Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C37H62O12 |
Molecular Weight | 698.881 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 17 / 17 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@@]1(C[C@H](C)[C@@]([H])(O1)[C@]2(C)CC[C@@]([H])(O2)[C@]3(C)CC[C@]4(C[C@H](O)[C@@H](C)[C@]([H])(O4)[C@@H](C)[C@@H](OC(=O)CC)[C@H](C)C(O)=O)O3)[C@@]5([H])O[C@@](O)(CO)[C@H](C)C[C@@H]5C
InChI
InChIKey=ZNBNBTIDJSKEAM-NISBWGIBSA-N
InChI=1S/C37H62O12/c1-10-28(40)45-30(24(7)33(41)42)23(6)31-22(5)25(39)17-36(47-31)14-13-34(8,49-36)27-11-12-35(9,46-27)32-20(3)16-26(44-32)29-19(2)15-21(4)37(43,18-38)48-29/h19-27,29-32,38-39,43H,10-18H2,1-9H3,(H,41,42)/t19-,20-,21+,22+,23-,24-,25-,26+,27+,29-,30+,31-,32+,34-,35-,36+,37-/m0/s1
Laidlomycin is a polycyclic polyether antibiotic which possesses an inhibitory activity against various mycoplasma species}, and is effective in controlling coccidiosis in chickens. It is also known as selectively inhibiting the
migration of hemagglutinin glycoprotein from Golgi apparatus to the cell surface in measles virus). Laidlomycin inhibited growth of some Gram-positive bacteria only at high concentrations such as 50-100 ug/ml,
but was not active against Gram-negative bacteria,
yeast and fungi even at concentration of 1,000 ug/ml. In broth dilution, laidlomycin was active against several illycoplasmas and most active against the sterol-nonrequiring mycoplasma, Acholeplasma laidlawii. Under the brand name Cattlyst Laidlomycin is indicated for improved feed efficiency and increased rate of weight gain in cattle fed in confinement for slaughter.
Originator
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL378 Sources: https://www.ncbi.nlm.nih.gov/pubmed/11099233 |
|||
Target ID: CHEMBL612313 Sources: https://www.ncbi.nlm.nih.gov/pubmed/9814916 |
|||
Target ID: GO:0006811 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Primary | Unknown Approved UseUnknown |
|||
Primary | Cattlyst Approved UseFor improved feed efficiency and increased rate of weight gain in cattle fed in confinement for slaughter Launch Date1994 |
Sample Use Guides
In Vivo Use Guide
Sources: http://www.betterchem.com/vet/laidlomycin.htm
Laidlomycin propionate promix, 50 g of laidlomycin propionate potassium per pound. Laidlomycin propionate premix should be admixed into feed and fed at a dietary concentration of 5 to 10 g of laidlomycin propionate/ton of feed (90% dry matter basis) to provide not less than 30 nor more than 150 mg/animal/day.
Route of Administration:
Oral
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/12926789
Laidlomycin propionate (16.2 mM) decreased (P < 0.02) glucose absorption, as estimated by H3-3-O-methyl glucose uptake compared with all other treatments of murine jejunal rings, whereas laidlomycin propionate (1.62 mM) increased (P = 0.032) jejunal DM content compared with 16.2 mM laidlomycin propionate.
Name | Type | Language | ||
---|---|---|---|---|
|
Official Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English |
Classification Tree | Code System | Code | ||
---|---|---|---|---|
|
CFR |
21 CFR 558.305
Created by
admin on Fri Dec 15 17:13:25 GMT 2023 , Edited by admin on Fri Dec 15 17:13:25 GMT 2023
|
||
|
NCI_THESAURUS |
C258
Created by
admin on Fri Dec 15 17:13:25 GMT 2023 , Edited by admin on Fri Dec 15 17:13:25 GMT 2023
|
||
|
CFR |
21 CFR 556.346
Created by
admin on Fri Dec 15 17:13:25 GMT 2023 , Edited by admin on Fri Dec 15 17:13:25 GMT 2023
|
Code System | Code | Type | Description | ||
---|---|---|---|---|---|
|
CHEMBL2110869
Created by
admin on Fri Dec 15 17:13:25 GMT 2023 , Edited by admin on Fri Dec 15 17:13:25 GMT 2023
|
PRIMARY | |||
|
C010208
Created by
admin on Fri Dec 15 17:13:25 GMT 2023 , Edited by admin on Fri Dec 15 17:13:25 GMT 2023
|
PRIMARY | |||
|
MI3S6ZF5QE
Created by
admin on Fri Dec 15 17:13:25 GMT 2023 , Edited by admin on Fri Dec 15 17:13:25 GMT 2023
|
PRIMARY | |||
|
6483
Created by
admin on Fri Dec 15 17:13:25 GMT 2023 , Edited by admin on Fri Dec 15 17:13:25 GMT 2023
|
PRIMARY | |||
|
1546426
Created by
admin on Fri Dec 15 17:13:25 GMT 2023 , Edited by admin on Fri Dec 15 17:13:25 GMT 2023
|
PRIMARY | RxNorm | ||
|
71454116
Created by
admin on Fri Dec 15 17:13:25 GMT 2023 , Edited by admin on Fri Dec 15 17:13:25 GMT 2023
|
PRIMARY | |||
|
56283-74-0
Created by
admin on Fri Dec 15 17:13:25 GMT 2023 , Edited by admin on Fri Dec 15 17:13:25 GMT 2023
|
PRIMARY | |||
|
C79533
Created by
admin on Fri Dec 15 17:13:25 GMT 2023 , Edited by admin on Fri Dec 15 17:13:25 GMT 2023
|
PRIMARY | |||
|
DTXSID401024015
Created by
admin on Fri Dec 15 17:13:25 GMT 2023 , Edited by admin on Fri Dec 15 17:13:25 GMT 2023
|
PRIMARY | |||
|
MI3S6ZF5QE
Created by
admin on Fri Dec 15 17:13:25 GMT 2023 , Edited by admin on Fri Dec 15 17:13:25 GMT 2023
|
PRIMARY | |||
|
SUB08390MIG
Created by
admin on Fri Dec 15 17:13:25 GMT 2023 , Edited by admin on Fri Dec 15 17:13:25 GMT 2023
|
PRIMARY | |||
|
260-095-1
Created by
admin on Fri Dec 15 17:13:25 GMT 2023 , Edited by admin on Fri Dec 15 17:13:25 GMT 2023
|
PRIMARY | |||
|
m6667
Created by
admin on Fri Dec 15 17:13:25 GMT 2023 , Edited by admin on Fri Dec 15 17:13:25 GMT 2023
|
PRIMARY | Merck Index | ||
|
100000082531
Created by
admin on Fri Dec 15 17:13:25 GMT 2023 , Edited by admin on Fri Dec 15 17:13:25 GMT 2023
|
PRIMARY |
ACTIVE MOIETY