| Stereochemistry | ABSOLUTE |
| Molecular Formula | C22H19N3O4 |
| Molecular Weight | 389.404 |
| Optical Activity | ( + ) |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CN1CC(=O)N2[C@H](CC3=C(NC4=CC=CC=C34)[C@@H]2C5=CC=C6OCOC6=C5)C1=O
InChI
InChIKey=WOXKDUGGOYFFRN-IERDGZPVSA-N
InChI=1S/C22H19N3O4/c1-24-10-19(26)25-16(22(24)27)9-14-13-4-2-3-5-15(13)23-20(14)21(25)12-6-7-17-18(8-12)29-11-28-17/h2-8,16,21,23H,9-11H2,1H3/t16-,21+/m1/s1
(6S ,12AR)-Tadalafil is an inactive diastereomer of "Tadalafil" which is the active ingredient in Cialis which is used to treat erectile dysfunction. Tadalafil has 4 isomers [(RR), (SS), (RS), and (SR)], of which (RR) is the name-sake isomer and potent inhibitor of phosphodiesterase-5. The (RS) diastereomer is the only other isomer with some PDE-5 inhibitory activity.
Originator
Approval Year
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
PubMed
SUBSTANCE RECORD
