17:19:13 GMT 2023 , Edited by admin on Fri Dec 15 17:19:13 GMT 2023
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PUBCHEM
60820
Created by admin on Fri Dec 15 17:19:13 GMT 2023 , Edited by admin on Fri Dec 15 17:19:13 GMT 2023
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EPA CompTox
DTXSID40158594
Created by admin on Fri Dec 15 17:19:13 GMT 2023 , Edited by admin on Fri Dec 15 17:19:13 GMT 2023
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ChEMBL
CHEMBL10085
Created by admin on Fri Dec 15 17:19:13 GMT 2023 , Edited by admin on Fri Dec 15 17:19:13 GMT 2023
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