Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C25H33N5O3 |
| Molecular Weight | 451.5612 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CNC(=O)N1N=C(C2=CC=C(C=C2)N3CCN(C)CC3)C4=CC(OC)=C(OC)C=C4C[C@@H]1C
InChI
InChIKey=CJIPEACKIJJYED-KRWDZBQOSA-N
InChI=1S/C25H33N5O3/c1-17-14-19-15-22(32-4)23(33-5)16-21(19)24(27-30(17)25(31)26-2)18-6-8-20(9-7-18)29-12-10-28(3)11-13-29/h6-9,15-17H,10-14H2,1-5H3,(H,26,31)/t17-/m0/s1
Approval Year
Cmax
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
10.17 μg/L EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/30711772/ |
10 mg single, oral dose: 10 mg route of administration: Oral experiment type: SINGLE co-administered: |
BAY-1238097 plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE food status: FASTED |
|
54.9 μg/L EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/30711772/ |
40 mg single, oral dose: 40 mg route of administration: Oral experiment type: SINGLE co-administered: |
BAY-1238097 plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE food status: FASTED |
|
118.53 μg/L EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/30711772/ |
80 mg single, oral dose: 80 mg route of administration: Oral experiment type: SINGLE co-administered: |
BAY-1238097 plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE food status: FASTED |
|
9.56 μg/L EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/30711772/ |
10 mg 1 times / week multiple, oral dose: 10 mg route of administration: Oral experiment type: MULTIPLE co-administered: |
BAY-1238097 plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE food status: FASTED |
|
68.5 μg/L EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/30711772/ |
40 mg 1 times / week multiple, oral dose: 40 mg route of administration: Oral experiment type: MULTIPLE co-administered: |
BAY-1238097 plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE food status: FASTED |
|
168.83 μg/L EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/30711772/ |
80 mg 1 times / week multiple, oral dose: 80 mg route of administration: Oral experiment type: MULTIPLE co-administered: |
BAY-1238097 plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE food status: FASTED |
AUC
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
141.7 μg × h/L EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/30711772/ |
10 mg single, oral dose: 10 mg route of administration: Oral experiment type: SINGLE co-administered: |
BAY-1238097 plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE food status: FASTED |
|
757.23 μg × h/L EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/30711772/ |
40 mg single, oral dose: 40 mg route of administration: Oral experiment type: SINGLE co-administered: |
BAY-1238097 plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE food status: FASTED |
|
904.48 μg × h/L EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/30711772/ |
80 mg single, oral dose: 80 mg route of administration: Oral experiment type: SINGLE co-administered: |
BAY-1238097 plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE food status: FASTED |
|
147.51 μg × h/L EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/30711772/ |
10 mg 1 times / week multiple, oral dose: 10 mg route of administration: Oral experiment type: MULTIPLE co-administered: |
BAY-1238097 plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE food status: FASTED |
|
819.07 μg × h/L EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/30711772/ |
40 mg 1 times / week multiple, oral dose: 40 mg route of administration: Oral experiment type: MULTIPLE co-administered: |
BAY-1238097 plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE food status: FASTED |
|
1133.08 μg × h/L EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/30711772/ |
80 mg 1 times / week multiple, oral dose: 80 mg route of administration: Oral experiment type: MULTIPLE co-administered: |
BAY-1238097 plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE food status: FASTED |
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300000042366
Created by
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1564268-08-1
Created by
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118237331
Created by
admin on Wed Apr 02 00:09:21 GMT 2025 , Edited by admin on Wed Apr 02 00:09:21 GMT 2025
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C121213
Created by
admin on Wed Apr 02 00:09:21 GMT 2025 , Edited by admin on Wed Apr 02 00:09:21 GMT 2025
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PRIMARY | NCIT | ||
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M9ALI41OQR
Created by
admin on Wed Apr 02 00:09:21 GMT 2025 , Edited by admin on Wed Apr 02 00:09:21 GMT 2025
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ACTIVE MOIETY
