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Details

Stereochemistry ABSOLUTE
Molecular Formula C37H62O12
Molecular Weight 698.881
Optical Activity UNSPECIFIED
Defined Stereocenters 17 / 17
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of LAIDLOMYCIN

SMILES

[H][C@@]1(C[C@H](C)[C@@]([H])(O1)[C@]2(C)CC[C@@]([H])(O2)[C@]3(C)CC[C@]4(C[C@H](O)[C@@H](C)[C@]([H])(O4)[C@@H](C)[C@@H](OC(=O)CC)[C@H](C)C(O)=O)O3)[C@@]5([H])O[C@@](O)(CO)[C@H](C)C[C@@H]5C

InChI

InChIKey=ZNBNBTIDJSKEAM-NISBWGIBSA-N
InChI=1S/C37H62O12/c1-10-28(40)45-30(24(7)33(41)42)23(6)31-22(5)25(39)17-36(47-31)14-13-34(8,49-36)27-11-12-35(9,46-27)32-20(3)16-26(44-32)29-19(2)15-21(4)37(43,18-38)48-29/h19-27,29-32,38-39,43H,10-18H2,1-9H3,(H,41,42)/t19-,20-,21+,22+,23-,24-,25-,26+,27+,29-,30+,31-,32+,34-,35-,36+,37-/m0/s1

HIDE SMILES / InChI
Laidlomycin is a polycyclic polyether antibiotic which possesses an inhibitory activity against various mycoplasma species}, and is effective in controlling coccidiosis in chickens. It is also known as selectively inhibiting the migration of hemagglutinin glycoprotein from Golgi apparatus to the cell surface in measles virus). Laidlomycin inhibited growth of some Gram-positive bacteria only at high concentrations such as 50-100 ug/ml, but was not active against Gram-negative bacteria, yeast and fungi even at concentration of 1,000 ug/ml. In broth dilution, laidlomycin was active against several illycoplasmas and most active against the sterol-nonrequiring mycoplasma, Acholeplasma laidlawii. Under the brand name Cattlyst Laidlomycin is indicated for improved feed efficiency and increased rate of weight gain in cattle fed in confinement for slaughter.

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown

Approved Use

Unknown
Primary
Cattlyst

Approved Use

For improved feed efficiency and increased rate of weight gain in cattle fed in confinement for slaughter

Launch Date

1994
PubMed

PubMed

TitleDatePubMed
Production and biological activity of laidlomycin, anti-MRSA/VRE antibiotic from Streptomyces sp. CS684.
2007 Feb
Monoclonal antibody production and immunochemical detection of polyether antibiotics.
2009 Mar
Patents

Sample Use Guides

Laidlomycin propionate promix, 50 g of laidlomycin propionate potassium per pound. Laidlomycin propionate premix should be admixed into feed and fed at a dietary concentration of 5 to 10 g of laidlomycin propionate/ton of feed (90% dry matter basis) to provide not less than 30 nor more than 150 mg/animal/day.
Route of Administration: Oral
Laidlomycin propionate (16.2 mM) decreased (P < 0.02) glucose absorption, as estimated by H3-3-O-methyl glucose uptake compared with all other treatments of murine jejunal rings, whereas laidlomycin propionate (1.62 mM) increased (P = 0.032) jejunal DM content compared with 16.2 mM laidlomycin propionate.
Name Type Language
LAIDLOMYCIN
INN   MI  
INN  
Official Name English
MONENSIN, 16-DEETHYL-3-O-DEMETHYL-16-METHYL-3-O-(1-OXOPROPYL)-
Common Name English
LAIDLOMYCIN [MI]
Common Name English
laidlomycin [INN]
Common Name English
Classification Tree Code System Code
CFR 21 CFR 558.305
Created by admin on Fri Dec 15 17:13:25 GMT 2023 , Edited by admin on Fri Dec 15 17:13:25 GMT 2023
NCI_THESAURUS C258
Created by admin on Fri Dec 15 17:13:25 GMT 2023 , Edited by admin on Fri Dec 15 17:13:25 GMT 2023
CFR 21 CFR 556.346
Created by admin on Fri Dec 15 17:13:25 GMT 2023 , Edited by admin on Fri Dec 15 17:13:25 GMT 2023
Code System Code Type Description
ChEMBL
CHEMBL2110869
Created by admin on Fri Dec 15 17:13:25 GMT 2023 , Edited by admin on Fri Dec 15 17:13:25 GMT 2023
PRIMARY
MESH
C010208
Created by admin on Fri Dec 15 17:13:25 GMT 2023 , Edited by admin on Fri Dec 15 17:13:25 GMT 2023
PRIMARY
FDA UNII
MI3S6ZF5QE
Created by admin on Fri Dec 15 17:13:25 GMT 2023 , Edited by admin on Fri Dec 15 17:13:25 GMT 2023
PRIMARY
INN
6483
Created by admin on Fri Dec 15 17:13:25 GMT 2023 , Edited by admin on Fri Dec 15 17:13:25 GMT 2023
PRIMARY
RXCUI
1546426
Created by admin on Fri Dec 15 17:13:25 GMT 2023 , Edited by admin on Fri Dec 15 17:13:25 GMT 2023
PRIMARY RxNorm
PUBCHEM
71454116
Created by admin on Fri Dec 15 17:13:25 GMT 2023 , Edited by admin on Fri Dec 15 17:13:25 GMT 2023
PRIMARY
CAS
56283-74-0
Created by admin on Fri Dec 15 17:13:25 GMT 2023 , Edited by admin on Fri Dec 15 17:13:25 GMT 2023
PRIMARY
NCI_THESAURUS
C79533
Created by admin on Fri Dec 15 17:13:25 GMT 2023 , Edited by admin on Fri Dec 15 17:13:25 GMT 2023
PRIMARY
EPA CompTox
DTXSID401024015
Created by admin on Fri Dec 15 17:13:25 GMT 2023 , Edited by admin on Fri Dec 15 17:13:25 GMT 2023
PRIMARY
DAILYMED
MI3S6ZF5QE
Created by admin on Fri Dec 15 17:13:25 GMT 2023 , Edited by admin on Fri Dec 15 17:13:25 GMT 2023
PRIMARY
EVMPD
SUB08390MIG
Created by admin on Fri Dec 15 17:13:25 GMT 2023 , Edited by admin on Fri Dec 15 17:13:25 GMT 2023
PRIMARY
ECHA (EC/EINECS)
260-095-1
Created by admin on Fri Dec 15 17:13:25 GMT 2023 , Edited by admin on Fri Dec 15 17:13:25 GMT 2023
PRIMARY
MERCK INDEX
m6667
Created by admin on Fri Dec 15 17:13:25 GMT 2023 , Edited by admin on Fri Dec 15 17:13:25 GMT 2023
PRIMARY Merck Index
SMS_ID
100000082531
Created by admin on Fri Dec 15 17:13:25 GMT 2023 , Edited by admin on Fri Dec 15 17:13:25 GMT 2023
PRIMARY