PIPERACILLIN SODIUM

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C23H26N5O7S.Na
Molecular Weight	539.537
Optical Activity	UNSPECIFIED
Defined Stereocenters	4 / 4
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Na+].[H][C@]12SC(C)(C)[C@@H](N1C(=O)[C@H]2NC(=O)[C@H](NC(=O)N3CCN(CC)C(=O)C3=O)C4=CC=CC=C4)C([O-])=O

InChI

InChIKey=WCMIIGXFCMNQDS-IDYPWDAWSA-M

InChI=1S/C23H27N5O7S.Na/c1-4-26-10-11-27(19(32)18(26)31)22(35)25-13(12-8-6-5-7-9-12)16(29)24-14-17(30)28-15(21(33)34)23(2,3)36-20(14)28;/h5-9,13-15,20H,4,10-11H2,1-3H3,(H,24,29)(H,25,35)(H,33,34);/q;+1/p-1/t13-,14-,15+,20-;/m1./s1

HIDE SMILES / InChI

Description
Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2016/050684s084s086,050750s034s035lbl.pdf
Curator's Comment: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/mesh/68010878

Piperacillin is a semisynthetic, broad-spectrum, ampicillin derived ureidopenicillin antibiotic which exerts bactericidal activity by inhibiting septum formation and cell wall synthesis of susceptible bacteria. Piperacillin sodium salt is used in combination with the β-lactamase inhibitor tazobactam sodium (ZOSYN®) for the treatment of patients with moderate to severe infections caused by susceptible bacteria.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Penicillin-binding protein 1A 45 Target ID: Q8DR59 Gene ID: 934791.0 Gene Symbol: pbpA Target Organism: Streptococcus pneumoniae (strain ATCC BAA-255 / R6) Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2016/050684s084s086,050750s034s035lbl.pdf	Binding Agent 1064		940.0 nM [IC50]
Penicillin-binding protein 2B 10 Target ID: P0A3M6 Gene ID: 933948.0 Gene Symbol: penA Target Organism: Streptococcus pneumoniae (strain ATCC BAA-255 / R6) Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2016/050684s084s086,050750s034s035lbl.pdf	Binding Agent 1064		51.0 nM [IC50]

Conditions

Condition	Modality	Highest Phase	Product
Intra-abdominal infections 49 Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2016/050684s084s086,050750s034s035lbl.pdf	Curative	Approved 8429	ZOSYN Approved Use ZOSYN is a combination penicillin-class antibacterial and β-lactamase inhibitor indicated for treatment of: - Intra-abdominal infections; - Skin and skin structure infections; - Female pelvic infections; - Community-acquired pneumonia; - Nosocomial pneumonia. Launch Date 1993
Skin and skin structure infections 80 Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2016/050684s084s086,050750s034s035lbl.pdf	Curative	Approved 8429	ZOSYN Approved Use ZOSYN is a combination penicillin-class antibacterial and β-lactamase inhibitor indicated for treatment of: - Intra-abdominal infections; - Skin and skin structure infections; - Female pelvic infections; - Community-acquired pneumonia; - Nosocomial pneumonia. Launch Date 1993
Female pelvic infections 6 Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2016/050684s084s086,050750s034s035lbl.pdf	Curative	Approved 8429	ZOSYN Approved Use ZOSYN is a combination penicillin-class antibacterial and β-lactamase inhibitor indicated for treatment of: - Intra-abdominal infections; - Skin and skin structure infections; - Female pelvic infections; - Community-acquired pneumonia; - Nosocomial pneumonia. Launch Date 1993
Community-acquired pneumonia 47 Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2016/050684s084s086,050750s034s035lbl.pdf	Curative	Approved 8429	ZOSYN Approved Use ZOSYN is a combination penicillin-class antibacterial and β-lactamase inhibitor indicated for treatment of: - Intra-abdominal infections; - Skin and skin structure infections; - Female pelvic infections; - Community-acquired pneumonia; - Nosocomial pneumonia. Launch Date 1993
Nosocomial pneumonia 10 Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2016/050684s084s086,050750s034s035lbl.pdf	Curative	Approved 8429	ZOSYN Approved Use ZOSYN is a combination penicillin-class antibacterial and β-lactamase inhibitor indicated for treatment of: - Intra-abdominal infections; - Skin and skin structure infections; - Female pelvic infections; - Community-acquired pneumonia; - Nosocomial pneumonia. Launch Date 1993

C_max

Value	Dose	Co-administered	Analyte	Population
150 μg/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/23590897/	4.5 g single, intravenous dose: 4.5 g route of administration: Intravenous experiment type: SINGLE co-administered:		PIPERACILLIN plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN

AUC

Value	Dose	Co-administered	Analyte	Population
344.3 μg × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/23590897/	4.5 g single, intravenous dose: 4.5 g route of administration: Intravenous experiment type: SINGLE co-administered:		PIPERACILLIN plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN

T_1/2

Value	Dose	Co-administered	Analyte	Population
1.85 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/23590897/	4.5 g single, intravenous dose: 4.5 g route of administration: Intravenous experiment type: SINGLE co-administered:		PIPERACILLIN plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN

Doses

Dose	Population	Adverse events
2 g 4 times / day multiple, intramuscular Dose: 2 g, 4 times / day Route: intramuscular Route: multiple Dose: 2 g, 4 times / day Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/050545s053lbl.pdf	unhealthy Health Status: unhealthy Condition: serious infections caused by susceptible strains Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/050545s053lbl.pdf	Other AEs: Thrombophlebitis, Injection site pain... Other AEs: Thrombophlebitis (4%) Injection site pain (2%) Injection site erythema (2%) Injection site induration (2%) Diarrhea (2%) Loose stools (2%) Rash (1%) Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/050545s053lbl.pdf
4 g 4 times / day multiple, intravenous Dose: 4 g, 4 times / day Route: intravenous Route: multiple Dose: 4 g, 4 times / day Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/050545s053lbl.pdf	unhealthy Health Status: unhealthy Condition: serious infections caused by susceptible strains Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/050545s053lbl.pdf	Other AEs: Thrombophlebitis, Injection site pain... Other AEs: Thrombophlebitis (4%) Injection site pain (2%) Injection site erythema (2%) Injection site induration (2%) Diarrhea (2%) Loose stools (2%) Rash (1%) Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/050545s053lbl.pdf

AEs

AE	Significance	Dose	Population
Rash	1%	2 g 4 times / day multiple, intramuscular Dose: 2 g, 4 times / day Route: intramuscular Route: multiple Dose: 2 g, 4 times / day Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/050545s053lbl.pdf	unhealthy Health Status: unhealthy Condition: serious infections caused by susceptible strains Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/050545s053lbl.pdf
Diarrhea	2%	2 g 4 times / day multiple, intramuscular Dose: 2 g, 4 times / day Route: intramuscular Route: multiple Dose: 2 g, 4 times / day Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/050545s053lbl.pdf	unhealthy Health Status: unhealthy Condition: serious infections caused by susceptible strains Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/050545s053lbl.pdf
Injection site erythema	2%	2 g 4 times / day multiple, intramuscular Dose: 2 g, 4 times / day Route: intramuscular Route: multiple Dose: 2 g, 4 times / day Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/050545s053lbl.pdf	unhealthy Health Status: unhealthy Condition: serious infections caused by susceptible strains Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/050545s053lbl.pdf
Injection site induration	2%	2 g 4 times / day multiple, intramuscular Dose: 2 g, 4 times / day Route: intramuscular Route: multiple Dose: 2 g, 4 times / day Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/050545s053lbl.pdf	unhealthy Health Status: unhealthy Condition: serious infections caused by susceptible strains Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/050545s053lbl.pdf
Injection site pain	2%	2 g 4 times / day multiple, intramuscular Dose: 2 g, 4 times / day Route: intramuscular Route: multiple Dose: 2 g, 4 times / day Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/050545s053lbl.pdf	unhealthy Health Status: unhealthy Condition: serious infections caused by susceptible strains Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/050545s053lbl.pdf
Loose stools	2%	2 g 4 times / day multiple, intramuscular Dose: 2 g, 4 times / day Route: intramuscular Route: multiple Dose: 2 g, 4 times / day Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/050545s053lbl.pdf	unhealthy Health Status: unhealthy Condition: serious infections caused by susceptible strains Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/050545s053lbl.pdf
Thrombophlebitis	4%	2 g 4 times / day multiple, intramuscular Dose: 2 g, 4 times / day Route: intramuscular Route: multiple Dose: 2 g, 4 times / day Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/050545s053lbl.pdf	unhealthy Health Status: unhealthy Condition: serious infections caused by susceptible strains Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/050545s053lbl.pdf
Rash	1%	4 g 4 times / day multiple, intravenous Dose: 4 g, 4 times / day Route: intravenous Route: multiple Dose: 4 g, 4 times / day Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/050545s053lbl.pdf	unhealthy Health Status: unhealthy Condition: serious infections caused by susceptible strains Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/050545s053lbl.pdf
Diarrhea	2%	4 g 4 times / day multiple, intravenous Dose: 4 g, 4 times / day Route: intravenous Route: multiple Dose: 4 g, 4 times / day Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/050545s053lbl.pdf	unhealthy Health Status: unhealthy Condition: serious infections caused by susceptible strains Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/050545s053lbl.pdf
Injection site erythema	2%	4 g 4 times / day multiple, intravenous Dose: 4 g, 4 times / day Route: intravenous Route: multiple Dose: 4 g, 4 times / day Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/050545s053lbl.pdf	unhealthy Health Status: unhealthy Condition: serious infections caused by susceptible strains Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/050545s053lbl.pdf
Injection site induration	2%	4 g 4 times / day multiple, intravenous Dose: 4 g, 4 times / day Route: intravenous Route: multiple Dose: 4 g, 4 times / day Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/050545s053lbl.pdf	unhealthy Health Status: unhealthy Condition: serious infections caused by susceptible strains Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/050545s053lbl.pdf
Injection site pain	2%	4 g 4 times / day multiple, intravenous Dose: 4 g, 4 times / day Route: intravenous Route: multiple Dose: 4 g, 4 times / day Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/050545s053lbl.pdf	unhealthy Health Status: unhealthy Condition: serious infections caused by susceptible strains Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/050545s053lbl.pdf
Loose stools	2%	4 g 4 times / day multiple, intravenous Dose: 4 g, 4 times / day Route: intravenous Route: multiple Dose: 4 g, 4 times / day Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/050545s053lbl.pdf	unhealthy Health Status: unhealthy Condition: serious infections caused by susceptible strains Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/050545s053lbl.pdf
Thrombophlebitis	4%	4 g 4 times / day multiple, intravenous Dose: 4 g, 4 times / day Route: intravenous Route: multiple Dose: 4 g, 4 times / day Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/050545s053lbl.pdf	unhealthy Health Status: unhealthy Condition: serious infections caused by susceptible strains Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/050545s053lbl.pdf

Overview

CYP3A4	CYP2C9	CYP2D6	hERG
inhibitor 1587 inducer 781	inhibitor 1767 inducer 389

OverviewOther

Other Inhibitor	Other Substrate	Other Inducer
CYP3A5 73 CYP2C8 911 OAT1 599 OAT3 642	OAT1 326 OAT3 339	CYP3A5 76 P-gp 257

Drug as perpetrator

Target	Modality	Activity
CYP2C9 1819	inducer 1573 Sources: https://pubmed.ncbi.nlm.nih.gov/26763401/	no
CYP2C9 1819	inhibitor 3277 Sources: https://pubmed.ncbi.nlm.nih.gov/26763401/	no
CYP3A4 1925	inducer 1573 Sources: https://pubmed.ncbi.nlm.nih.gov/26763401/	no
CYP3A4 1925	inhibitor 3277 Sources: https://pubmed.ncbi.nlm.nih.gov/26763401/	no
CYP3A5 130	inducer 1573 Sources: https://pubmed.ncbi.nlm.nih.gov/26763401/	no
CYP3A5 130	inhibitor 3277 Sources: https://pubmed.ncbi.nlm.nih.gov/26763401/	no
P-gp 1650	inducer 1573 Sources: https://pubmed.ncbi.nlm.nih.gov/11850258/	no
CYP2C8 965	inhibitor 3277 Sources: https://pubmed.ncbi.nlm.nih.gov/26763401/	weak [IC50 1140 uM]
OAT1 603	inhibitor 3277 Sources: https://pubmed.ncbi.nlm.nih.gov/32104494/	yes
OAT3 644	inhibitor 3277 Sources: https://pubmed.ncbi.nlm.nih.gov/32104494/	yes

Drug as victim

Target	Modality	Activity	Metabolite	Clinical evidence
OAT3 339	substrate 3367 Sources: https://pubmed.ncbi.nlm.nih.gov/29277663/	yes [Km 172 uM]
OAT1 326	substrate 3367 Sources: https://pubmed.ncbi.nlm.nih.gov/29277663/	yes [Km 37 uM]

Sourcing

Vendor/Aggregator	ID	URL
3B Scientific (Wuhan) Corp	3B1-01410	http://www.3bsc.com/index/pro_info.php?id=21622
3B Scientific (Wuhan) Corp	3B2-1697	http://www.3bsc.com/index/pro_info.php?id=56231
AHH Chemical co.,ltd	MT-58012	http://www.ahhchemical.com/product/MT-58012.html
AHH Chemical co.,ltd	MT-58917	http://www.ahhchemical.com/product/MT-58917.html
AK Scientific, Inc. (AKSCI)	J10085	http://www.aksci.com/item_detail.php?cat=J10085
Achemtek	0102-022374	http://www.achemtek.com/61477-96-1
Angene	AGN-PC-0T0LDB	http://www.angenechemical.com/productshow/AGN-PC-0T0LDB.html
Aurora Fine Chemicals LLC	A13.110.313	http://online.aurorafinechemicals.com/info?ID=A13.110.313
Aurum Pharmatech LLC	KM0517	http://www.Aurumpharmatech.com/Product/ProductDetails/KM0517
AvaChem Scientific	4535	http://www.avachem.com/productSearch.asp?4535
BLD Pharm	BD239259	http://www.bldpharm.com/products/61477-96-1.html
BioSynth	W-105153	https://www.biosynth.com/en/products/life-science/culture-media-additives/products/W-105153.html
ChemMol	49424430	http://www.chemmol.com/chemmol/49424430.html
ChemMol	99119834	http://www.chemmol.com/chemmol/99119834.html
Chemspace	CSSB00016990198	https://chem-space.com/CSSB00016990198
Clearsynth	CS-O-14488	https://www.clearsynth.com/en/CSO14488.html
Glentham Life Sciences	GA9881	http://www.glentham.com/products/product/GA9881/
Hairui	HR134010	http://www.hairuichem.com/en/product/61477-96-1.html
LGC Standards	DRE-C16218900	https://www.lgcstandards.com/US/en/p/DRE-C16218900
LGC Standards	LGCFOR0295.00	https://www.lgcstandards.com/US/en/p/LGCFOR0295.00
LGC Standards	MM0295.00	https://www.lgcstandards.com/US/en/p/MM0295.00
Lab Network	LN00199061	https://labnetwork.com/frontend-app/p/#!/moleculedetails/LN00199061
Matrix Scientific	97252	https://www.matrixscientific.com/097252.html
MuseChem	R011373	https://www.musechem.com/product/R011373.html
OChem	6047	http://www.ocheminc.com/index.php?act=psearch&pid=477P961
Parchem	44935	https://www.parchem.com/chemical-supplier-distributor/Pipracil-044935.aspx
Smolecule	S589373	https://www.smolecule.com/products/s589373
THE BioTek	bt-505814	https://www.thebiotek.com/product/others/bt-505814
Yuhao Chemical	RT10348	http://www.chemyuhao.com/61477-96-1.html
abcr GmbH	AB479648	http://www.abcr.com/shop/en/AB479648
iChemical	EBD29493	http://www.ichemical.com/chemicals/cas-61477-96-1

PubMed

Title	Date	PubMed
Fresh vs aged benzylpenicillin on non-IgE responses in mice.	1998 Jan	10375765
Hypercoagulopathy with piperacillin administration in osteomyelitis.	2000 May	10830188
[Use of the Etest method for antimicrobial susceptibility testing of obligate anaerobes].	2001	11757426
[Achromobacter xylosoxidans bacteremia in a patient with community-acquired pneumonia].	2001	11265630
Monotherapy with meropenem versus combination therapy with piperacillin plus amikacin as empiric therapy for neutropenic fever in children with lymphoma and solid tumors.	2001 Apr-Jun	11432485
Prevalence and analysis of risk factors for infections caused by resistant Escherichia coli strains in Anhui, China.	2001 Aug	11545486
Renal abscess: recovery without hospitalization and drainage.	2001 Aug	11522095
[Interventional ERCP in patients with cholestasis. Degree of biliary bacterial colonization and antibiotic resistance].	2001 Dec	11753782
[Correlation between sensitivity to fosfomycin and the presence of penicillinase PSE-1 in Pseudomonas aeruginosa].	2001 Feb	11265218
Impaired target site penetration of beta-lactams may account for therapeutic failure in patients with septic shock.	2001 Feb	11246321
The role of topical antibiotic prophylaxis in patients undergoing contaminated head and neck surgery with flap reconstruction.	2001 Feb	11210884
Cost efficacy of tazobactam/piperacillin versus imipenem/cilastatin in the treatment of intra-abdominal infection.	2001 Jan	11252548
Possible role of cellular immunity: a case of cellulitis.	2001 Jan	11106315
A randomized prospective multicentre trial of cefpirome versus piperacillin-tazobactam in febrile neutropenia.	2001 Jul	11699402
Pulmonary infiltration with eosinophilia (PIE) syndrome induced by antibiotics, PIPC and TFLX during cancer treatment.	2001 Jul	11377237
Piperacillin with and without tazobactam against extended-spectrum beta-lactamase-producing Pseudomonas aeruginosa in a rat thigh abscess model.	2001 Jul-Aug	11399866
Ultraviolet recall-like phenomenon occurring after piperacillin, tobramycin, and ciprofloxacin therapy.	2001 Jun	11369921
Effect of beta-lactam antibiotics on the in vitro development of resistance in Pseudomonas aeruginosa.	2001 Mar	11318813
Treatment of nosocomial postoperative pneumonia in cancer patients: a prospective randomized study.	2001 Mar	11258785
Multi-drug resistant Pseudomonas aeruginosa outbreak in a burns unit--an infection control study.	2001 Mar	11226649
Seroprevalence and antibiotic sensitivity of serotypes of Salmonella enterica in Greek pig herds.	2001 Mar 31	11327648
Characterization of Pseudomonas aeruginosa isolates: occurrence rates, antimicrobial susceptibility patterns, and molecular typing in the global SENTRY Antimicrobial Surveillance Program, 1997-1999.	2001 May 15	11320454
[Comparative study of piperacillin/tazobactam versus imipenem/cilastatin in febrile neutropenia (1994-1996)].	2001 May 5	11412645
Retrospective analysis of drug-induced urticaria and angioedema: a survey of 2287 patients.	2001 Nov	11792017
Molecular epidemiology of antibiotic-resistant gram-negative bacilli in a neonatal intensive care unit during a nonoutbreak period.	2001 Nov	11694694
CAPD-associated peritonitis caused by Alcaligenes xylosoxidans sp. xylosoxidans.	2001 Nov-Dec	11799270
A multicenter, double-blind, placebo-controlled trial comparing piperacillin-tazobactam with and without amikacin as empiric therapy for febrile neutropenia.	2001 Oct 15	11565068
Piperacillin/Tazobactam versus cefotaxime plus metronidazole for treatment of children with intra-abdominal infections requiring surgery.	2001 Sep	11714046
[Survey of the antibiotic sensitivity of Pseudomonas aeruginosa in France and the distribution of beta-lactam resistance mechanisms: the GERPB 1999 study].	2001 Sep	11642015
Characterization of paired mucoid/non-mucoid Pseudomonas aeruginosa isolates from Danish cystic fibrosis patients: antibiotic resistance, beta-lactamase activity and RiboPrinting.	2001 Sep	11533004
Penetration of piperacillin/tazobactam (4 g/500 mg) into synovial tissue.	2002 Feb	11892900
Clinical evaluation of the Vitek automated system with cards GNS 122 and 127 and VTK-R07.01 software for antimicrobial susceptibility testing of Pseudomonas aeruginosa.	2002 Jan	11821175

Patents

Sample Use Guides

In Vivo Use Guide

The usual total daily dose of ZOSYN® for adults is 3.375 g every six hours totaling 13.5 g (12.0 g piperacillin/1.5 g tazobactam). The usual duration of ZOSYN® treatment is from 7 to 10 days. ZOSYN® should be administered by intravenous infusion over 30 minutes.

Route of Administration: Intravenous

In Vitro Use Guide

The MIC values for piperacillin/tazobactam were: 1-4 ug/ml (Escherichia coli ATCC 25922), 0.5-2 ug/ml (Escherichia coli ATCC 35218), 1-8 ug/ml (Pseudomonas aeruginosa ATCC 27853), 0.06-0.5 ug/ml (Haemophilus influenzae ATCC 49247), 0.25-2 ug/ml (Staphylococcus aureus ATCC 29213), 0.12-0.5 ug/ml (Bacteroides fragilis ATCC 25285), 4-16 ug/ml (Bacteroides thetaiotaomicron ATCC 29741).

Name

Type

Language

PIPERACILLIN SODIUM

Official Name

English

Piperacillin sodium [WHO-DD]

Common Name

English

T-1220

Code

English

Sodium (2S,5R,6R)-6-[(R)-2-(4-ethyl-2,3-dioxo-1-piperazinecarboxamido)-2-phenylacetamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate

Common Name

English

PIPERACILLIN SODIUM [JAN]

Common Name

English

PIPERACILLIN SODIUM [EP MONOGRAPH]

Common Name

English

CL-227193

Code

English

ZOSYN COMPONENT PIPERACILLIN SODIUM

Common Name

English

PENMALIN

Brand Name

English

PIPRACIL

Brand Name

English

PIPERACILLIN SODIUM [USP MONOGRAPH]

Common Name

English

PIPERACILLIN SODIUM [USAN]

Common Name

English

PIPERACILLIN SODIUM COMPONENT OF ZOSYN

Common Name

English

4-THIA-1-AZABICYCLO(3.2.0)HEPTANE-2-CARBOXYLIC ACID, 6-(((((4-ETHYL-2,3-DIOXO-1-PIPERAZINYL)CARBONYL)AMINO)PHENYLACETYL)AMINO)-3,3-DIMETHYL-7-OXO-, MONOSODIUM SALT, (2S-(2.ALPHA.,5.ALPHA.,6.BETA.(S*)))

Systematic Name

English

PIPERACILLIN SODIUM SALT [MI]

Common Name

English

NSC-757277

Code

English

PIPERACILLIN SODIUM [VANDF]

Common Name

English

PIPERACILLIN SODIUM SALT

Common Name

English

PIPERACILLIN (AS SODIUM)

Common Name

English

CL 227,193

Code

English

PIPERACILLIN SODIUM [ORANGE BOOK]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C1558