U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C8H10O
Molecular Weight 122.1644
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PHENYLETHYL ALCOHOL

SMILES

OCCC1=CC=CC=C1

InChI

InChIKey=WRMNZCZEMHIOCP-UHFFFAOYSA-N
InChI=1S/C8H10O/c9-7-6-8-4-2-1-3-5-8/h1-5,9H,6-7H2

HIDE SMILES / InChI
Phenethyl alcohol, or 2-phenylethanol, is an aromatic alcohol with a rosy scent. It is widely used in the food, fragrance, and cosmetic industries. It is used in the formulation of eye area makeup, skin care products, shampoos, perfumes, and colognes. Promising sources of natural 2-phenylethanol are microorganisms, especially yeasts, which can produce it by biosynthesis and biotransformation.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Inactive ingredient
KLEER-PLEX ADVANCED ACNE CARE SYSTEM

Approved Use

Acne Treatment. - For the management of acne. - Clears up most acne pimples, blackheads, and whiteheads and allows skin to heal. - Penetrates pores to eliminate most acne blemishes. - Helps prevent new acne pimples.
PubMed

PubMed

TitleDatePubMed
Antioxidative activity of volatile chemicals extracted from beer.
2001 Aug
Estrogenic activity of phenolic compounds from Nigella damascena evaluated using a recombinant yeast screen.
2001 Aug
Caffeic acid phenethyl ester, an inhibitor of nuclear factor-kappaB, attenuates bacterial peptidoglycan polysaccharide-induced colitis in rats.
2001 Dec
NMR separation of beta-prochiral protons to the ether oxygen of chiral esters with lanthanide shift reagents.
2001 Dec 27
The antioxidant caffeic acid phenethyl ester induces apoptosis associated with selective scavenging of hydrogen peroxide in human leukemic HL-60 cells.
2001 Feb
Oxidation of p-hydroxybenzoic acid by Fenton's reagent.
2001 Feb
Caffeic acid phenethyl ester (CAPE): synthesis and X-ray crystallographic analysis.
2001 Feb
Prochiral selectivity in H(2)O(2)-promoted oxidation of arylalkanols catalysed by chloroperoxidase. The role of the interactions between the OH group and the amino-acid residues in the enzyme active site.
2001 Feb
Tyrosol bioavailability in humans after ingestion of virgin olive oil.
2001 Feb
Modulation of the biosynthesis of some phenolic compounds in Olea europaea L. fruits: their influence on olive oil quality.
2001 Jan
Synthesis of tropane and nortropane analogues with phenyl substitutions as serotonin transporter ligands.
2001 Jul
Diazepam submicron emulsions containing soya-bean oil and intended for oral or rectal delivery.
2001 Mar
Tyrosine and phenylalanine catabolism by Lactobacillus cheese flavor adjuncts.
2001 May
Three new glycosides from Sinopodophyllum emodi (Wall.) Ying.
2001 Nov
Effect of caffeic acid phenethyl ester, an antioxidant from propolis, on inducing apoptosis in human leukemic HL-60 cells.
2001 Nov
Pharmacokinetics and metabolism of hydroxytyrosol, a natural antioxidant from olive oil.
2001 Nov
Effect of some white wine phenols in preventing inflammatory cytokine release.
2002
Comparison of radical scavenging effect, inhibition of microsomal oxygen free radical generation, and serum lipoprotein oxidation of several natural antioxidants.
2002 Apr 10
Structural characterization of the metabolites of hydroxytyrosol, the principal phenolic component in olive oil, in rats.
2002 Apr 10
Volatile metabolites from actinomycetes.
2002 Apr 24
Continuous green biocatalytic processes using ionic liquids and supercritical carbon dioxide.
2002 Apr 7
Cancer chemoprevention by hydroxytyrosol isolated from virgin olive oil through G1 cell cycle arrest and apoptosis.
2002 Aug
Accumulation of tyrosol glucoside in transgenic potato plants expressing a parsley tyrosine decarboxylase.
2002 Aug
The effect of the nature of H-bonding groups on diffusion through PDMS membranes saturated with octanol and toluene.
2002 Feb
Molecular cloning, expression and characterization of tropinone reductase II, an enzyme of the SDR family in Solanum tuberosum (L.).
2002 Feb 1
Bioactive derivatives from oleuropein by a biotransformation on Olea europaea leaf extracts.
2002 Feb 14
Application of pulsed field gradient NMR techniques for investigating binding of flavor compounds to macromolecules.
2002 Jul 17
Lateralization in human nasal chemoreception: differences in bilateral electrodermal responses related to olfactory and trigeminal stimuli.
2002 Jul 18
Biotechnological production of 2-phenylethanol.
2002 Jun
Hydroxytyrosol 4-beta-D-glucoside, an important phenolic compound in olive fruits and derived products.
2002 Jun 19
Selective antiproliferative activity of caffeic acid phenethyl ester analogues on highly liver-metastatic murine colon 26-L5 carcinoma cell line.
2002 Oct
Germination and growth inhibitors from wheat (Triticum aestivum L.) husks.
2002 Oct 23
Comparison of lateralized and binasal olfactory thresholds.
2002 Sep
The protective role of caffeic acid phenethyl ester (CAPE) on testicular tissue after testicular torsion and detorsion.
2002 Sep
Effect of different strains of Saccharomyces cerevisiae on production of volatiles in Napa Gamay wine and Petite Sirah wine.
2002 Sep 25
Use of inverse gas chromatography to characterize cotton fabrics and their interactions with fragrance molecules at controlled relative humidity.
2002 Sep 6
Patents

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
Unknown
Name Type Language
PHENYLETHYL ALCOHOL
FHFI   HSDB   II   USP   USP-RS  
Systematic Name English
PHENYLETHYL ALCOHOL [II]
Common Name English
PHENETHYL ALCOHOL [FCC]
Common Name English
PHENYLETHYL ALCOHOL [USP-RS]
Common Name English
PHENYLETHYL ALCOHOL [FHFI]
Common Name English
PHENETHYL ALCOHOL [MI]
Common Name English
Phenethyl alcohol
FCC   INCI   MART.   MI   WHO-DD  
INCI  
Official Name English
.BETA.-HYDROXYETHYLBENZENE
Systematic Name English
BENZENEETHANOL
Systematic Name English
PHENYLETHANOL
Systematic Name English
PHENYLETHYL ALCOHOL [HSDB]
Common Name English
NSC-406252
Code English
2-PHENYLETHANOL
Systematic Name English
Phenethyl alcohol [WHO-DD]
Common Name English
PHENYLETHYL ALCOHOL [USP MONOGRAPH]
Common Name English
FEMA NO. 2858
Code English
PHENETHYL ALCOHOL [INCI]
Common Name English
PHENETHYL ALCOHOL [MART.]
Common Name English
.BETA.-(HYDROXYETHYL)BENZENE
Common Name English
(2-HYDROXYETHYL)BENZENE
Systematic Name English
.BETA.-PHENYLETHYL ALCOHOL
Systematic Name English
Classification Tree Code System Code
CFR 21 CFR 172.515
Created by admin on Fri Dec 15 15:03:36 GMT 2023 , Edited by admin on Fri Dec 15 15:03:36 GMT 2023
NCI_THESAURUS C28394
Created by admin on Fri Dec 15 15:03:36 GMT 2023 , Edited by admin on Fri Dec 15 15:03:36 GMT 2023
EPA PESTICIDE CODE 1503
Created by admin on Fri Dec 15 15:03:36 GMT 2023 , Edited by admin on Fri Dec 15 15:03:36 GMT 2023
JECFA EVALUATION PHENETHYL ALCOHOL
Created by admin on Fri Dec 15 15:03:36 GMT 2023 , Edited by admin on Fri Dec 15 15:03:36 GMT 2023
Code System Code Type Description
HSDB
5002
Created by admin on Fri Dec 15 15:03:36 GMT 2023 , Edited by admin on Fri Dec 15 15:03:36 GMT 2023
PRIMARY
MESH
D010626
Created by admin on Fri Dec 15 15:03:36 GMT 2023 , Edited by admin on Fri Dec 15 15:03:36 GMT 2023
PRIMARY
DRUG BANK
DB02192
Created by admin on Fri Dec 15 15:03:36 GMT 2023 , Edited by admin on Fri Dec 15 15:03:36 GMT 2023
PRIMARY
MERCK INDEX
m8608
Created by admin on Fri Dec 15 15:03:36 GMT 2023 , Edited by admin on Fri Dec 15 15:03:36 GMT 2023
PRIMARY Merck Index
ChEMBL
CHEMBL448500
Created by admin on Fri Dec 15 15:03:36 GMT 2023 , Edited by admin on Fri Dec 15 15:03:36 GMT 2023
PRIMARY
SMS_ID
100000115780
Created by admin on Fri Dec 15 15:03:36 GMT 2023 , Edited by admin on Fri Dec 15 15:03:36 GMT 2023
PRIMARY
ECHA (EC/EINECS)
200-456-2
Created by admin on Fri Dec 15 15:03:36 GMT 2023 , Edited by admin on Fri Dec 15 15:03:36 GMT 2023
PRIMARY
RS_ITEM_NUM
1533250
Created by admin on Fri Dec 15 15:03:36 GMT 2023 , Edited by admin on Fri Dec 15 15:03:36 GMT 2023
PRIMARY
CAS
60-12-8
Created by admin on Fri Dec 15 15:03:36 GMT 2023 , Edited by admin on Fri Dec 15 15:03:36 GMT 2023
PRIMARY
RXCUI
8126
Created by admin on Fri Dec 15 15:03:36 GMT 2023 , Edited by admin on Fri Dec 15 15:03:36 GMT 2023
PRIMARY RxNorm
CAS
1321-27-3
Created by admin on Fri Dec 15 15:03:36 GMT 2023 , Edited by admin on Fri Dec 15 15:03:36 GMT 2023
NON-SPECIFIC SUBSTITUTION
PUBCHEM
6054
Created by admin on Fri Dec 15 15:03:36 GMT 2023 , Edited by admin on Fri Dec 15 15:03:36 GMT 2023
PRIMARY
EVMPD
SUB31102
Created by admin on Fri Dec 15 15:03:36 GMT 2023 , Edited by admin on Fri Dec 15 15:03:36 GMT 2023
PRIMARY
EPA CompTox
DTXSID9026342
Created by admin on Fri Dec 15 15:03:36 GMT 2023 , Edited by admin on Fri Dec 15 15:03:36 GMT 2023
PRIMARY
FDA UNII
ML9LGA7468
Created by admin on Fri Dec 15 15:03:36 GMT 2023 , Edited by admin on Fri Dec 15 15:03:36 GMT 2023
PRIMARY
NSC
406252
Created by admin on Fri Dec 15 15:03:36 GMT 2023 , Edited by admin on Fri Dec 15 15:03:36 GMT 2023
PRIMARY
WIKIPEDIA
PHENETHYL ALCOHOL
Created by admin on Fri Dec 15 15:03:36 GMT 2023 , Edited by admin on Fri Dec 15 15:03:36 GMT 2023
PRIMARY
NCI_THESAURUS
C77399
Created by admin on Fri Dec 15 15:03:36 GMT 2023 , Edited by admin on Fri Dec 15 15:03:36 GMT 2023
PRIMARY
JECFA MONOGRAPH
920
Created by admin on Fri Dec 15 15:03:36 GMT 2023 , Edited by admin on Fri Dec 15 15:03:36 GMT 2023
PRIMARY
CHEBI
49000
Created by admin on Fri Dec 15 15:03:36 GMT 2023 , Edited by admin on Fri Dec 15 15:03:36 GMT 2023
PRIMARY
DAILYMED
ML9LGA7468
Created by admin on Fri Dec 15 15:03:36 GMT 2023 , Edited by admin on Fri Dec 15 15:03:36 GMT 2023
PRIMARY